The remarkable crystal structure of the dimeric species [bis(ortho-anisyl)magnesium · THF]2

Markies, Peter R.; Schat, G.; Villena, Alan; Akkerman, Otto S.; Bickelhaupt, F.; Smeets, W. J. J.; Spek, Anthony L.

doi:10.1016/0022-328x(91)83036-4

Cited by 7 publications

(2 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The reaction of IC complexes [50][51][52][53][54][55] with MgEt2 lead to the formation of ethyl(4-alkoxybutyl)magnesium compounds 56 NMR spectra of Mg(C4H8OR)2 compounds with that ofMgEt2*2THF, deshielding of the signals of the ethyl Mg-CH2 protons of 0.05-0.13 ppm is observed. The oxygen coordination in the alkoxybutyl inner complexes is apparently stronger than in the THF adduct.…”

Section: Scheme 35mentioning

confidence: 99%

Intramolecular Coordination in Organometallic Compounds of Groups 2, 12, and 13

Gruter¹,

Klink²,

Akkerman³

et al. 1995

Chem. Rev.

Self Cite

View full text Add to dashboard Cite

Section: Scheme 35mentioning

confidence: 99%

Intramolecular Coordination in Organometallic Compounds of Groups 2, 12, and 13

Gruter¹,

Klink²,

Akkerman³

et al. 1995

Chem. Rev.

Self Cite

View full text Add to dashboard Cite

“…In 2 and 3 , the mean Mg– ortho -C bond length (2.198 Å) lies at the top end of the range of corresponding bonds (2.132(6)–2.199(7) Å) in the unsymmetrical dimer [Mg{bis( ortho -anisyl)}(thf)] 2 , the only previously reported C-magnesiated anisole structure—made not by direct magnesiation but through transmetalation from the mercury analogue. 20 Corresponding bonds involving K in 2 and 3 show little variation [e.g., d (K–N(TMP))=2.948(4) Å and 3.005(6) Å, respectively; mean d (K–N(PMDETA))=2.907 Å and 2.893 Å, respectively] with the exception of the dative K–O bonds ( d =3.071(5) Å and 2.843(6) Å, respectively). Probably as an artifact of the making of these ring closing K–O bonds, close topological contacts exist between K and the ipso / ortho (-magnesiated) C atoms of the anisole ligands ( d =3.216(5)/3.187(5) Å for 2 ; d =3.162(8)/3.190(8) Å for 3 ).…”

mentioning

confidence: 99%

Structural Tracking of the Potassium‐Mediated Magnesiation of Anisole

Clegg

Conway

García‐Álvarez

et al. 2009

Chemistry A European J

View full text Add to dashboard Cite

Although a number of infants with maternal uniparental disomy of chromosome 16 (upd(16)mat) have been reported, the evidence for imprinting on chromosome 16 is not yet conclusive. To test the hypothesis that upd(16)mat has a distinct phenotype, which would support the existence of imprinted gene(s) on chromosome 16, statistical analysis was performed on a large series (n = 83) of mosaic trisomy 16 cases with molecular determination of uniparental disomy status. The incidence of upd(16)mat was 40%, which is consistent with the expected one third from random chromosome loss during trisomy rescue (P = 0.262). In pairwise comparisons, upd(16)mat was found to be associated with fetal growth restriction (P = 0.029) and with increased risk of major malformation (RR = 1.43; P = 0.053). Regression modeling showed that the effect of upd(16)mat on fetal/neonatal weight and malformation is independent of the degree of trisomy detected in the fetus. Regression modeling to control for the degree of trisomy detected in the placenta was not possible due to limited sample size. We conclude that upd(16)mat is associated with more severe growth restriction, and possibly, with higher risk of malformation. Our hypothesis is that imprinted gene(s) exist on chromosome 16 and that abnormal expression of these gene(s) in upd(16)mat cells during development results in decreased cell proliferation. Although we do not advocate prenatal testing for upd(16), studies on the long‐term outcome of upd(16)mat neonates is necessary for counseling purposes. © 2002 Wiley‐Liss, Inc.

show abstract