The Renal Frontier in TAVR

Villablanca, Pedro A.; Ramakrishna, Harish

doi:10.1053/j.jvca.2017.02.030

Cited by 6 publications

(1 citation statement)

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“…Our findings underscore the urgent need for better strategies to prevent AKI and to improve the care of patients with AKI who do not recover or only partially recover their kidney function. Because AKI after TAVR is multifactorial and related to pre-, intra-, and postoperative factors (such as patients’ comorbidities, baseline renal function, and catheter-based techniques), a multidisciplinary approach with careful risk stratification of patients and multiple targeted interventions should be incorporated into potential strategies to prevent TAVR-related AKI [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

The association between renal recovery after acute kidney injury and long-term mortality after transcatheter aortic valve replacement

et al. 2017

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BackgroundThis study aimed to examine the association between renal recovery status at hospital discharge after acute kidney injury (AKI) and long-term mortality following transcatheter aortic valve replacement (TAVR).MethodsWe screened all adult patients who survived to hospital discharge after TAVR for aortic stenosis at a quaternary referral medical center from January 1, 2008, through June 30, 2014. An AKI was defined as an increase in serum creatinine level of 0.3 mg/dL or a relative increase of 50% from baseline. Renal outcome at the time of discharge was evaluated by comparing the discharge serum creatinine level to the baseline level. Complete renal recovery was defined as no AKI at discharge, whereas partial renal recovery was defined as AKI without a need for renal replacement therapy at discharge. No renal recovery was defined as a need for renal replacement therapy at discharge.ResultsThe study included 374 patients. Ninty-eight (26%) patients developed AKI during hospitalization: 55 (56%) had complete recovery; 39 (40%), partial recovery; and 4 (4%), no recovery. AKI development was significantly associated with increased risk of 2-year mortality (hazard ratio [HR], 2.20 [95% CI, 1.37–3.49]). For patients with AKI, the 2-year mortality rate for complete recovery was 34%; for partial recovery, 43%; and for no recovery, 75%; compared with 20% for patients without AKI (P < .001). In adjusted analysis, complete recovery (HR, 1.87 [95% CI, 1.03–3.23]); partial recovery (HR, 2.65 [95% CI, 1.40–4.71]) and no recovery (HR, 10.95 [95% CI, 2.59–31.49]) after AKI vs no AKI were significantly associated with increased risk of 2-year mortality.ConclusionThe mortality rate increased for all patients with AKI undergoing TAVR. A reverse correlation existed for progressively higher risk of death and the extent of AKI recovery.

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Section: Discussionmentioning

confidence: 99%