The remodeling of alveolar bone supporting the mandibular first molar with different levels of periodontal attachment

Zhao, Yanfang; Wang, Weifeng; Xin, Haitao; Zang, Shun-lai; Zhang, Zhiyuan; Wu, Yulu

doi:10.1007/s11517-013-1078-x

Cited by 14 publications

(11 citation statements)

References 40 publications

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“…Zhao et al . had built a FE model of lower first molar including tooth, periodontal membrane, part of cortical bone and trabecular bone, and applied a 420 N vertical force on the occlusal surface of tooth model. The results showed that the alveolar areas in buccal and lingual ridges and root apex regions experienced higher stresses when the tooth was loaded.…”

Section: Discussionmentioning

confidence: 99%

Finite element analysis on tooth and periodontal stress under simulated occlusal loads

Zhang

Cui

et al. 2017

J of Oral Rehabilitation

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The tooth stress elicited by occluding contact represents critical biomechanical information about dental health during chewing. Effects of occlusal contact on tooth stress remain obscure. In this study, a mandibular first molar finite element model was built from CT images. The effects of area size, location and direction of occlusal loading on both tooth and periodontal stresses were analysed. Results showed tooth and periodontal stress had drastically different patterns. Tooth stress value was much higher than periodontal stress value under the same task. Tooth stress concentration area and its value decreased from outside to inside. The Maximum Tooth Stress (MTS) always occurred at the loading site and a larger loading area elicited a smaller MTS value. The variation of MTS was larger when the fossa bottoms were inclined loaded than when the cusp tips were inclined loaded, larger when lingually loaded than when buccally loaded and larger when mesially loaded than when distally loaded. Distal loadings generally induced smaller Maximum Periodontal Stress (MPS) variations than the mesial loadings. These findings indicated exposure of the rational site(s) to occlusal contact should be helpful to achieve proper tooth and periodontal stress, thus to diminish loading associated structure problems.

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Section: Discussionmentioning

confidence: 99%

Finite element analysis on tooth and periodontal stress under simulated occlusal loads

Zhang

Cui

et al. 2017

J of Oral Rehabilitation

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“…As such it is constantly subjected to external mechanical stresses that cause its continuous remodeling and resorption. 1 Since spontaneous regeneration does not occur in alveolar bone, damage caused by trauma or periodontitis generally requires surgical interventions that may result in tooth loss and the need for bone grafting, accompanied by its associated risks (reviewed in Ref. 2 ).…”

Section: Introductionmentioning

confidence: 99%

Electrical Stimulation Decreases Dental Pulp Stem Cell Osteo-/Odontogenic Differentiation

Oliveira

Leppik

Keswani

et al. 2020

BioResearch Open Access

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Dental pulp stem cells (DPSCs) have great potential for use in tissue engineering (TE)-based dental treatments. Electrical stimulation (EStim) has been shown to influence cellular functions that could play an important role in the success of TE treatments. Despite many recent studies focused on DPSCs, few have investigated the effect EStim has on these cells. The aim of this research was to investigate the effects of direct current (DC) EStim on osteo-/odontogenic differentiation of DPSCs. To do so cells were isolated from male Sprague Dawley rats (7-8 weeks old), and phenotype characterization and multilineage differentiation analysis were conducted to verify their ''stemness.'' Different voltages of DC EStim were administrated 1 h/day for 7 days, and the effect of EStim on DPSC osteo-/odontogenic differentiation was assessed by measuring calcium and collagen deposition, alkaline phosphatase (ALP) activity, and expression of osteo-and odontogenic marker genes at days 7 and 14 of culture. We found that while 10 and 50 mV/mm of EStim had no effect on cell number or metabolic activity, 100 mV/mm caused a significant reduction in cell number, and 150 mV/mm resulted in cell death. Despite increased gene expression of osteo-/odontogenic gene markers, Osteocalcin, RunX2, BSP, and DMP1, at day 7 in EStim treated cells, 50 mV/mm of EStim decreased collagen deposition and ALP activity at both time points, and calcium deposition was found to be lower at day 14. In conclusion, under the conditions tested, EStim appears to impair DPSC osteo-/odontogenic differentiation. Additional studies are needed to further characterize and understand the mechanisms involved in DPSC response to EStim, with an eye toward its potential use in TEbased dental treatments.

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“…94 Under such differences in load, the supporting alveolar and maxillary bone structures undergo load-dependent bone remodeling with bone resorption seen under extreme loading. 95 Preferential binding of labeled ZOL to certain anatomical bone sites was recapitulated in animal models with distinct areas of the posterior mandible (ascending ramus and mandibular molar alveolar bone) demonstrating increased fluorescence labeling. 96 Similar anatomical differences were also seen in the femur with more labeling in the proximal area of primary spongiosa than distal region, which may explain the increased risk of avascular necrosis of the femoral head.…”

Section: Mechanism Of Actionmentioning

confidence: 92%

Mitigating osteonecrosis of the jaw (ONJ) through preventive dental care and understanding of risk factors

et al. 2020

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It is well established that alterations in phosphate metabolism have a profound effect on hard and soft tissues of the oral cavity. The present-day clinical form of osteonecrosis of the jaw (ONJ) was preceded by phosphorus necrosis of the jaw, ca. 1860. The subsequent removal of yellow phosphorus from matches in the early 20th century saw a parallel decline in “phossy jaw” until the early 2000s, when similar reports of unusual jaw bone necrosis began to appear in the literature describing jaw necrosis in patients undergoing chemotherapy and concomitant steroid and bisphosphonate treatment. Today, the potential side effect of ONJ associated with medications that block osteoclast activity (antiresorptive) is well known, though the mechanism remains unclear and the management and outcomes are often unsatisfactory. Much of the existing literature has focused on the continuing concerns of appropriate use of bisphosphonates and other antiresorptive medications, the incomplete or underdeveloped research on ONJ, and the use of drugs with anabolic potential for treatment of osteoporosis. While recognizing that ONJ is a rare occurrence and ONJ-associated medications play an important role in fracture risk reduction in osteoporotic patients, evidence to date suggests that health care providers can lower the risk further by dental evaluations and care prior to initiating antiresorptive therapies and by monitoring dental health during and after treatment. This review describes the current clinical management guidelines for ONJ, the critical role of dental-medical management in mitigating risks, and the current understanding of the effects of predominantly osteoclast-modulating drugs on bone homeostasis.

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The remodeling of alveolar bone supporting the mandibular first molar with different levels of periodontal attachment

Cited by 14 publications

References 40 publications

Finite element analysis on tooth and periodontal stress under simulated occlusal loads

Finite element analysis on tooth and periodontal stress under simulated occlusal loads

Electrical Stimulation Decreases Dental Pulp Stem Cell Osteo-/Odontogenic Differentiation

Mitigating osteonecrosis of the jaw (ONJ) through preventive dental care and understanding of risk factors

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