The release of spasmogenic substances from human chopped lung tissue and its inhibition

Piper, Priscilla J.; Walker, Joyce L.

doi:10.1111/j.1476-5381.1973.tb08327.x

Cited by 107 publications

(28 citation statements)

References 18 publications

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“…Prostaglandins can be readily demonstrated in human lungs and lungs of laboratory animals and released in physiologically significant quantities from passively sensitized human lung fractions during challenge with antigens (Piper & Walker, 1973). All these data taken together indicate that the endogenous prostaglandin E series mediate feed-back inhibitory mechanisms for acetylcholine release by nerve stimulation, that the prolonged treatment with idomethacin induces spontaneous electrical and mechanical activities of the trachea, and that the alterations in properties of the nerve terminals result in release of the transmitter.…”

Section: Discussionmentioning

confidence: 80%

Spontaneous Activity in the Trachea of Dogs Treated With Indomethacin: An Experimental Model for Aspirin‐related Asthma

Ito

Tajima

1981

British J Pharmacology

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1 Electrical and mechanical properties of smooth muscle cells or of neuro-effector transmission in the smooth muscle layer of the dog trachea, were studied after treatment with indomethacin, by means of the double sucrose gap, microelectrode or tension recording methods. 2 After several subcutaneous injections of indomethacin (1.0 mg/kg daily), 6 out of 12 dogs were coughing and wheezing. 3 Smooth muscle tissues dissected from the trachea of the coughing dog showed spontaneous electrical and mechanical activities at the frequency of 8-15 per min. These spontaneous electrical and mechanical activities were completely suppressed by treatment with atropine (10-6 M), isoprenaline (5 x 10-7 M) or prostaglandin E2 (10-9 M) but not by tetrodotoxin (1.5 x 10-6 M). 4 Direct muscle stimulation induced oscillatory potential changes followed by tension development in the trachea of the indomethacin-treated dog. 5 In the indomethacin-treated dog, mean membrane potential of the tracheal smooth muscle cells was -52.4 mV, and in the control trachea, the potential was -59.0 mV. 6 In the trachea from control dogs, the amplitude of test e.j.ps after conditioning e.j.ps was always smaller than the conditioning e.j.p., at any time interval between the two stimuli. In the trachea from indomethacin-treated dogs, facilitation phenomena were observed. 7 In the trachea from the indomethacin-treated dog, prostaglandin E, (PGE,) or PGE2 (10-")'-10-9 M) markedly suppressed the amplitude of the e.j.p. but did not affect the facilitation phenomenon. 8 These results indicate that endogenous prostaglandins play important physiological roles in the feed-back inhibitory mechanisms for acetylcholine release from the nerve terminals during the resting and active states. 9 The results are also discussed in relation to the genesis of aspirin-induced asthma in man.

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Section: Discussionmentioning

confidence: 80%

Spontaneous Activity in the Trachea of Dogs Treated With Indomethacin: An Experimental Model for Aspirin‐related Asthma

Ito

Tajima

1981

British J Pharmacology

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“…The prostaglandin synthesis accompanying lung anaphylaxis has been considered a secondary event (2,29 (33,34).…”

Section: Discussionmentioning

confidence: 99%

The Effects of the Immunologic Release of Histamine upon Human Lung Cyclic Nucleotide Levels and Prostaglandin Generation

Platshon¹,

Kaliner²

1978

J. Clin. Invest.

128

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“…The most useful tissue for 5-HT assay was the rabbit aorta. After it had been verified that no rabbit aorta contracting substance (RCS) was released from sensitized rat lungs by antigen challenge, as found by Piper & Walker (1973) in actively sensitized rats, the rabbit aorta was used regularly for the detection of 5-HT. Higher sensitivity was found in spirally cut strips taken from young female rabbits.…”

Section: Passive Lung Anaphylaxis In Vitromentioning

confidence: 99%

Mediators of Passive Lung Anaphylaxis in the Rat

Farmer¹,

Richards²,

Sheard³

et al. 1975

British J Pharmacology

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1 Passive lung anaphylaxis (PLA) was investigated in rats sensitized by the intravenous injection of high titre reaginic antiserum prepared in rats. 2 The effect of various pharmacological antagonists on anaphylactic bronchoconstriction in vivo were examined. An antihistamine (mepyramine), a kallikrein inactivator (aprotinin) or a prostaglandin synthesis inhibitor (aspirin) did not inhibit PLA, whereas an anti-5-hydroxytryptamine agent (methysergide) and an anti-slow reacting substance-A agent (FPL, 55712) significantly reduced the response. 3 Isolated perfused lungs taken from sensitized rats released, on challenge with the sensitizing antigen, histamine, 5-hydroxytryptamine, slow reacting substance of anaphylaxis (SRS-A) and prostaglandins, but no rabbit aorta contracting substance (RCS). 4 Disodium cromoglycate inhibited both anaphylactic bronchoconstriction in vivo and the anaphylactic release of mediators in vitro. Inhibition in vivo was dose-related. 5 Mediators from the intestine, the primary shock organ of anaphylaxis in the rat, did not contribute to the lung response. 6 Vagal reflex pathways were found not to be important in PLA in vivo. 7 The relationship between the mediators released following antigen challenge of passively sensitized rat lung in vitro and passive lung anaphylaxis in vivo is discussed.

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The release of spasmogenic substances from human chopped lung tissue and its inhibition

Cited by 107 publications

References 18 publications

Spontaneous Activity in the Trachea of Dogs Treated With Indomethacin: An Experimental Model for Aspirin‐related Asthma

Spontaneous Activity in the Trachea of Dogs Treated With Indomethacin: An Experimental Model for Aspirin‐related Asthma

The Effects of the Immunologic Release of Histamine upon Human Lung Cyclic Nucleotide Levels and Prostaglandin Generation

Mediators of Passive Lung Anaphylaxis in the Rat

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