The release of soluble adhesion molecules ICAM-1 and E-selectin after acute myocardial infarction and following coronary angioplasty

Siminiak, Tomasz; Dye, Julian F.; Egdell, Robin; More, Ranjit; Wysocki, Henryk; Sheridan, Desmond J.

doi:10.1016/s0167-5273(97)00161-7

Cited by 29 publications

(21 citation statements)

References 20 publications

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“…This possibility is supported by data obtained for sICAM-1 results at days three and seven. The rise of sICAM-1 has already been found to be associated with AMI (Siminiak et al 1997) also as a consequence of injury during m y o c a r d i a l i s c h e m i a a n d r e p e r f u s i o n (Frangogiannis et al 2002). The raise of sICAM-1 levels was described in patients with unstable angina pectoris, but not in patients with stable angina (Kaikita et al 1997;Ogawa et al 1999).…”

Section: Discussionmentioning

confidence: 92%

Persistent Oxidative Stress after Myocardial Infarction Treated by Percutaneous Coronary Intervention

Nikolić-Heitzler

Rabuzin

Tatzber

et al. 2006

Tohoku J. Exp. Med.

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[247][248][249][250][251][252][253][254][255] Acute myocardial infarction causing cardiac ischemia is responsible for the majority of cardiac related deaths. Medical interventions that ensure rapid reperfusion, such as percutaneous coronary intervention, are aimed to allow myocardial re-oxygenation. However, this generates reactive oxygen species, resembling ischemiareperfusion type of injury based on oxidative stress. In the present study we monitored dynamic changes of total serum peroxides, total antioxidant capacity and soluble intercellular adhesion molecule-1 as well as the titer of antibodies against oxidized low-density lipoproteins in the blood during the convalescence period of 32 patients with acute myocardial infarction treated by percutaneous coronary intervention. Samples were taken at admittance and at two hours, four hours, three days and seven days following percutaneous coronary intervention. Total antioxidant capacity dropped to 82% ( p < 0.05). The titer of antibodies against oxidized low-density lipoproteins transiently decreased within the first three days, and increased afterwards. The values of serum peroxides and soluble intercellular adhesion molecule-1 increased continuously in respect to the initial levels reaching the maximum at the time of release from hospital. These findings indicate a persistent oxidative stress that might be associated with intravascular inflammation in patients during convalescence and release from hospital. myocardial infarction; percutaneous coronary intervention; inflammation; soluble intercellular adhesion molecule-1; lipid peroxidation © 2006 Tohoku University Medical Press While oxidative stress has been shown to be related with the age and living habits (Ozbay and Dulker 2002), it plays an important role in the development of vascular diseases that affect vital organs, in particular brain and heart (Zarkovic 2003;Zarkovic et al. 2004;Madamanchi et al.

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Section: Discussionmentioning

confidence: 92%

Persistent Oxidative Stress after Myocardial Infarction Treated by Percutaneous Coronary Intervention

Nikolić-Heitzler

Rabuzin

Tatzber

et al. 2006

Tohoku J. Exp. Med.

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“…14 In the present study, we have measured the plasma concentrations of the soluble adhesion molecules P-selectin (sPselectin) and intercellular adhesion molecule-1 (sICAM-1) in patients undergoing angioplasty for established coronary artery disease.…”

Section: ±17mentioning

confidence: 99%

Effect of vitamin E supplementation on circulating cell adhesion molecules pre- and post-coronary angioplasty

Ferns¹,

Forster²,

Williams³

et al. 2000

Ann Clin Biochem

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SUMMARY.The soluble adhesion molecules P-selectin (sP-selectin) and intercellular adhesion molecule-1 (sICAM-1) are derived from platelets and endothelial cells. Circulating concentrations of these soluble adhesion molecules are raised in patients with atherosclerosis and following percutaneous transluminal coronary angioplasty (PTCA). We have investigated the effects of vitamin E supplements (800 IU/day) on circulating plasma ICAM-1 and P-selectin levels pre-and post-PTCA. Patients, randomized to group, were pre-treated with vitamin E or placebo (soybean oil) for 1 month before routine PTCA. Plasma sICAM-1 and sP-selectin were measured by enzyme-linked immunosorbent assay on blood taken immediately pre-and post-PTCA. Total protein and a-tocopherol were measured on the same samples. Plasma a-tocopherol concentrations increased in patients receiving vitamin E: 19´1 (1´5) [mean (standard error of the mean, SEM)] mg/mL post-PTCA versus 13´9 (0´6) mg/ mL pre-PTCA (n=23; P50´01). Plasma sP-selectin and sICAM-1 levels were not signi®cantly increased following PTCA in the vitamin E group. Pre-angioplasty mean (SEM) plasma sP-selectin concentration in the vitamin E group was 8´83 (0´97) ng/mg protein; the corresponding mean post-angioplasty value was 9´34 (0´89) ng/mg protein (P=0´85). The mean (SEM) pre-angioplasty sICAM-1 concentration in this group was 2´18 (0´24) ng/mg protein, and was 2´20 (0´23) ng/ mg protein following angioplasty (P=0´84). In the placebo group (n=24) there was a signi®cant increase in mean (SEM) sP-selectin concentration following angioplasty, from 7´48 (0´73) to 9´70 (0´78) ng/mg protein (P50´05). The change (mean, SEM) in plasma sP-selectin concentration following angioplasty was signi®cantly greater for the placebo group [2´22 (0´50) ng/mg protein] than for the group receiving vitamin E [0´50 (0´50) ng/mg protein] (P50´02). This difference remained signi®cant (P50´05) even after adjustment for pre-angioplasty P-selectin concentrations. Mean (SEM) plasma sICAM-1 concentrations remained unchanged following angioplasty [preangioplasty: 2´16 (0´20) ng/mg protein; post-angioplasty: 1´97 (0´13) ng/mg protein]. Vitamin E may therefore limit platelet or endothelial activation during PTCA.Vitamin E is a potent, lipid-soluble plasma antioxidant. Taking supplements of vitamin E has been shown to be associated with reduced risk of coronary heart disease in men and women.

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“…Increased levels of sICAM-1 in the coronary sinus samples immediately after coronary angioplasty have also been shown by other investigators. 32 Recent studies have demonstrated expression of ICAM-1 on human atherosclerotic plaque. 33 Circulating sICAM-1 appears to be slowly released from activated vascular endothelial cells.…”

Section: Mac-1 Is An Indicator Of Vascular Injury and Inflammation Afmentioning

confidence: 99%

Lower Expression of Neutrophil Adhesion Molecule Indicates Less Vessel Wall Injury and Might Explain Lower Restenosis Rate After Cutting Balloon Angioplasty

et al. 1998

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Background-The Cutting Balloon is a novel dilatation catheter for coronary angioplasty (InterVentional Technologies Inc). It produces longitudinal, microsurgical incisions in the vessel wall before the actual dilatation. It is assumed that these controlled surgical incisions relieve hoop stress and reduce vessel wall injury and eventually restenosis. However, no clinical indicator to support the theory of reduced injury has been described. Certain clusters of differentiation (eg, CD11, CD18 on the leukocytes) are implicated in leukocyte adhesion, increased permeability, and opsonization. Therefore, they might serve as clinical indicators of the injury level of the vessels after angioplasty. Methods and Results-We randomly selected 64 patients with isolated left anterior descending coronary artery disease for either Cutting Balloon angioplasty or conventional balloon angioplasty. The expression of CD18 and CD11b on the surface of neutrophils was determined by flow cytometric analysis. Serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) were also measured. The expression of both the CD18 and CD11b in the coronary sinus blood gradually increased and reached its maximum at 48 hours after angioplasty. The sICAM-1 levels in the coronary sinus serum also increased after angioplasty. Percentage increases of CD18 and CD11b expression and the increase of the sICAM-1 levels at 48 hours after angioplasty (as ratios to baseline values before angioplasty) were less in the Cutting Balloon angioplasty group than in the conventional balloon angioplasty group (CD18, 1.10Ϯ0.05 versus 1.31Ϯ0.05, PϽ0.05; CD11b, 1.23Ϯ0.06 versus 1.72Ϯ0.10, PϽ0.001; sICAM-1, 1.12Ϯ0.05 versus 1.25Ϯ0.02, PϽ0.05). In all patients, the late lumen loss at follow-up angiogram positively correlated with the increased levels of CD11b (Rϭ0.59, PϽ0.001) and sICAM-1 (Rϭ0.38, PϽ0.05) at 48 hours after angioplasty. Conclusions-Balloon angioplasty upregulated Mac-1 (CD11b/CD18) on the surface of the neutrophils and increased sICAM-1 levels in association with late loss increase. These changes were significantly smaller in the Cutting Balloon angioplasty group than in the conventional balloon angioplasty group. This suggests that Cutting Balloon angioplasty may produce less vessel wall injury and, consequently, less neutrophil activation, which may account for the lower rate of restenosis.

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The release of soluble adhesion molecules ICAM-1 and E-selectin after acute myocardial infarction and following coronary angioplasty

Cited by 29 publications

References 20 publications

Persistent Oxidative Stress after Myocardial Infarction Treated by Percutaneous Coronary Intervention

Persistent Oxidative Stress after Myocardial Infarction Treated by Percutaneous Coronary Intervention

Effect of vitamin E supplementation on circulating cell adhesion molecules pre- and post-coronary angioplasty

Lower Expression of Neutrophil Adhesion Molecule Indicates Less Vessel Wall Injury and Might Explain Lower Restenosis Rate After Cutting Balloon Angioplasty

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