The REM-sleep-related characteristics of narcolepsy: a nation-wide multicenter study in Turkey, the REMCON study

Akyıldız, Utku Oğan; Tezer, F. İrsel; Koç, Güray; İsmailoğulları, Sevda; Demir, Aylin Bican; Ak, Ayşın Kısabay; Sünter, Gülin; Aslan-Kara, Kezban; Berktaş, Deniz Tuncel; Sahin, Aysenur; Azman, Filiz; Akçay, Bülent Devrim; Gök, Duygu Kurt; Yılmaz, Hikmet; Ağan, Kadriye; Bekmezci, Yavuz; Yetkin, Sinan; Aksu, M.; Karadeniz, Derya; Şenel, Gülçin Benbir

doi:10.1016/j.sleep.2022.03.025

Cited by 6 publications

(2 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other side, a short latency of REM sleep (≤15 min) at nocturnal PSG was proposed to be a highly specific positive predictive value for NT1 [24]. Similarly, a recent study showed that the percentage of SOREMP in nocturnal PSG was significantly higher in NT1 (37.1%) than in NT2, together with a shorter mean sleep latency in MSLT in patients with NT1 [25]. In sum, as proposed by European experts [18], clinical assessment, PSG, and MSLT findings are important tools in the evaluation of patients with EDS, in addition to CSF hypocretin and HLA measurements, if feasible.…”

Section: Discussionmentioning

confidence: 98%

A Turkish Validity and Reliability Study of the Swiss Narcolepsy Scale

Demir

Bargiotas

Tunçel

et al. 2023

CTN

Self Cite

View full text Add to dashboard Cite

Background: The clinical evaluation of a patient complaining of excessive daytime sleepiness is of crucial importance for the diagnosis of narcolepsy. The Swiss Narcolepsy Scale (SNS) was developed in 2004 as a screening tool for patients with narcolepsy and shown in three different studies to have a high sensitivity and specificity for narcolepsy type 1 (NT1). The aim of this study was to assess the validity and reliability of the Turkish version of SNS (SNS-TR). Patients and Methods: Twenty-one healthy controls, 26 patients with idiopathic hypersomnia, and 27 patients with narcolepsy were recruited from five accredited sleep centers in Turkey. Pearson’s correlation coefficient and degree of freedom were used to determine the validity of each question. Cronbach’s alpha was calculated to assess the internal consistency or reliability of Likert-type questions. The inter-rater reliability was tested using Cohen’s kappa analysis, and the intra-class correlation coefficient (ICC) was used to evaluate the validity and reliability between two evaluations with a one-month interval. Results: Sensitivity and specificity of SNS-TR were 90.5% and 100%, respectively, for diagnosing NT1. Cronbach’s alpha was 0.976, showing a highly reliable level of internal consistency. The inter-rater reliability of the questions and the validity and reliability between two evaluations were moderate or above. Conclusion: This study provides evidence for the validity and reliability of SNS-TR in diagnosing and discriminating NT1 from other disorders of hypersomnolence with a very high sensitivity and specificity.

show abstract

Section: Discussionmentioning

confidence: 98%

A Turkish Validity and Reliability Study of the Swiss Narcolepsy Scale

Demir

Bargiotas

Tunçel

et al. 2023

CTN

Self Cite

View full text Add to dashboard Cite

show abstract

“…A plausible neuroanatomical basis for this may involve diminished orexinergic regulation of PAG, dorsal raphe nucleus (DRN), and locus coeruleus networks. Indeed, these regions are also thought to be involved in the generation, modulation, and cessation of rapid-eye-movement (REM) sleep [ 70 , 71 ], and alterations in REM sleep are reported in narcolepsy [ 72 , 73 ].…”

Section: Introductionmentioning

confidence: 99%

Orexins and primary headaches: an overview of the neurobiology and clinical impact

Stanyer,

Hoffmann,

Holland

2024

Expert Review of Neurotherapeutics

View full text Add to dashboard Cite

Introduction Primary headaches, including migraines and cluster headaches, are highly prevalent disorders that significantly impact quality of life. Several factors suggest a key role for the hypothalamus, including neuroimaging studies, attack periodicity, and the presence of altered homeostatic regulation. The orexins are two neuropeptides synthesized almost exclusively in the lateral hypothalamus with widespread projections across the central nervous system. They are involved in an array of functions including homeostatic regulation and nociception, suggesting a potential role in primary headaches. Areas covered This review summarizes current knowledge of the neurobiology of orexins, their involvement in sleep-wake regulation, nociception, and functions relevant to the associated symptomology of headache disorders. Preclinical reports of the antinociceptive effects of orexin-A in preclinical models are discussed, as well as clinical evidence for the potential involvement of the orexinergic system in headache. Expert opinion Several lines of evidence support the targeted modulation of orexinergic signaling in primary headaches. Critically, orexins A and B, acting differentially via the orexin 1 and 2 receptors, respectively, demonstrate differential effects on trigeminal pain processing, indicating why dual-receptor antagonists failed to show clinical efficacy. The authors propose that orexin 1 receptor agonists or positive allosteric modulators should be the focus of future research.

show abstract