The renal and cardiodynamic effects of prostaglandins (PGE1, PGA1) in renal ischemia

Murphy, Gerald P.; Hesse, V.; Evers, John L.; Hobika, G. H.; Mostert, J. W.; Szolnoky, A; Schoonees, R; Abramczyk, J.; Grace, James T.

doi:10.1016/0022-4804(70)90079-x

Cited by 17 publications

(6 citation statements)

References 3 publications

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“…MAP, however, was significantly reduced with each dose level of PGA. Murphy et al [16] obtained approximately the same results in similar experiments. On the other hand.…”

Section: Discussionsupporting

confidence: 78%

“…Accordingly, it has been possible to produce greater reductions in renal vascular resistance by concurrent administration of a-adrenergic blocking agents and dopamine [13], More recently, intravenous administrations of prostaglandin A com pounds (PGA) have also been found to increase RBF [2,5,9,11], As with dopamine, the increase in RBF is a manifestation of small doses. Larger doses cause generalized vasodilation and reduce renal perfusion pressure [9,16], In addition, PGA has been found to antagonize the vasoconstricting actions of norepinephrine and angiotensin [8].…”

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confidence: 99%

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Systemic and Renal Hemodynamic Effects of Dopamine and Prostaglandin A alone and in Combination

Robie¹,

Goetter²,

Goldberg³

1974

J Vasc Res

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Prostaglandin A (PGA) compounds infused intravenously at rates of 0.125, 0.25 and 0.50 µg/kg/min decreased mean aortic pressure and renal vascular resistance, but did not increase renal blood flow in pentobarbital-anesthetized dogs. In contrast, dopamine increased renal blood flow at infusion rates of 2.5, 5.0 and 7.5 µg/kg/min and increased mean aortic pressure at infusion rates of 5.0 and 7.5 µg/kg/min. With simultaneous infusions of PGA (0.125 and 0.25 µg/kg/min) and dopamine (2.5, 5.0 and 7.5 µg/kg/min), mean aortic pressure decreased and renal blood flow increased. In open-chest dogs, cardiac contractile force was increased more by dopamine than by PGA. Neither agent alone altered heart rate, but when administered together, heart rate increased. PGA (0.01–0.02 µg/kg/min) abolished the increase in blood pressure produced by larger doses of dopamine (15–20 µg/kg/min) without reducing the increase in renal blood flow. Thus, by varying infusion rates of dopamine and PGA, renal blood flow may be increased with no change, an increase or a decrease in arterial pressure.

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“…MAP, however, was significantly reduced with each dose level of PGA. Murphy et al [16] obtained approximately the same results in similar experiments. On the other hand.…”

Section: Discussionsupporting

confidence: 78%

mentioning

confidence: 99%

Systemic and Renal Hemodynamic Effects of Dopamine and Prostaglandin A alone and in Combination

Robie¹,

Goetter²,

Goldberg³

1974

J Vasc Res

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“…Infusion of PGE1 into the renal artery of the dog has been reported to increase free water clearance (5-7), but whether the presence of vasopressin is necessary for such an effect to occur has not been defined. In contrast to this diuretic effect of intrarenal PGE1, the infusion of PGE, intravenously may be associated with an antidiuresis (8). Whether such an antidiuretic effect occurs as a result of the endogenous release of vasopressin (ADH), alterations in systemic and renal hemodynamics or a primary effect of the agent on the water permeability of the collecting duct is not known.…”

Section: Introductionmentioning

confidence: 99%

Mechanism of Effect of Prostaglandin E1 on Renal Water Excretion

Berl¹,

Schrier²

1973

J. Clin. Invest.

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ABS TRA CT The present study examined the effect of prostaglandin El (PGE1) on renal water excretion in the anesthetized dog. Renal perfusion pressure was kept constant by adjustment of a suprarenal aortic clamp. In seven experiments the intravenous administration of PGE1 (7 /Lg/min) significantly increased urinary osmolality from 76 to 381 mosmol (P < 0.001) and decreased free water clearance from 2.2 to -0.02 ml/ min (P < 0.001). These effects promptly were reversed with cessation of the infusion. This antidiuretic effect occurred both in innervated and denervated kidneys and was not associated with changes in glonmerular filtration rate, renal vascular resistance, or solute excretion rate. In 10 experiments in hypophysectomized dogs no effect of intravenous PGE1 on free water clearance and urinary osmolality was observed. The intrarenal administration of PGE1 (1 Ag/min) to six water-loaded and two hypophysectomized dogs caused no systemic vascular changes and increased rather than decreased free water clearance (2.83 to 4.08 ml/min, P < 0.001). No significant change in urinary osmolality occurred. Glomerular filtration rate was not altered by the intrarenal infusion, but reversible changes in solute excretion rate and renal vascular resistance occurred. These results thus indicate that the antidiuresis associated with intravenous PGE1 is mediated primarily by the release of vasopressin rather than alterations in renal hemodynamics or solute excretion. The diuretic effect of intrarenal PGE1 occurs in the absence of vasopressin and is most likely medi-A preliminary report of this work was presented at the

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“…Their effect on outer cortical flow and glomerular filtration is variable and depends on the experimental design [16,17], Both agents, however, augment filtration rate and filtration pressure in the presence of unilateral ureteral obstruction, a process known to be associated with a reduction in filtration pressure [18]. Similarly, intra-arterial infusions of both acetylcholine and bradykinin into patients with chronic renal failure is followed by increases in total renal blood flow [19], PGAi is a potent vaso dilator which, like acetylcholine and papaverine, can induce vasodilatation and an increase in renal blood flow even in the presence of induced renal ischemia [20], In addition, unlike prostaglandins of the E or F series, it is not inactivated by the lungs and hence, is effective by the intravenous or subcutaneous routes of administration [21].…”

Section: Discussionmentioning

confidence: 99%