The relaxant property of local prostaglandin E2 on the non-pregnant uterus — A cyclic triphasic response

Toppozada, M.; Gaafar, Alaa; Shaala, S.; Osman, Mohamed

doi:10.1016/0090-6980(75)90154-9

Cited by 19 publications

(2 citation statements)

References 9 publications

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“…also generally agreed that in most cases PGE2 has a stimulatory effect during the early proliferative and late secretory phases of the menstrual cycle. While we observed that the uterus was insensitive to prostaglandin around ovulation time, Toppozada et al (17,18) found an inhibitory effect of PGE2 if high doses ( 1 00-300 pg) were given by the intrauterine route. A change from stimulation to inhibition of uterine contractility in vivo has earlier been reported by Eliasson and Posse (4) following vaginal administration of a crude prostaglandin preparation, not, however, by increasing the dose, but by increasing the sensitivity of the myometrium by the addition of an intravenous infusion of a mixture of vasopressin and oxytocin.…”

Section: Discussionmentioning

confidence: 44%

Effects of the Prostaglandins on the Uterus

Bygdeman

Bremme

Gillespie

et al. 1979

Acta Obstet Gynecol Scand

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The effect of intravenous and intrauterine administration of PGEl or PGE2 and P G F Z~ as well as oral administration of PGE2 on the sensitivity and reactivity of the nonpregnant human uterus was studied. With the use of the flaccid microballoon technique or a micro transducer catheter, uterine recordings were made at frequent intervals throughout the menstrual cycle. Independently of the route of administration and of the phase of the cycle, treatment with P G F z~ invariably resulted in stimulation of uterine motility. A high sensitivity t o PGFza was noted during the late secretory phase both in normal and dysmenorrheic women.A marked decrease in sensitivity to both PGE2 and PGF2u administered by the intrauterine route was observed in the periovulatory phase. Inhibition of uterine contractility by PGE2 following both intrauterine and oral administration was noted during active menstrual bleeding in normal as well as in dysmenorrheic women.These findings suggest that endogenous prostaglandins may play a role in the regulation of the normal uterine motility during the menstrual cycle and that the main reason for the abnormal contractility pattern seen in dysmenorrheic women during menstrual bleeding is an increased PGF2,/PGE2 ratio.

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Section: Discussionmentioning

confidence: 44%

Effects of the Prostaglandins on the Uterus

Bygdeman

Bremme

Gillespie

et al. 1979

Acta Obstet Gynecol Scand

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“…Certain prostaglandins are uterotonic, with some being used for labor induction and first or second trimester abortions. When administered to non-pregnant, menstruating women, PGE2 stimulates uterine contractions, this effect being more pronounced during the proliferative than in the secretory phase of the menstrual cycle (1,2,3).…”

mentioning

confidence: 99%

Lack of Effect of Arbaprostil on the Human Non‐pregnant Uterus

Reele

Euler

Hanover

et al. 1985

Acta Obstet Gynecol Scand

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Arbaprostil ((15R)-15-methyl Prostaglandin E2) is being studied for the treatment of gastrointestinal illness. To determine its effect on the human uterus, eight sterilized pre-menopausal women were studied during the proliferative phase of their menstrual cycle. Using a microtransducer catheter, intra-uterine pressures were recorded for at least 30 minutes prior to and 2 hours after arbaprostil administration. Each subject was studied four times, at 48-hour intervals, receiving in a double-blind manner; 0, 10, 25, and 50 micrograms. Arbaprostil at does up to 50 micrograms was found not to have any clinically significant effects on the non-pregnant human uterus.

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