The renal dopaminergic system, neurohumoral activation, and sodium handling in heart failure

Ferreira, António; Bettencourt, Paulo; Pimenta, Joana; Friões, Fernando; Pestana, Manuel; Soares-da-Silva, Patrı́cio; Cerqueira-Gomes, M

doi:10.1067/mhj.2002.120292

Cited by 14 publications

(6 citation statements)

References 22 publications

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“…In humans, all of the DA in urine is derived from uptake of circulating DOPA [86]. DA exiting the proximal tubular cells acts on the same or nearby cells to augment sodium excretion [87]. Most of the DA synthesized in the body is formed in non-neuronal cells in splanchnic organs, not the brain or sympathetic nervous system [88].…”

Section: Catecholamine Reactivity To Mental Stressmentioning

confidence: 99%

Sympathoneural and Adrenomedullary Responses to Mental Stress

Carter

Goldstein

2014

Comprehensive Physiology

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This concept-based review provides historical perspectives and updates about sympathetic noradrenergic and sympathetic adrenergic responses to mental stress. The topic of this review has incited perennial debate, because of disagreements over definitions, controversial inferences, and limited availability of relevant measurement tools. The discussion begins appropriately with Cannon's "homeostasis" and his pioneering work in the area. This is followed by mental stress as a scientific idea and the relatively new notions of allostasis and allostatic load. Experimental models of mental stress in rodents and humans are discussed, with particular attention to ethical constraints in humans. Sections follow on sympathoneural to mental stress, reactivity of catecholamine systems, clinical pathophysiologic states, and the cardiovascular reactivity hypothesis. Future advancement of the field will require integrative approaches and coordinated efforts between physiologists and psychologists on this interdisciplinary topic.

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Section: Catecholamine Reactivity To Mental Stressmentioning

confidence: 99%

Sympathoneural and Adrenomedullary Responses to Mental Stress

Carter

Goldstein

2014

Comprehensive Physiology

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“…The renal DOPA-DA system is upregulated in heart failure (98), possibly as part of a compensatory process. Renalase, a relatively recently described amine oxidase, metabolizes urinary catecholamines, and it has been proposed that renalase in luminal fluid might alter DA metabolism and proximal tubular sodium transport (62).…”

Section: Applications Of Concepts Of Scientific Integrative Medicine mentioning

confidence: 99%

Concepts of Scientific Integrative Medicine Applied to the Physiology and Pathophysiology of Catecholamine Systems

Goldstein

2013

Comprehensive Physiology

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This review presents concepts of scientific integrative medicine and relates them to the physiology of catecholamine systems and to the pathophysiology of catecholamine-related disorders. The applications to catecholamine systems exemplify how scientific integrative medicine links systems biology with integrative physiology. Concepts of scientific integrative medicine include (i) negative feedback regulation, maintaining stability of the body’s monitored variables; (ii) homeostats, which compare information about monitored variables with algorithms for responding; (iii) multiple effectors, enabling compensatory activation of alternative effectors and primitive specificity of stress response patterns; (iv) effector sharing, accounting for interactions among homeostats and phenomena such as hyperglycemia attending gastrointestinal bleeding and hyponatremia attending congestive heart failure; (v) stress, applying a definition as a state rather than as an environmental stimulus or stereotyped response; (vi) distress, using a noncircular definition that does not presume pathology; (vii) allostasis, corresponding to adaptive plasticity of feedback-regulated systems; and (viii) allostatic load, explaining chronic degenerative diseases in terms of effects of cumulative wear and tear. From computer models one can predict mathematically the effects of stress and allostatic load on the transition from wellness to symptomatic disease. The review describes acute and chronic clinical disorders involving catecholamine systems—especially Parkinson disease—and how these concepts relate to pathophysiology, early detection, and treatment and prevention strategies in the post-genome era.

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“…The increases in sympathetic tone seen in association with CHF are associated with poorer outcome, morbidity and mortality. These could be mediated by peripheral vasoconstriction, enhanced sodium retention, attenuated cardiovascular reflexes and increased susceptibility to arrhythmia and/or sudden death [15][16][17][18]. Accordingly we have used HRV studies to assess the impact of Atorvastatin on autonomic tone in SHF Methods 23 consecutive patients from our systolic heart failure clinic (19 men and 3 women; mean age 67 ± 10 years) with stable systolic left ventricular impairment (documented ejection fraction (EF) <45% on radionuclide ventriculography and/or echocardiography) and who were not currently on statin therapy were randomised single (patient) blind to receive either Atorvastatin (40 mg/day) or to continue with their usual regimen of SHF treatment with a placebo.…”

Section: Introductionmentioning

confidence: 98%