The relevancy of patch testing in the exploration of the cutaneous side effects of herbal medicine

Seck, B.

doi:10.7241/ourd.20211.4

Cited by 2 publications

(2 citation statements)

References 7 publications

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“…For national use, since the Korean Ministry of Food and Drug Safety is conducting related research (eg, multicenter analysis using common data model-based EHR, analyzing each drug-ADR pair), our team will contemplate various utilizations of RS-ADR for collecting and evaluating the research. Conversely, recent attempts to study ADRs related to herbal medicines have steadily increased [42][43][44], and we consider that it may be possible to apply RS-ADR construction to the field of herbal medicine in the future.…”

Section: Limitationsmentioning

confidence: 99%

A Data-Driven Reference Standard for Adverse Drug Reaction (RS-ADR) Signal Assessment: Development and Validation

Lee

Kim

et al. 2022

J Med Internet Res

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Background Pharmacovigilance using real-world data (RWD), such as multicenter electronic health records (EHRs), yields massively parallel adverse drug reaction (ADR) signals. However, proper validation of computationally detected ADR signals is not possible due to the lack of a reference standard for positive and negative associations. Objective This study aimed to develop a reference standard for ADR (RS-ADR) to streamline the systematic detection, assessment, and understanding of almost all drug-ADR associations suggested by RWD analyses. Methods We integrated well-known reference sets for drug-ADR pairs, including Side Effect Resource, Observational Medical Outcomes Partnership, and EU-ADR. We created a pharmacovigilance dictionary using controlled vocabularies and systematically annotated EHR data. Drug-ADR associations computed from MetaLAB and MetaNurse analyses of multicenter EHRs and extracted from the Food and Drug Administration Adverse Event Reporting System were integrated as “empirically determined” positive and negative reference sets by means of cross-validation between institutions. Results The RS-ADR consisted of 1344 drugs, 4485 ADRs, and 6,027,840 drug-ADR pairs with positive and negative consensus votes as pharmacovigilance reference sets. After the curation of the initial version of RS-ADR, novel ADR signals such as “famotidine–hepatic function abnormal” were detected and reasonably validated by RS-ADR. Although the validation of the entire reference standard is challenging, especially with this initial version, the reference standard will improve as more RWD participate in the consensus voting with advanced pharmacovigilance dictionaries and analytic algorithms. One can check if a drug-ADR pair has been reported by our web-based search interface for RS-ADRs. Conclusions RS-ADRs enriched with the pharmacovigilance dictionary, ADR knowledge, and real-world evidence from EHRs may streamline the systematic detection, evaluation, and causality assessment of computationally detected ADR signals.

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Section: Limitationsmentioning

confidence: 99%

A Data-Driven Reference Standard for Adverse Drug Reaction (RS-ADR) Signal Assessment: Development and Validation

Lee

Kim

et al. 2022

J Med Internet Res

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“…The history of hairdressing and beauty salons dates back thousands of years. Ancient Egyptians were well versed in the art of hair dyeing with vegetable dyes as early as 5000 BC [1]. Hairdressers were held in great esteem in some cultures of Africa, owing to the belief that a person's spirit occupies their hair.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of dermatoses among hairdressers and beauticians in Srinagar, the capital city of Kashmir, India

Hassan¹,

Shah²,

Saqib³

2021

Our Dermatol Online

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Background: Skin disorders among hairdressers and beauticians have been recognized as a common problem, owing to the prolonged exposure to a variety of irritants and allergens. Objectives: The aim was to study the prevalence of dermatoses among hairdressers and beauticians in Srinagar, the capital city of Kashmir, India. Methods: The study was conducted on 100 respondents from 57 salons and parlors located within the borders of the city. Detailed history taking and complete examination were performed during personal visits. Patch tests were performed with the Indian standard series on all participants. Results: The mean age of the study sample was 24.3 ± 6.3 years. 54% of the studied cases were found to suffer from one or more skin disorders. Hand eczema was the most commonly encountered dermatosis, observed in 32% of the cases. Three patterns of hand eczema were recognized: classic (14%), interdigital (6%), and threading (8%). Callosities were seen in 19% of the cases. We employed the term scissor nodule for the typical pattern of a callosity caused by the finger rings of scissors. Nail staining was encountered in 19%. The most common allergens leading to a positive patch test were found to be paraphenylenediamine (PPD) in thirteen cases, followed by a fragrance mix in nine, nickel sulfate in nine, thiuram in three, and formaldehyde in one. Conclusion: Skin disorders are common among hairdressers and beauticians. Raising awareness of these disorders and methods of their prevention among this group is imperative.

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The relevancy of patch testing in the exploration of the cutaneous side effects of herbal medicine

Cited by 2 publications

References 7 publications

A Data-Driven Reference Standard for Adverse Drug Reaction (RS-ADR) Signal Assessment: Development and Validation

A Data-Driven Reference Standard for Adverse Drug Reaction (RS-ADR) Signal Assessment: Development and Validation

Prevalence of dermatoses among hairdressers and beauticians in Srinagar, the capital city of Kashmir, India

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