The Relevance of Brain Natriuretic Peptides Investigation in Various Cardiovascular Diseases

Abstract

Background: Brain natriuretic peptides are relevant markers of heart impairment. Aim: We investigated the relevance of investiging brain natriuretic peptides (NT-proBNP, BNP) in monitoring different types of cardiovascular disease (chronic heart failure due to coronary artery disease, cardiomyopathy, acquired valve disease, congenital heart diseases).Methods: The NT-proBNP assay (Roche) was performed on 280 patients (mean age 49 years; range 20-89 years) and 48 healthy controls (mean age 43 years; range 13-65 years) and BNP assay (Bayer Shionoria) was performed in a subgroup of 42 patients (mean age 50 years; range 20-79 years). Patients were divided into four groups characterized by severity of heart failure according to the New York Heart Association classification.Results: NT-proBNP concentrations differed in patients with cardiovascular diseases from controls (median 371 ng/l versus 41.5 ng/l, p < 0.0001). The cut off value of NT-proBNP determined in 280 patients with cardiovascular diseases was at 130 ng/l (AUC-area under curve = 0.93; sensitivity 98 %; specificity 79 %). Comparison of NT-proBNP and BNP values in patients showed significant correlation (r = 0.93; p < 0.0001). NT-proBNP showed significant differences between groups.Conclusions: Measurement of brain natriuretic peptides is useful and relevant in various types of heart diseases including congenital.

Evidence for Natriuretic Peptides a and B as Non-Invasive Markers in Congenital and Valvular Heart Disease

“…The present results confirm the findings of other studies showing significantly elevated levels of natriuretic peptides in various types of congenital and valvular heart diseases [3][4][5] . Other studies have shown a relationship between concentrations of natriuretic peptides and severity of heart failure [6][7][8][9][10][11][12] . In agreement with previous publications [6][7][8][9][10][11][12] , the levels of both natriuretic peptides increased with severity of the heart impairment.…”

“…Other studies have shown a relationship between concentrations of natriuretic peptides and severity of heart failure [6][7][8][9][10][11][12] . In agreement with previous publications [6][7][8][9][10][11][12] , the levels of both natriuretic peptides increased with severity of the heart impairment. The highly significant relationship to age and gender for both natriuretic peptides found, accords with other studies [13][14][15][16][17][18] .…”

NT-proBNP levels and their relationship with systemic ventricular impairment in adult patients with transposition of the great arteries long after Mustard or Senning procedure

“…Natriuretic peptides are widely used for the diagnosis of heart failure, for monitoring the efficacy of the treatment, or as a prognostic marker in the general population with cardiovascular diseases as well as in adults with congenital heart disease [2][3][4][5][6][7][8].…”

Angstausprägung, Inflammation und neurohumorale Aktivierung bei systolischer und diastolischer Dysfunktion

“…Steigende Werte stehen in Wechselbeziehung mit der Mortalität und Morbidität; es ist demzufolge als Marker von prognostischer Bedeutung (Anand et al 2003). In zahlreichen Studien wurde der Nutzen der BNP-Bestimmung bei kardiovaskulären Erkrankungen nachgewiesen (hier beispielsweise Kotaska et al 2006). Man kann BNP als einen quantitativen Marker ansehen; umso höher das BNP, desto höher ist die Wahrscheinlichkeit, dass eine Herzinsuffizienz vorliegt (Mueller et al 2007).…”