The relevance of neutrophil chemotactic factors to allergic disease

Wasserman, Stephen I.

doi:10.1016/0091-6749(79)90137-4

Cited by 11 publications

(3 citation statements)

References 32 publications

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“…IgE-class antibodies have been demonstrated to me diate non-immediate-type skin reactions [9]. The release of neutrophil chemotactic fac tors) from mast cells in IgE-mediated aller gy, persisting for up to 24 h after activation [10], might account for the late bronchial obstruction and possibly for the signs of sys temic involvement. On the other hand, in spite of the fact that during the provocation tests with chloramine-T no alveolar reac tions were observed, as in allergic alveolitis, the timing fo the late bronchial reaction and the occurrence of systemic reactions raise the possibility that complement is involved, activated by immune complexes consisting of specific IgG-class antibodies [7] and of specific IgE-class antibodies [11].…”

Section: Discussionmentioning

confidence: 99%

Occupational Asthma Due to Inhalation of Chloramine-T

Dijkman¹,

Ph²,

Kramps³

1981

Int Arch Allergy Immunol

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Respiratory symptoms developed in 5 patients who were exposed to chloramine-T, a potent disinfectant used in cleaning butcheries, kitchens, and operating theaters. Skin tests, performed in 4 patients, showed an immediate type of wheal and flare reaction followed by a late-type infiltrative reaction. In 3 patients, inhalation tests with chloramine-T were done. 1 patient showed asthmatic bronchial obstruction, immediately after inhalation, followed by a late-type asthmatic reaction after some hours. 2 patients only exhibited late-type reactions, 4–8 h after challenge. The late bronchial response lasted for several hours or even days and was accompanied by leukocytosis in all 3 patients and a slight fever in 1 patient. No evidence of alveolar involvement appeared. Pre-challenge inhalation of cromoglycate in 1 patient ameliorated the late response considerably.

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Section: Discussionmentioning

confidence: 99%

Occupational Asthma Due to Inhalation of Chloramine-T

Dijkman¹,

Ph²,

Kramps³

1981

Int Arch Allergy Immunol

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“…The late broncho-obstructive reaction might be induced by an IgE-mediated release of chemotactic factors and other mediators from mast cells and basophils as described by Dolovich et al [13] and by Solley et al [14] in case of the late cutaneous response. Recently, indications were found that mast cell-dependent neutrophil chemoattractant factors are implicated in the late phase of the immediate hypersensitivity reaction [15] .…”

Section: Discussionmentioning

confidence: 99%

Occupational Asthma Due to Inhalation of Chloramine-T

Ja¹,

Aw²,

Ph³

et al. 1981

Int Arch Allergy Immunol

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In the sera of patients who developed asthmatic symptoms after exposure to chloramine-T, specific IgE antibodies are demonstrated by a polystyrene tube radio-immunoassay. These antibodies are directed against human serum albumin treated with chloramine-T. Specific antibodies of subclasses IgG1, IgG3 and IgG4 were not found. Histamine release in response to chloramine-T-treated human serum albumin was. demonstrated using the peripheral blood leukocytes of one of the patients. To define the antigenic determinant to which the specific IgE antibodies are directed, radioimmunoassay and radioimmunoassay-inhibition studies were performed using several autologous and heterologous chloramine-T-treated proteins. Moreover, the inhibition capacities of chloramine-T and structurally related compounds were also determined. The results of these experiments indicate that the antigenic determinant is formed, at least in part, by the p-toluenesulfonyl group of the chloramine-T molecule.

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“…The mediators of late responses remain unknown but are a subject of intense investigation. 25 26 The observations that chemotactic substances including neutrophil chemotactic factor (NCF) and eosinophil chemotactic factor of anaphylaxis (ECF-A) are released in the IgE-dependent reaction have been taken to indicate the possibility that the resulting wave of inflammatory cell infiltration could be responsible for late responses. The possibility that the response is caused by injury produced by liberation from eosinophil granules of major basic protein27 is clinically attractive in view of the close relationship of the eosinophil to naturally occurring asthma but this remains unproven.…”

Section: Inducersmentioning

confidence: 99%