The Reliability of Frozen-Section Diagnosis in Various Breast Lesions: A Study Based on 3451 Biopsies

Agnantis, Niki J.; Apostolikas, N.; Christodoulou, I.; Petrakis, C.; Garas, J

doi:10.1007/978-3-642-82031-1_29

Cited by 13 publications

(2 citation statements)

References 3 publications

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“…The decrease in accuracy of FS is due to several reasons, namely mammography and patients' awareness that make it possible to detect small lesions not easily observed on gross examination, along with a parallel increase in false-negative and deferred diagnoses. 7,9,16 Concerning IOC the usefulness of this technique has been much debated. Some authors, -2o considered the accuracy of this technique poor when compared to traditional FS.…”

Section: Discussionmentioning

confidence: 99%

Intraoperative cytology in breast cancer diagnosis: Comparison between cytologic and frozen section techniques

Rosa¹,

Boschi²,

Boscaino³

et al. 1993

Diagnostic Cytopathology

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The diagnostic accuracy of frozen section (FS) examination and intraoperative cytology (IOC) has been compared in two different series of breast biopsies in which only one of the two methods has been used. The intraoperative results have been compared with the final histological diagnoses. Five-hundred-ten cases have been investigated by using FS only, and 407 by means of IOC. The two series were comparable because they included the same pathologies; moreover we have subdivided each series into four groups of pathologies to better evaluate the diagnostic accuracy of two methods. The total diagnostic accuracy of FS has been 93.13% vs. 95.33% of IOC. The value of diagnostic accuracy of FS and IOC in the four sub-groups substantially overlapped; there was only a little difference in the group of "various lesions" in which the diagnostic accuracy of IOC was higher. No false positive has been observed in IOC. FS have produced one false positive (0.19%), whereas false negatives have amounted to 1.77% for IOC and to 1.72% for FS. Deferred diagnoses have been 2.95% in IOC and 4.90% in FS examination. For both methods according to Galen and Gambino the following values have been calculated: sensitivity, specificity, efficiency, and predictive value. By comparing the data, the value of the cytological examination in the intraoperative diagnoses results is evident mainly when the latter is coupled with the gross observation.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionmentioning

confidence: 99%

Intraoperative cytology in breast cancer diagnosis: Comparison between cytologic and frozen section techniques

Rosa¹,

Boschi²,

Boscaino³

et al. 1993

Diagnostic Cytopathology

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“…Overall accuracy rates were found to be between 83.1 to 94.3% 1-36 Lang et al 1 emphasised that these rates are consistently lower than accuracy rates of frozen section in other types of surgery7 8 including breast surgery 910Farmer et al 11 reported 91.0% accuracy of frozen section diagnosis in neuropathology.…”

mentioning

confidence: 99%

Frozen section in pituitary surgery

Har‐El

Rao

Swanson

et al. 1997

Journal of Neurology, Neurosurgery & Psychiatry

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Standardized Processing of Native Tissue in Breast Pathology

Dämmrich

Kreipe

2015

Pre-Analytics of Pathological Specimens in Oncology

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In breast surgery, replacement of intraoperative frozen section by core needle and vacuum biopsies hampers collections of unfixed breast specimens. We practice immediate intraoperative macroscopic analysis of resection margins and vacuum-cooling of breast specimens to enable native tissue asservation for assessment of biological markers and tissue banking of tumor tissue. In addition, slicing of native tissue before formalin fixation guarantees a standardized and uniform fixation. Starting in 2013, more than 350 breast specimens were processed as native specimens in the Institute of Pathology of Hannover Medical School. Breast specimens with an invasive carcinoma and request of an intraoperative resection margin assessment were processed with an immediate intraoperative pathological analysis. All other breast specimens without assessment of an intraoperative resection margin were vacuum-fixed processed. In all cases, native tissue for biomarker analyses and tumor banking could be preserved.

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The Reliability of Frozen-Section Diagnosis in Various Breast Lesions: A Study Based on 3451 Biopsies

Cited by 13 publications

References 3 publications

Intraoperative cytology in breast cancer diagnosis: Comparison between cytologic and frozen section techniques

Intraoperative cytology in breast cancer diagnosis: Comparison between cytologic and frozen section techniques

Frozen section in pituitary surgery

Standardized Processing of Native Tissue in Breast Pathology

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