1969
DOI: 10.1111/j.1476-5381.1969.tb07982.x
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The release and fate of vaso‐active hormones in the circulation

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Cited by 641 publications
(258 citation statements)
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References 141 publications
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“…Thus, the pressor potency was reduced by treatment with the catecholamine depleting substances, reserpine and syrosingopine, and was restored by infusions of catecholamines. Similarly, inhibition of monoamine oxidase which has been shown to increase peripheral levels of catecholamines (Goldberg & Shideman, 1962;Sanan & Vogt, 1962) (Feldberg & Lewis, 1964, 1965Vane, 1969 (Bickerton & Buckley, 1961) and via central vagal inhibition (Scroop & Lowe, 1968). The failure of both pempidine and bethanidine to reduce the angiotensin pressor responses in the present experiments argues against a significant central component to the response.…”
contrasting
confidence: 38%
“…Thus, the pressor potency was reduced by treatment with the catecholamine depleting substances, reserpine and syrosingopine, and was restored by infusions of catecholamines. Similarly, inhibition of monoamine oxidase which has been shown to increase peripheral levels of catecholamines (Goldberg & Shideman, 1962;Sanan & Vogt, 1962) (Feldberg & Lewis, 1964, 1965Vane, 1969 (Bickerton & Buckley, 1961) and via central vagal inhibition (Scroop & Lowe, 1968). The failure of both pempidine and bethanidine to reduce the angiotensin pressor responses in the present experiments argues against a significant central component to the response.…”
contrasting
confidence: 38%
“…This inhibitor specificity may explain the conflict between the results of Udenfriend, Weissbach & Bogdansky (1957), who could not affect 5-HT metabolism in the whole mouse with iproniazid, and those of Axelrod & Inscoe (1963) and of Gershon & Ross (1966a) who demonstrated an inhibition of 5-HT metabolism in the mouse using another MAO inhibitor, JB 516. These last authors have also shown that the radioactivity in mouse lung derived either from "4C-5-HTP (Gershon & Ross, 1966b) or from '4C-5-HT (personal communication to J. R. Vane quoted in Vane, 1969) is mainly in septal cells which could be either alveolar macrophages (as they suggest) or Type II alveolar cells (Heinemann & Fishman, 1969). Either these septal cells or the endothelial cells lining the lung capillaries (Hughes et al, 1969) would be readily accessible to amines in the capillaries, but neither contain granules of the type generally associated with binding of biogenic amines.…”
Section: Discussionmentioning
confidence: 99%
“…The lung has been shown to play an important part in the metabolism of several vaso-active hormones (Vane, 1969). 5-Hydroxytryptamine (5-HT) is removed from the circulation by the lungs of the anaesthetized dog (Davies & Wang, 1965;Thomas & Vane, 1967), and isolated cat's lung perfused with blood also removed 5-HT (Gaddum, Hebb, Silver & Swan, 1953).…”
Section: Introductionmentioning
confidence: 99%
“…The blood-bathed organ technique (Vane, 1964(Vane, , 1969 was used to measure release of prostaglandin-like material from dog spleen in vivo. Seventeen dogs of either sex weighing 11 5-24 kg were anaesthetized with pentobarbitone sodium (30 mg/kg intravenously).…”
Section: Blood-bathed Organ Experimentsmentioning
confidence: 99%