Appropriating and manipulating human body parts was an important component of the belief system throughout much of the world. In eastern North America, Mississippian trophy-taking behavior was predicated on beliefs that focused on human life forces believed to reside in body elements, especially the head and scalp. Archaeologists have generally neglected to apprehend the potent meanings of trophy-taking behavior as a component of indigenous belief systems. Trophy-taking has been traditionally viewed as grounded in competition over economic resources, intercommunity conflict, or the pursuit of personal status and political advancement. This essay explores how Mississippians engaged in trophy-taking behavior, including snaring life forces for religious purposes through raiding and warfare, especially mortuary programs and ritual performances that emphasized the spirit’s journey to the realm of the dead and the enduring cycle of life and death. This alternative approach embraces a multidisciplinary perspective that includes archaeology, bioarchaeology, ethnography, ethnohistory, iconography, mythology, and osteoarchaeology.