The relevance of organelle interactions in cellular senescence

Huang, Jiewu; Meng, Ping; Wang, Cheng; Zhang, Yunfang; Zhou, Lili

doi:10.7150/thno.70588

Cited by 22 publications

(12 citation statements)

References 212 publications

(428 reference statements)

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“…Organelles can actively communicate and cooperate with each other through vesicle trafficking pathways and membrane contact points (MCSs) to maintain cellular homeostasis, which facilitates the exchange of metabolites and other information required for normal cellular physiology ( 223 ). Imbalances in organelle interactions may lead to various pathological processes, such as imbalances in cellular energy metabolism ( 224 ). Recent studies have shown that mitochondria could interact with various organelles ( 225 ), which are essential for energy metabolism and cell survival, and increasing evidence shows that mitochondrial dysfunction in skeletal muscle and mitochondrial overactivation may induce IR ( 226 ).…”

Section: The Mechanism Of Irmentioning

confidence: 99%

The crucial role and mechanism of insulin resistance in metabolic disease

et al. 2023

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Insulin resistance (IR) plays a crucial role in the development and progression of metabolism-related diseases such as diabetes, hypertension, tumors, and nonalcoholic fatty liver disease, and provides the basis for a common understanding of these chronic diseases. In this study, we provide a systematic review of the causes, mechanisms, and treatments of IR. The pathogenesis of IR depends on genetics, obesity, age, disease, and drug effects. Mechanistically, any factor leading to abnormalities in the insulin signaling pathway leads to the development of IR in the host, including insulin receptor abnormalities, disturbances in the internal environment (regarding inflammation, hypoxia, lipotoxicity, and immunity), metabolic function of the liver and organelles, and other abnormalities. The available therapeutic strategies for IR are mainly exercise and dietary habit improvement, and chemotherapy based on biguanides and glucagon-like peptide-1, and traditional Chinese medicine treatments (e.g., herbs and acupuncture) can also be helpful. Based on the current understanding of IR mechanisms, there are still some vacancies to follow up and consider, and there is also a need to define more precise biomarkers for different chronic diseases and lifestyle interventions, and to explore natural or synthetic drugs targeting IR treatment. This could enable the treatment of patients with multiple combined metabolic diseases, with the aim of treating the disease holistically to reduce healthcare expenditures and to improve the quality of life of patients to some extent.

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Section: The Mechanism Of Irmentioning

confidence: 99%

The crucial role and mechanism of insulin resistance in metabolic disease

et al. 2023

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“…Mitochondrial quality control (MQC) is an elaborate mechanism to maintain homeostasis, ensuring the enough numbers of functional mitochondria ( Pickles et al, 2018 ; Huang et al, 2022b ). Involving mitochondrial biogenesis, dynamics, and mitophagy, mitochondrial homeostasis is intimately correlated with normal kidney function ( Rahman et al, 2022 ) ( Figure 1 ).…”

Section: Mitochondrial Dysfunctions In Kidney Diseasesmentioning

confidence: 99%

“…The impaired mitochondrial FAO leads to insufficient supply of ATP, but also results in lipotoxicity, which together contribute to renal fibrosis ( Lv et al, 2019 ; Miguel et al, 2021 ). In both AKI and CKD models, the FAO failure and the following lipid accumulation commonly occur in renal TECs ( Rong et al, 2021 ; Xu et al, 2022 ), which could further trigger the impairment of mitochondrial structure and function ( Huang et al, 2022b ).…”

Section: Mitochondrial Dysfunctions In Kidney Diseasesmentioning

confidence: 99%

Natural products for kidney disease treatment: Focus on targeting mitochondrial dysfunction

2023

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The patients with kidney diseases are increasing rapidly all over the world. With the rich abundance of mitochondria, kidney is an organ with a high consumption of energy. Hence, renal failure is highly correlated with the breakup of mitochondrial homeostasis. However, the potential drugs targeting mitochondrial dysfunction are still in mystery. The natural products have the superiorities to explore the potential drugs regulating energy metabolism. However, their roles in targeting mitochondrial dysfunction in kidney diseases have not been extensively reviewed. Herein, we reviewed a series of natural products targeting mitochondrial oxidative stress, mitochondrial biogenesis, mitophagy, and mitochondrial dynamics. We found lots of them with great medicinal values in kidney disease. Our review provides a wide prospect for seeking the effective drugs targeting kidney diseases.

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“…As a pivotal route for cholesterol transportation, MCSs participate in aging modulation by altering protein homeostasis, mitochondrial quality control, and lipid homeostasis (J. Huang, Meng, et al, 2022), and disrupted MCSs have also been linked to age-related diseases like neurodegeneration and CVDs. For example, ER extensively forms the MCSs with mitochondria and participates in ROS production, lipid and Ca 2+ flux, and autophagy, as well the pathogenesis of Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and other neurodegenerative diseases (Janikiewicz et al, 2018).…”

Section: Cellular Organelles and Vascular Agingmentioning

confidence: 99%

Membrane contact sites orchestrate cholesterol homeostasis that is central to vascular aging

Pang

Jin

et al. 2023

WIREs Mechanisms of Disease

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Chronological age causes structural and functional vascular deterioration and is a well‐established risk factor for the development of cardiovascular diseases, leading to more than 40% of all deaths in the elderly. The etiology of vascular aging is complex; a significant impact arises from impaired cholesterol homeostasis. Cholesterol level is balanced through synthesis, uptake, transport, and esterification, the processes executed by multiple organelles. Moreover, organelles responsible for cholesterol homeostasis are spatially and functionally coordinated instead of isolated by forming the membrane contact sites. Membrane contact, mediated by specific protein–protein interaction, pulls opposing organelles together and creates the hybrid place for cholesterol transfer and further signaling. The membrane contact‐dependent cholesterol transfer, together with the vesicular transport, maintains cholesterol homeostasis and has intimate implications in a growing list of diseases, including vascular aging‐related diseases. Here, we summarized the latest advances regarding cholesterol homeostasis by highlighting the membrane contact‐based regulatory mechanism. We also describe the downstream signaling under cholesterol homeostasis perturbations, prominently in cholesterol‐rich conditions, stimulating age‐dependent organelle dysfunction and vascular aging. Finally, we discuss potential cholesterol‐targeting strategies for therapists regarding vascular aging‐related diseases.This article is categorized under: Cardiovascular Diseases > Molecular and Cellular Physiology

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The relevance of organelle interactions in cellular senescence

Cited by 22 publications

References 212 publications

The crucial role and mechanism of insulin resistance in metabolic disease

The crucial role and mechanism of insulin resistance in metabolic disease

Natural products for kidney disease treatment: Focus on targeting mitochondrial dysfunction

Membrane contact sites orchestrate cholesterol homeostasis that is central to vascular aging

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