The reliability of the SADS-LA in a family study setting

Leboyer, Marion; Maier, Wolfgang; Teherani, Mardjane; Lichtermann, Dirk; d’Amato, Thierry; Franke, Petra; Lépine, Jean‐Pierre; Minges, Jürgen; McGuffin, Peter

doi:10.1007/bf02219716

Cited by 77 publications

(55 citation statements)

References 12 publications

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“…Family studies Bertelsen and Gottesman, 1995] have shown schizoaffective disorder to be in the familial spectrum of both schizophrenia and bipolar disorder, and probably bearing liability to both disorders . Moreover, the reliability of the schizoaffective diagnosis is low in several studies [Maziade et al, 1992;Hostetter et al, 1983;Leboyer et al, 1991;McGorry et al, 1990;Fennig et al, 1994]. Incidentally, Antonarakis et al [1995], Mowry et al [1995], and Moises et al [1995] also included schizoaffective disorder in the affection definition that yielded modest positive linkage trends at 6p24-22.…”

Section: Discussionmentioning

confidence: 92%

6p24–22 Region and Major Psychoses in the Eastern Quebec Population

et al. 1997

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Recent reports of a linkage trend in 6p24-22 for schizophrenia (SZ), in different samples, were tempered by the concurrent evidence of negative reports in other samples. In the studies showing positive results, different definitions of affection and a wide spectrum of diagnoses were used. Our objectives were not only to test for linkage at 6p24-22 in the Eastern Quebec population, but also to test whether this putative vulnerability locus was either selectively linked to schizophrenia (SZ), or to bipolar disorder (BP), or to both major psychoses. Parametric and nonparametric linkage analyses with 12 microsatellite markers in 6p24-p22 were performed on a sample of 18 large multigenerational pedigrees (N = 354) either affected by SZ, or by BP, or equally affected by both major psychoses (i.e., mixed pedigrees). Three affection definitions were usually tested in our program: one on schizophrenia (SZ), one on bipolar disorder (BP), and one that comprised SZ and BP under the hypothesis of a susceptibility locus common to both in major psychoses (common locus, CL). The results of parametric analyses did not support a major gene hypothesis. However, in one large mixed pedigree (#151), we observed with the common locus phenotype (CL) lod scores of 2.49 and 2.15, respectively, at the D6S296 and D6S277 loci under a dominant model. Our data suggest the presence of a potential vulnerability locus at 6p24-22 that could be related to both schizophrenia and bipolar affective disorder. These results may be seen as congruent with former studies that used schizoaffective as well as schizophrenia diagnoses as entry criteria for the affected families, and used an affection definition that comprised affective psychoses as well as schizophrenia.

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Section: Discussionmentioning

confidence: 92%

6p24–22 Region and Major Psychoses in the Eastern Quebec Population

et al. 1997

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“…The French translation of the DIGS (Leboyer et al, 1995) revealed excellent inter-rater reliability in terms of kappa and Yule's Y coefficients for major mood and psychotic disorders (Preisig et al, 1999), and for SUD (Berney et al, 2002); the 6-week test-retest reliability was lower but still in the fair to good range (Berney et al, 2002;Preisig et al, 1999). The anxiety sections of the French version of the SADS-LA also revealed satisfactory inter-rater and test-retest reliability (Leboyer et al, 1991).…”

Section: Psychiatric Evaluationmentioning

confidence: 89%

Associations between mood, anxiety or substance use disorders and inflammatory markers after adjustment for multiple covariates in a population-based study

Glaus

Vandeleur

Känel

et al. 2014

Journal of Psychiatric Research

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Inflammation is one possible mechanism underlying the associations between mental disorders and cardiovascular diseases (CVD). However, studies on mental disorders and inflammation have yielded inconsistent results and the majority did not adjust for potential confounding factors. We examined the associations of several pro-inflammatory cytokines (IL-1β, IL-6 and TNF-α) and high sensitive C-reactive protein (hsCRP) with lifetime and current mood, anxiety and substance use disorders (SUD), while adjusting for multiple covariates. The sample included 3719 subjects, randomly selected from the general population, who underwent thorough somatic and psychiatric evaluations. Psychiatric diagnoses were made with a semi-structured interview. Major depressive disorder was subtyped into "atypical", "melancholic", "combined atypical-melancholic" and "unspecified". Associations between inflammatory markers and psychiatric diagnoses were assessed using multiple linear and logistic regression models. Lifetime bipolar disorders and atypical depression were associated with increased levels of hsCRP, but not after multivariate adjustment. After multivariate adjustment, SUD remained associated with increased hsCRP levels in men (β = 0.13 (95% CI: 0.03,0.23)) but not in women. After multivariate adjustment, lifetime combined and unspecified depression were associated with decreased levels of IL-6 (β = -0.27 (-0.51,-0.02); β = -0.19 (-0.34,-0.05), respectively) and TNF-α (β = -0.16 (-0.30,-0.01); β = -0.10 (-0.19,-0.02), respectively), whereas current combined and unspecified depression were associated with decreased levels of hsCRP (β = -0.20 (-0.39,-0.02); β = -0.12 (-0.24,-0.01), respectively). Our data suggest that the significant associations between increased hsCRP levels and mood disorders are mainly attributable to the effects of comorbid disorders, medication as well as behavioral and physical CVRFs.

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“…The French version of this instrument also revealed adequate inter-rater and test-retest reliability for major mood (Preisig et al, 1999) and substance use disorders (Berney et al, 2002). The DIGS was completed with sections on generalized anxiety disorder and phobias using questions from the Schedule for Affective Disorders and SchizophreniaLifetime and anxiety disorder version (SADS-LA (Endicott and Spitzer, 1978)), which also revealed satisfactory test-retest reliability (Leboyer et al, 1991;Rougemont-Buecking et al, 2008). At baseline lifetime diagnoses and at follow-up the diagnosis of MDD since baseline were assigned according to the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV) (American Psychiatric Association, 2000).…”

Section: Depression Status and Comorbid Mental Disordersmentioning

confidence: 98%