The renal excretion of selenium

Oster, O.; Prellwitz, W.

doi:10.1007/bf02917201

Cited by 68 publications

(37 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The amount of selenium excreted in the urine depends on the level of selenium intake, its chemical form, the composition of the diet, the physiological and selenium status of the animals and on the glomerular filtration rate of the kidneys [4,10,18]. A considerably larger proportion of the organic forms of selenium was found to be retained in the body, in contrast to inorganic forms which are absorbed rapidly but are equally rapidly excreted in the urine.…”

Section: Introductionmentioning

confidence: 99%

The urinary excretion of selenium in sheep treated with a vasopressin analogue

et al. 2000

View full text Add to dashboard Cite

-The renal excretion of selenium was investigated in ewes with an excretion of hypotonic urine (control group) and in ewes with a formation of highly concentrated urine. Chronic stimulation of the urinary concentrating activity of sheep kidneys was induced by a long-term treatment with 1-desamino-8-D-arginine vasopressin (dDAVP), a synthetic analogue of vasopressin with prolonged effects. Young animals with 22 to 25 kg b.w. were fed a normal protein diet providing a daily intake of 129.25 g of crude protein, 12.03 MJ of digestible energy and 0.18 mg of selenium for 3 weeks. The vasopressin treated sheep (n = 11) were given subcutaneous injections of 12.5 µg of dDAVP in glycerol twice daily for one week before the clearance measurement of renal functions. The control group (n = 11) was treated with glycerol only. The administration of dDAVP resulted in a highly significant decrease of the urinary flow rate (from 3.19 ± 0.50 in control group to 0.33 ± 0.03 mL·min -1 in dDAVP animals, P < 0.001) without changes in the glomerular filtration rate (80.18 ± 6.36 in controls vs. 77.86 ± 6.26 mL·min -1 , NS). No effects on plasma selenium level were observed (0.17 ± 0.03 in controls vs. 0.20 ± 0.03 µmol·L -1 , NS) but the amounts of selenium excreted were found to be highly significantly reduced (from 0.29 ± 0.05 in controls to 0.03 ± 0.01 nmol·min -1 , P < 0.001) in dDAVP treated sheep. Despite a large reduction in urinary flow rate, the selenium concentration in urine was actually the same in both groups (0.09 ± 0.01 µmol·L -1 ) resulting in a sharp fall in the renal clearance of selenium (2.20 ± 0.54 in controls vs. 0.18 ± 0.03 mL·min -1 , P < 0.01) due to dDAVP. This seems to be a consequence of the large increase in the selenium solvent drag induced by a vasopressin treatment. The results presented suggest that vasopressin may contribute to maintenance of the selenium balance in sheep via its effects on renal function.sheep / kidney / renal function / vasopressin / selenium excretion Vet. Res. 31 (2000)

show abstract

Section: Introductionmentioning

confidence: 99%

The urinary excretion of selenium in sheep treated with a vasopressin analogue

et al. 2000

View full text Add to dashboard Cite

show abstract

“…2b), respectively. The renal partitioning of selenium could suggest that turtles coped with a metabolic excess of selenium enhancing its rate of glomerular filtration (Oster and Prellwitz 1990;Windisch 2002 The selenium levels were 22.1 ± ) over the course of the feeding trial in the target and non-destructive tissues collected from the SeMet 1 (a) and SeMet 2 (b) turtle groups. Black outlines target tissues, i.e.…”

Section: Selenium Kineticsmentioning

confidence: 99%

“…at T 5 , T 6 and T 7 ). The reported renal partitioning in the turtles could also indicate that the dietary selenium levels were not toxic for the turtles and even good for their metabolism (Oster and Prellwitz 1990). Indeed, adequate supplementation of selenium was indicated to enhance renal filtration and selenium accumulation (Oster and Prellwitz 1990).…”

Section: Selenium Kineticsmentioning

confidence: 99%

“…The reported renal partitioning in the turtles could also indicate that the dietary selenium levels were not toxic for the turtles and even good for their metabolism (Oster and Prellwitz 1990). Indeed, adequate supplementation of selenium was indicated to enhance renal filtration and selenium accumulation (Oster and Prellwitz 1990). That would be quite surprising considering that adverse effects were previously associated with similar dietary selenium levels in birds and lizards (Hoffman 2002;Rich and Talent 2009).…”

Section: Selenium Kineticsmentioning

confidence: 99%

See 1 more Smart Citation

Toxicokinetics of selenium in the slider turtle, Trachemys scripta

et al. 2016

View full text Add to dashboard Cite

Selenium (Se) is an essential element that can be harmful for wildlife. However, its toxicity in poikilothermic amniotes, including turtles, remains poorly investigated. The present study aims at identifying selenium toxicokinetics and toxicity in juvenile slider turtles (age: 7 months), Trachemys scripta, dietary exposed to selenium, as selenomethionine SeMet, for eight weeks. Nondestructive tissues (i.e. carapace, scutes, skin and blood) were further tested for their suitability to predict selenium levels in target tissues (i.e. kidney, liver and muscle) for conservation perspective. 130 juvenile yellow-bellied slider turtles were assigned in three groups of 42 individuals each (i.e. control, SeMet 1 and SeMet 2 ). These groups were subjected to a feeding trial including an eight-week supplementation period SP 8 and a following 4-week elimination period EP 4 . During the SP 8 , turtles fed on diet containing 1.1 ± 0.04, 22.1 ± 1.0 and 45.0 ± 2.0 lg g -1 of selenium (control, SeMet 1 and SeMet 2 , respectively). During the EP 4 , turtles fed on non-supplemented diet. At different time during the trial, six individuals per group were sacrificed and tissues collected (i.e. carapace, scutes, skin, blood, liver, kidney, muscle) for analyses. During the SP 8 (Fig. 1), both SeMet 1 and SeMet 2 turtles efficiently accumulated selenium from a SeMet dietary source. The more selenium was concentrated in the food, the more it was in the turtle body but the less it was removed from their tissues. Moreover, SeMet was found to be the more abundant selenium species in turtles' tissues. Body condition (i.e. growth in mass and size, feeding behaviour and activity) and survival of the SeMet 1 and SeMet 2 turtles seemed to be unaffected by the selenium exposure. There were clear evidences that reptilian species are differently affected by and sensitive to selenium exposure but the lack of any adverse effects was quite unexpected.

show abstract

“…Urinary selenium excretion also depends on the glomerular filtration of Se-compounds and on the concentrating/diluting function of the kidneys [13,14]. The finding of total selenium recovery from urine and faeces for both selenite and selenate (82-95%) in humans indicates that retention of Se of inorganic origin is very low, in contrast to selenomethionine with only 26% of the dose recovered [12].…”

Section: Introductionmentioning

confidence: 99%

Urinary selenium excretion in selenite-loaded sheep and subsequent Se dynamics in blood constituents

et al. 2003

View full text Add to dashboard Cite

-Renal selenium excretion in sheep was measured during intravenous infusion of sodium selenite, and the post-infusion dynamics of Se levels in whole blood, plasma and red blood cells (RBC) were investigated for the next 5 days. The plasma Se level increased almost twenty fold with the infusion of Na 2 SeO 3 (from 0.39 ± 0.02 to 7.83 ± 0.33 µmol·L -1 , P < 0.001) compared with the baseline value. The selenium concentration in urine (0.07 ± 0.02 vs. 18.53 ± 2.56 µmol·L -1 , P < 0.001), the amount of Se excreted (0.14 ± 0.07 vs. 21.40 ± 2.31 nmol·min -1 , P < 0.001) and the renal clearance of Se (0.19 ± 0.03 vs. 3.01 ± 0.34 mL·min -1 , P < 0.001) were found to be highly significantly elevated during selenite loading. The clearance measurements showed no changes in the urinary flow rate or in the glomerular filtration rate. During and at the end of infusion the highest Se level was attained in plasma, followed by whole blood and RBC. The plasma Se level fell rapidly within 10 min after the end of infusion, but the concentration of Se in RBC was stable up to the fourth hour, when it started to decrease too. On day 5 the Se concentrations in plasma, RBC and whole blood were found to be only slightly but still significantly higher than before the selenite infusion. The large disproportion between the infusion rate of Se (8.76 µg·min -1 ) and its renal excretion rate (1.69 µg·min -1 ) found in clearance measurements suggests low glomerular filtration of infused selenium, which might primarily be caused by the binding of selenite metabolites to blood constituents. The presented results confirm the low bioavailability to ruminants of Se from sodium selenite.sheep / sodium selenite / renal function / selenium excretion

show abstract

The renal excretion of selenium

Cited by 68 publications

References 50 publications

The urinary excretion of selenium in sheep treated with a vasopressin analogue

The urinary excretion of selenium in sheep treated with a vasopressin analogue

Toxicokinetics of selenium in the slider turtle, Trachemys scripta

Urinary selenium excretion in selenite-loaded sheep and subsequent Se dynamics in blood constituents

Contact Info

Product

Resources

About