The Relevance of Animal Models in Osteoarthritis

Osteoarthritis in cynomolgus macaques: A primate model of naturally occurring disease

“…Although all experimental models of OA induce changes simulating components of the OA process, extrapolation of results to the human condition should be done with caution (26,35,37,42). While this is true for any animal model of OA, naturally occurring OA, because of its insidious development, probably simulates the human condition more closely than acutely induced disease.…”

Patient-specific knee joint finite element model validation with high-accuracy kinematics from biplane dynamic Roentgen stereogrammetric analysis

“…Knee ligament injuries and other aspects of knee mechanics are known to influence the development and progression of OA (Daniel et al, 1994;Lawrence et al, 1998;Moskowitz, 1990). In spite of this large body of evidence supporting the link between mechanical factors and OA, the specific mechanistic nature of damaging in vivo joint kinematics/loads remains elusive.…”