The REM sleep behavior disorder screening questionnaire: Validation study of a Japanese version

Miyamoto, Tomoyuki; Miyamoto, Masayuki; Iwanami, Masaoki; Kobayashi, Mina; Nakamura, Masaki; Inoue, Yuichi; Ando, Chiharu; Hirata, Koichi

doi:10.1016/j.sleep.2009.05.007

Cited by 129 publications

(124 citation statements)

References 6 publications

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“…Therefore, a convenient and suitable screening tool is needed for epidemiological research and clinical screening (Lam et al 2013). A limited number of questionnaires developed for screening RBD have been applied in Chinese populations (StiasnyKolster et al 2007;Miyamoto et al 2009;Li et al 2010;Boeve et al 2011Boeve et al , 2013Neikrug and Ancoli-Israel 2012;Postuma et al 2012;Sasai et al 2012;Lam et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Validation of the Beijing Version of the REM Sleep Behavior Disorder Questionnaire (RBDQ-Beijing) in a Mainland Chinese Cohort

Chang

Zhan

et al. 2014

Tohoku J. Exp. Med.

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REM sleep behavior disorder (RBD) is one type of parasomnia characterized by nocturnal complex motor activity associated with dream mentation. Growing evidence has indicated that RBD is a preclinical stage of neurodegenerative diseases. Therefore screening RBD patient is becoming important. The RBD Questionnaire-Hong Kong (RBDQ-HK) is an effective questionnaire to screen RBD patients. However, it is hard to distinguish RBD with the questionnaire from severe OSAS patients, who could mimic some symptoms of RBD patients. Therefore, we made RBDQ-Beijing by adding two screening questions for OSAS into original RBDQ-HK, including habitual loud snoring and witnessed apnea during sleep. To validate and compare these two questionnaires, 224 subjects were enrolled and screened with these questionnaires, and consequently analyzed with video-polysomnography. Receiver-operator characteristics curve analysis was conducted to attain the best cut-off values of the RBDQ-HK and RBDQ-Beijing. For the RBDQ-HK, the sensitivity was 97.1% and the specificity was 83.2%. More than half of misclassified RBD patients were proved to be severe OSAS patients. For the RBDQ-Beijing, the sensitivity was 95.8% and specificity was 94.3%, indicating that our questionnaire is able to distinguish RBD from severe OSAS patients. In conclusion, RBDQ-Beijing is of help to improve the specificity in RBD screening without excluding the patients with RBD combined OSAS. Therefore the RBDQ-Beijing may be a better screening and preliminary diagnostic tool for RBD than the RBDQ-HK. Moreover, the RBDQ-Beijing would be important for early diagnosis of neurodegenerative diseases and for prevention of injuries to the patient or the patient's bed partner.

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Section: Introductionmentioning

confidence: 99%

Validation of the Beijing Version of the REM Sleep Behavior Disorder Questionnaire (RBDQ-Beijing) in a Mainland Chinese Cohort

Chang

Zhan

et al. 2014

Tohoku J. Exp. Med.

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“…The mean H&Y stage was 2.4 ± 0.8 (1-3), and the mean UPDRS part III subscale score was 18.8 ± 10.6 (2-38); these data indicate that no participant with severe PD was recruited in this study. The mean RBDSQ-J score was 5.3 ± 3.1, and 14 subjects scored <5, which is regarded as RBD negative [23]. All subjects showed reduced myocardial 123 I-MIBG uptake (below the cut-off of 2.20 [21]), indicating that they have PD with a Lewy body disorder [25].…”

Section: Resultsmentioning

confidence: 99%

“…We carried out cognitive performance measurements including baseline and longitudinal performance on the MoCA-J, and the criteria for PD-MCI were consistent with those of the Movement Disorder Society. We also performed olfactory disturbance screening with the Odor Stick Identification Test for Japanese [22] and administered the REM sleep behavior disorder (RBD) Screening Questionnaire for Japanese (RBDSQ-J) [23]. …”

Section: Methodsmentioning

confidence: 99%

Extremely Low Prevalence of Amyloid Positron Emission Tomography Positivity in Parkinson's Disease without Dementia

Mashima¹,

Ito²,

Kameyama

et al. 2017

Eur Neurol

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Background: Most cases of dementia with Lewy bodies (DLB) show Alzheimer's disease pathology-like senile plaques and neurofibrillary tangles. Several studies have also revealed a high prevalence of positive amyloid imaging with positron emission tomography (PET) in DLB and moderate prevalence in Parkinson's disease (PD) with dementia. However, it remains unclear in PD without dementia as to when the brain β amyloid (Aβ) burden begins and progresses. Our study aimed to determine the prevalence of Aβ deposition in PD without dementia using amyloid PET. Methods: This was a cross-sectional study on 33 patients with PD without dementia, of whom 21 had normal cognition and 12 met the criteria for PD-mild cognitive impairment. All subjects underwent neuropsychological assessment and [¹⁸F] florbetaben (FBB) PET. Results: All subjects had Lewy body-related disorders, displaying a significantly reduced myocardial [¹²³I] metaiodobenzylguanidine uptake. The cortical FBB-binding pattern in all subjects, including APOE e4 carriers, suggested negative Aβ deposition. Conclusion: Patients with PD without dementia exhibit an extremely low prevalence of Aβ positivity compared with those reported in cognitively normal elderly controls. Further longitudinal imaging studies and long-term follow-up are needed; however, our findings provide novel insights for understanding Aβ metabolism in PD.

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“…It has been reported that a tremor-dominant type may transition into a non-tremor dominant type over time and with increased age [105]. In our study including 93 patients with PD and controls using the Japanese version of the RBD screening questionnaire (RBDSQ-J) [106], 29% of PD patients had probable RBD (5≥RBDSQ-J) compared with 8.6% of controls [107]. Patients with probable RBD had a higher score of PDQ-39 cognition and emotional wellbeing and more frequent sleep onset insomnia, distressing dreams, and hallucinations.…”

Section: Rapid Eye Movement Sleep Behavior Disordermentioning

confidence: 97%

Sleep Disturbances in Patients with Parkinson’s Disease

Suzuki¹,

Miyamoto²,

Miyamoto³

et al. 2014

A Synopsis of Parkinson's Disease

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The REM sleep behavior disorder screening questionnaire: Validation study of a Japanese version

Cited by 129 publications

References 6 publications

Validation of the Beijing Version of the REM Sleep Behavior Disorder Questionnaire (RBDQ-Beijing) in a Mainland Chinese Cohort

Validation of the Beijing Version of the REM Sleep Behavior Disorder Questionnaire (RBDQ-Beijing) in a Mainland Chinese Cohort

Extremely Low Prevalence of Amyloid Positron Emission Tomography Positivity in Parkinson's Disease without Dementia

Sleep Disturbances in Patients with Parkinson’s Disease

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