The Relevant of Sex Hormone Levels and Acne Grades in Patients with Acne Vulgaris: A Cross-Sectional Study in Beijing

Zhang, Rui; Zhou, Lanhua; Lv, Meiyu; Yue, Na; Fei, Wenting; Wang, Linyuan; Liu, Zhaolan; Zhang, Jianjun

doi:10.2147/ccid.s385376

Cited by 8 publications

(9 citation statements)

References 35 publications

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“…The study by Dhaher et al showed an elevated LH/FSH ratio in up to 25% of patients, although all patients had previously been diagnosed with PCOS [33]. The result of the study presented by Zhang et al confirmed a correlation between elevated levels of FSH and the severity of acne [24]. In our study, statistical analysis also revealed higher mean ± SD FSH serum levels in acne patients compared to the healthy controls.…”

Section: Discussionsupporting

confidence: 85%

“…The result of the study presented by Zhang et al . confirmed a correlation between elevated levels of FSH and the severity of acne [ 24 ]. In our study, statistical analysis also revealed higher mean ± SD FSH serum levels in acne patients compared to the healthy controls.…”

Section: Discussionmentioning

confidence: 65%

“…Zhang et al investigated the correlation between sex hormone levels and acne grades. In their study, testosterone levels were within the normal range independent of acne severity, but an increase in the ratio of androgen to oestrogen correlated with acne grades [ 24 ]. The results of our study, which indicate a decreased testosterone serum levels in the acne group, may have been induced by groups consisting mainly of female patients.…”

Section: Discussionmentioning

confidence: 99%

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Selected hormone levels and lipid abnormalities in patients with acne vulgaris

Szybiak,

Jarzemska,

Kowalczyk

et al. 2023

pdia

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Introduction Acne vulgaris is one of the most common dermatological diseases. Hormonal imbalance affects the skin condition and results in the formation of acne vulgaris lesions. Aim To evaluate serum levels of testosterone, prolactin, luteinizing hormone (LH), follicle-stimulating hormone (FSH), triglycerides (TG), and high-density lipoprotein (HDL) in patients with acne vulgaris and compare them to healthy population. Material and methods Forty-one patients with acne vulgaris and 47 age- and body mass index (BMI)-matched controls were enrolled in the study. Results The mean ± SD testosterone serum level in the study group was 0.45 ±1.03 ng/ml in females and 4.24 ±0.68 in males and in the control group 0.73 ±2.03 ng/ml and 5.3 ±1.3 ng/ml in females and males, respectively. The prolactin serum level was 16.73 ±8.02 ng/ml in the study group and in the control group 13.74 ±8.71 ng/ml ( p = 0.011). The FSH serum level was 12.17 ±16.93 mIU/ml and 6.2 ±7.3 mIU/ml in the study and control groups, respectively ( p = 0.0001), whereas LH serum levels were 18.44 ±19.71 mIU/ml and 11.26 ±8 mIU/ml, respectively ( p = 0.2659). The HDL serum level was 65.63 ±15.67 mg/dl in the study group and 61.53 ±15.89 mg/dl in the control group ( p = 0.219), and TG levels were 175.29 ±82.15 mg/dl and 87.32 ±30.64 mg/dl, respectively ( p < 0.00001). Conclusions Our study demonstrates, that hormonal and lipid imbalance could be linked to acne vulgaris formation. Evaluation of hormonal and lipid abnormalities could help in treatment decisions and could affect the occurrence of complications and the course of acne.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 99%

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Selected hormone levels and lipid abnormalities in patients with acne vulgaris

Szybiak,

Jarzemska,

Kowalczyk

et al. 2023

pdia

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“…Recent evidence shows that systemic and distant factors may have an influence on acne as well. Some examples include noted associations with circulating androgens [ 5 , 6 , 7 ], shifts in circulating short-chain fatty acids [ 8 ], and shifts in the gut microbiome [ 9 ]. In particular, previous studies have noted that circulating hormones such as testosterone, progesterone, dihydrotestosterone, and estrogen modulate acne [ 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Correlating the Gut Microbiota and Circulating Hormones with Acne Lesion Counts and Skin Biophysical Features

Sivamani

Maloh²,

Nong³

2023

Microorganisms

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Acne vulgaris is a common inflammatory condition that is multi-factorial and impacted by both intrinsic and extrinsic features. Several previous studies have assessed for correlations between factors such as circulating hormones, stress, or the microbiome. However, there have not been any correlations specifically against lesion counts or differentiating correlations between inflammatory and non-inflammatory lesion counts. Here, we correlate several factors against acne lesions. Twenty men and women with mild to moderate acne were recruited, and their hormonal levels and their gut microbiome were collected and correlated against their inflammatory and non-inflammatory lesions of acne. Facial non-inflammatory lesions were weakly correlated to sebum excretion rate and weakly inversely correlated to forehead and cheek hydration. We examined stress through the use of a normalized peak-to-trough ratio (higher numbers indicated less stress), which correlated with skin hydration and inversely correlated with sebum excretion rate. Sebum excretion rate was weakly correlated to testosterone levels, and facial hydration correlated with estradiol levels. Correlations with the gut microbiome showed differential correlations with inflammatory and non-inflammatory lesions, with Clostridium sp AF 23-8 correlating to inflammatory lesion counts, while Actinomyces naeslundii str Howell 279 correlated to non-inflammatory lesions. Overall, measures of stress and circulating hormones correlate to skin biophysical properties and acne lesion counts. Also, different gut bacteria correlate with either inflammatory or non-inflammatory lesion counts. We hope that our findings stimulate further work on the gut–mind–stress–skin axis within acne.

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“…The direct inhibitory effect of androgens on inflammation arises from the activation of overlapping signalling pathways, mainly the ERK-1 or ERK-2 pathway, which ultimately modulate the expression and activity of inflammatory mediators, including the cytokines TNF-α and IL-1β as well as the C-reactive protein [ 17 , 18 ]. It has also been shown that increasing the androgen/estrogen ratio can exacerbate the severity of acne in patients with acne vulgaris [ 19 ]. In addition, sebaceous gland activity is influenced by the growth hormone, insulin, cortisol, prolactin, thyroid hormones, and adrenaline.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Hormonal Factors in Acne Vulgaris and the Course of Acne Vulgaris Treatment with Contraceptive-Based Therapies in Young Adult Women

Borzyszkowska

Niedzielska

Kozłowski

et al. 2022

Cells

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Acne vulgaris is a common chronic inflammatory skin disease, which is considered one of the diseases of civilization due to the significant influence of environmental factors on the severity and frequency of these lesions. The aim of this study was to evaluate the hormonal profile of patients before treatment and to assess selected hormonal parameters after treatment. Our first objective was to examine the correlation between the selected hormonal parameters and the severity of acne before treatment. Our second objective was to evaluate the impact of treatment with three therapies, as measured by the selected hormonal parameters and acne severity. Statistical calculations were performed using the R v.4.1.1 statistical calculation environment (IDE RStudio v. 1.4.1717) with a significance level for the statistical tests set at α = 0.05. The results showed that the women in the pre-treatment (T1) and control (C) groups had significant differences in testosterone, androstendione, FAI, SHBG, prolactin, ACTH, and cortisol concentrations. After treatment, there were still significant differences in testosterone, androstendione, FAI, and SHBG concentrations between the post-treatment (T2) and control groups. We concluded that testosterone, androstendione, and cortisol concentrations correlate with acne severity. Acne in adult women may be an important clinical marker of androgen excess syndrome and cannot be considered a transient symptom of puberty. The mainstay of acne treatment is contraceptive therapy (ethonylestradiol and drospirenone). In this study, we confirmed the effectiveness of three contraceptive-based treatments using hormonal parameters and acne severity.

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The Relevant of Sex Hormone Levels and Acne Grades in Patients with Acne Vulgaris: A Cross-Sectional Study in Beijing

Cited by 8 publications

References 35 publications

Selected hormone levels and lipid abnormalities in patients with acne vulgaris

Selected hormone levels and lipid abnormalities in patients with acne vulgaris

Correlating the Gut Microbiota and Circulating Hormones with Acne Lesion Counts and Skin Biophysical Features

Evaluation of Hormonal Factors in Acne Vulgaris and the Course of Acne Vulgaris Treatment with Contraceptive-Based Therapies in Young Adult Women

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