The relative value of CD4 cell count and quantitative HIV-1 RNA in predicting survival in HIV-1-infected women: results of the women‚s interagency HIV study

Anastos, Kathryn; Kalish, Leslie A.; Hessol, Nancy A.; Weiser, Barbara; Melnick, Sandra; Burns, David; Delapenha, Robert; DeHovitz, Jack; Cohen, Mardge H.; Meyer, William A.; Bremer, James W.; Kovács, Andrea

doi:10.1097/00002030-199909100-00016

Cited by 58 publications

(45 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ϩ T cell counts, as both of these were shown in numerous studies to be markers of HIV-1 disease progression (2,15,21,37,38,44,46). Consistent with the earlier studies, the absolute CD4 ϩ T-cell count correlated inversely with vRNA in the current cohort (r ϭ Ϫ0.62, P ϭ 0.005).…”

Section: Detection Of Hiv-1-specific Ifn-␥-secreting Cellssupporting

confidence: 89%

See 1 more Smart Citation

Magnitude of Functional CD8⁺T-Cell Responses to the Gag Protein of Human Immunodeficiency Virus Type 1 Correlates Inversely with Viral Load in Plasma

Edwards¹,

Bansal²,

Sabbaj³

et al. 2002

J Virol

322

238

View full text Add to dashboard Cite

The importance of CD8؉ T-cell responses in the control of human immunodeficiency virus type 1 (HIV-1) infection has been demonstrated, yet few studies have been able to correlate these responses with markers of HIV-1 disease progression. This study measured cell-mediated immune responses using peripheral blood mononuclear cells (PBMC) obtained from 27 patients with chronic HIV-1 infection, the majority of whom were off antiretroviral therapy. The ELISPOT assay was used to detect gamma interferon-secreting PBMC after stimulation with overlapping HIV-1 peptides spanning the Gag, Pol, Env, and Nef proteins in addition to the baculovirus-derived p24 and gp160 proteins. All volunteers had responses to at least one HIV-1-specific peptide. All but one of the subjects (96%) responded to the Gag peptide pool, and 86% responded to the Pol and/or Nef peptide pools. The magnitude and the breadth of T-cell responses directed to either the Gag or p24 peptide pools correlated inversely with viral load in plasma (r ‫؍‬ ؊0.60, P < 0.001 and r ‫؍‬ ؊0.52, P < 0.005, respectively) and directly with absolute CD4 ؉ T-cell counts (r ‫؍‬ 0.54, P < 0.01 and r ‫؍‬ 0.39, P < 0.05, respectively) using the Spearman rank correlation test. Responses to the Pol and integrase peptide pools also correlated with absolute CD4 ؉ T-cell counts (r ‫؍‬ 0.45, P < 0.05 and r ‫؍‬ 0.49, P < 0.01, respectively). No correlation with markers of disease progression was seen with specific T-cell responses directed toward the Env or Nef peptides. These data serve as strong evidence that major histocompatibility complex class I presentation of Gag peptides is an essential feature for any HIV-1 vaccine designed to elicit optimal CD8 ؉ T-cell responses.

show abstract

Section: Detection Of Hiv-1-specific Ifn-␥-secreting Cellssupporting

confidence: 89%

“…ϩ T-cell counts with HIV-1 disease progression (2,15,21,37,38,44,46), these immune responses to Gag (as detected by the ELISPOT assay) would likely correlate with progression to AIDS as well.…”

Section: Discussionmentioning

confidence: 99%

Magnitude of Functional CD8⁺T-Cell Responses to the Gag Protein of Human Immunodeficiency Virus Type 1 Correlates Inversely with Viral Load in Plasma

Edwards¹,

Bansal²,

Sabbaj³

et al. 2002

J Virol

322

238

View full text Add to dashboard Cite

show abstract

“…4 Fourth, the CD4+ lymphocyte count is critical in predicting the risk of opportunistic infections and is a better predictor of mortality than is the viral load. 28,29 Finally, the survival advantage associated with highly active antiretroviral therapy is compromised only if such therapy is withheld until the CD4+ lymphocyte count is less than 200 per cubic millimeter. 29,30 Although we did not determine the optimal time for initiating therapy, these factors suggest that the cutoff values in the current guidelines should be reassessed in the light of the equal risk of disease progression for men and women and their equal eligibility for therapy if the CD4+ lymphocyte count is the criterion.…”

Section: Discussionmentioning

confidence: 99%

Initial Plasma HIV-1 RNA Levels and Progression to AIDS in Women and Men

et al. 2001

View full text Add to dashboard Cite

show abstract

“…Containment of viral load is considered a critical parameter in the assessment of vaccine efficacy [47][48][49][50], since high levels of viral load early after infection can be predictive of disease progression [43,[51][52][53][54][55][56][57][58]. Indeed, in the vaccinated and protected monkeys from this study, viral load (either cell-or plasma-associated) was persistently low or undetectable and CD4 T-cell decline did not occur.…”

Section: Discussionmentioning

confidence: 99%

Long-term protection against SHIV89.6P replication in HIV-1 Tat vaccinated cynomolgus monkeys

Maggiorella

Baroncelli

Michelini

et al. 2004

Vaccine

View full text Add to dashboard Cite

Vaccination with a biologically active Tat protein or tat DNA contained infection with the highly pathogenic SHIV89.6P virus, preventing CD4 T-cell decline and disease onset. Here we show that protection was prolonged, since neither CD4 T-cell decline nor active virus replication was observed in all vaccinated animals that controlled virus replication up to week 104 after the challenge. In contrast, virus persisted and replicated in peripheral blood mononuclear cells and lymph nodes of infected animals, two of which died. Tat-specific antibody, CD4 and CD8 T-cell responses were high and stable only in the animals controlling the infection. In contrast, Gag-specific antibody production and CD4 and CD8 T-cell responses were consistently and persistently positive only in the monkeys that did not control primary virus replication. These results indicate that vaccination with Tat protein or DNA induced long-term memory Tat-specific immune responses and controlled primary infection at its early stages allowing a long-term containment of virus replication and spread in blood and tissues.

show abstract

The relative value of CD4 cell count and quantitative HIV-1 RNA in predicting survival in HIV-1-infected women: results of the women‚s interagency HIV study

Abstract: CD4 cell count and HIV-1 RNA had similar prognostic value in this cohort of HIV-1-infected women. Even in the presence of a low viral burden, a substantially decreased CD4 cell count remained a strong predictor of mortality.

Cited by 58 publications

References 22 publications

Magnitude of Functional CD8⁺T-Cell Responses to the Gag Protein of Human Immunodeficiency Virus Type 1 Correlates Inversely with Viral Load in Plasma

Magnitude of Functional CD8⁺T-Cell Responses to the Gag Protein of Human Immunodeficiency Virus Type 1 Correlates Inversely with Viral Load in Plasma

Initial Plasma HIV-1 RNA Levels and Progression to AIDS in Women and Men

Long-term protection against SHIV89.6P replication in HIV-1 Tat vaccinated cynomolgus monkeys

Contact Info

Product

Resources

About

The relative value of CD4 cell count and quantitative HIV-1 RNA in predicting survival in HIV-1-infected women: results of the women‚s interagency HIV study

Abstract: CD4 cell count and HIV-1 RNA had similar prognostic value in this cohort of HIV-1-infected women. Even in the presence of a low viral burden, a substantially decreased CD4 cell count remained a strong predictor of mortality.

Cited by 58 publications

References 22 publications

Magnitude of Functional CD8+T-Cell Responses to the Gag Protein of Human Immunodeficiency Virus Type 1 Correlates Inversely with Viral Load in Plasma

Magnitude of Functional CD8+T-Cell Responses to the Gag Protein of Human Immunodeficiency Virus Type 1 Correlates Inversely with Viral Load in Plasma

Initial Plasma HIV-1 RNA Levels and Progression to AIDS in Women and Men

Long-term protection against SHIV89.6P replication in HIV-1 Tat vaccinated cynomolgus monkeys

Contact Info

Product

Resources

About

Magnitude of Functional CD8⁺T-Cell Responses to the Gag Protein of Human Immunodeficiency Virus Type 1 Correlates Inversely with Viral Load in Plasma

Magnitude of Functional CD8⁺T-Cell Responses to the Gag Protein of Human Immunodeficiency Virus Type 1 Correlates Inversely with Viral Load in Plasma