2020
DOI: 10.1016/j.freeradbiomed.2019.11.023
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The relevance of pathophysiological alterations in redox signaling of 4-hydroxynonenal for pharmacological therapies of major stress-associated diseases

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Cited by 83 publications
(74 citation statements)
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References 348 publications
(398 reference statements)
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“…The formation of 4-HNE-protein adducts enables 4-HNE to participate in the multi-step regulation of metabolic pathways (including signaling pathways associated with activation of kinases), as well as transcription factors that are responsible for redox homeostasis (such as Ref-1, Nrf2, p53, NFκB, and Hsf1). The formation of 4-HNE-protein adducts also affects the generation of pro-inflammatory factors and anti-apoptotic proteins [58,79]. Moreover, UV radiation impacts epidermal cells, which respond via a cascade of inflammation markers, such as cytokines (IL-6, Il-8, TNFα) and 8-isoprostanes that can be used as an indicator of photooxidative damages to cells and the extracellular matrix [80].…”
Section: Phospholipid Metabolism In Keratinocytes Treated With Cbdmentioning
confidence: 99%
“…The formation of 4-HNE-protein adducts enables 4-HNE to participate in the multi-step regulation of metabolic pathways (including signaling pathways associated with activation of kinases), as well as transcription factors that are responsible for redox homeostasis (such as Ref-1, Nrf2, p53, NFκB, and Hsf1). The formation of 4-HNE-protein adducts also affects the generation of pro-inflammatory factors and anti-apoptotic proteins [58,79]. Moreover, UV radiation impacts epidermal cells, which respond via a cascade of inflammation markers, such as cytokines (IL-6, Il-8, TNFα) and 8-isoprostanes that can be used as an indicator of photooxidative damages to cells and the extracellular matrix [80].…”
Section: Phospholipid Metabolism In Keratinocytes Treated With Cbdmentioning
confidence: 99%
“…Similarly, lipid peroxidation products play important physiological functions, for example in gastrointestinal tract [77]. Considering the significance of the regulatory functions of 4-hydroxynonenal and other lipid peroxidation products they also start attracting interest as a target for pharmacological interventions in major stress-associated disorders [78].…”
Section: Epigenetics and Posttranslational Protein Modification Modulmentioning
confidence: 99%
“…The amount of 4-HNE protein adducts is age-dependent and negatively correlates with the amount of GSH [70,71]. Therefore, differences in GSH metabolism and overall antioxidant capacities between cancer cells and their non-malignant counterpart cells are crucial for the selective anti-cancer cytotoxic/apoptotic effects of 4-HNE, and for the oxidative stress-related anti-cancer effects of cytostatic drugs and other biomedical remedies [64,68,[72][73][74][75].…”
Section: Ros-dependent Lipid Peroxidation Productsmentioning
confidence: 99%