The Relaxing Effect of Bradykinin on Intestinal Smooth Muscle

Antonio, A.

doi:10.1111/j.1476-5381.1968.tb00431.x

Cited by 36 publications

(33 citation statements)

References 6 publications

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“…This finding confirms the results obtained by ANTONIO (11). Seeing that rutin -induced rat duodenum relaxations were not inhibited by propranolol, it might be thought that the relaxant effect of rutin on smooth muscle does not occur as a result of catecholamine relaease or catecholamme-like action.…”

Section: And Discussionsupporting

confidence: 81%

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Effect of Rutin on the Isolated Rat Duodenum and Comparison with the Effects of Adrenaline, Isoprenaline and Papaverine

Altinkurt¹,

Öztürk²

2008

Ankara Universitesi Eczacilik Fakultesi Dergisi

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SUMMARYThe experiments were performed by using isolated rat duodenum. Rutin, a natural flavonoid compound, caused relaxations of the rat duodenum dose-dependently. The relaxant effect of rutin on the rat duodenum was examined in comparison with that of adrenaline, isoprenaline and papaverine. In addition, propranolol, a beta-adrenergic blocking agent, phentolamine, an alpha-adrenergic blockingagent and nicotinic acid, an adenyl cyclase inhibitor were used as tools to investigate mechanism of the relaxant effect of rutin on the rat duodenum in vitro. ÖZETDeneyler izole sıçan duodenumu kullanılarak sürdürüldü. Doğal bir flavonoid bileşiği olan rutin doza bağımlı biçimde sıçan duodenumunu gevşetti. Rutin'in sıçan duodenumundaki gevşetici etkisi adrenalin, izoprenalin ve papaverin ile karşılaştırmalı olarak incelendi. Ayrıca, rutin'in sıçan duodenumundaki gevşetici etkisinin mekanizmasını araştırmak için beta-adrenerjik bloker olan propranolol, alfaadrenerjik bloker olan fentolamin ve bir adenil siklaz inhibitörü olan nikotinik asid de kullanıldı.

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Section: And Discussionsupporting

confidence: 81%

“…Catecholamines may cause relaxations of some smooth muscles (8)(9)(10)(11)(12)(13)(14), some vascular smooth muscles (8,(15)(16)(17), uterus (8,(18)(19)(20)(21)(22)(23). The action of catecholamines son these muscles is mainly due to beta-adrenoceptor activation and able to be blocked by beta-adrenergic blocking agents (12-14, 17, 19).…”

Section: And Discussionmentioning

confidence: 99%

Effect of Rutin on the Isolated Rat Duodenum and Comparison with the Effects of Adrenaline, Isoprenaline and Papaverine

Altinkurt¹,

Öztürk²

2008

Ankara Universitesi Eczacilik Fakultesi Dergisi

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“…Although the physiological function of Ca2+/Mg2+-ATPase is not well understood, it is generally accepted that this enzyme is involved in Ca2' binding to the membrane (Moore et al, 1975). The deficiency in Ca2+ handling can be compared to the condition described by Antonio (1968), in which the isolated duodenum equilibrated in low calcium medium presented similar contractile responses. In both conditions the Na' conductance is increased (Brading et al, 1969;Postnov et al, 1979), which favours the contractile component of the response induced by bradykinin (Boschcov et al, 1984).…”

Section: Discussionmentioning

confidence: 99%

“…A few studies of this kind have been done using the genetically hypertensive rat and the stomach fundus and vas deferens were found to exhibit alterations similar to those previously described for vascular smooth muscle (Altman et al, 1977;Caulfield et al, 1977;Yanagawa et al, 1978;Corbett et al, 1980;Kwan et al, 1982). To gain further information on this problem we have made use of the interesting properties of the rat duodenum, which gives a biphasic response to some stimulants: low concentrations of K+ or bradykinin induce relaxation whereas higher concentrations of these agents also cause contraction (Antonio, 1968;Faber & van der Meer, 1973;Boschcov et al, 1984). In the case of bradykinin, the biphasic response appears to be due to two different receptors, and to be determined by the Na' permeability across the membrane (Boschcov et al, 1984).…”

Section: Introductionmentioning

confidence: 99%

Reactivity to bradykinin and potassium of the isolated duodenum from rats with genetic and renal hypertension

Miasiro

Paiva

Pereira

et al. 1985

British J Pharmacology

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1 The biphasic (relaxation-contraction) response of the isolated duodenum was used to study the reactivity of non-vascular smooth muscles in genetic (SHR) and renal hypertensive rats compared to their respective controls (WKY and Wistar). 2 For the contractile component of the response to bradykinin, the duodenum from WKY rats was more sensitive, whereas the duodenum from SHR was both more sensitive and hyperreactive, compared to that from Wistar rats. 3 The relaxant component of the response to bradykinin was present in the duodenum of both WKY rats and SHR, but was concentration-dependent only in the WKY group. 4 The relaxant response to K+ was very small in SHR, and was not concentration-dependent. 5 The concentration-response curves for relaxant responses to adrenaline and for contractile responses to acetylcholine did not differ in the SHR and WKY groups. 6 Ca2+/Mg2+-ATPase activity was found to be markedly reduced in the SHR group. 7 No qualitative or quantitative differences were observed between the responses of the duodenum of renal hypertensive rats and those of their normotensive controls. 8 It is proposed that the altered reactivity of the SHR duodenum is due to changes in ion handling by the smooth muscle cell membrane.

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“…From evidence obtained in uterine tissue (10), it has been pointed out that ACh owes its spasmogenic effects on certain smooth muscle at least in part to a depolarizing action accompanied by an influx of extracellular calcium into the contractile cell. Furthermore, many authors suggest that barium produces its spasmogenic effects primarily by releasing bound calcium from intracellular storage pools (11)(12)(13)(14)(15). In addition, Van Breemen et al suggested that NE initiates aortic contractions by releasing intracellularly sequestered calcium (16).…”

mentioning

confidence: 99%