2002
DOI: 10.1046/j.1523-1755.2002.00479.x
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The renal segmental distribution of claudins changes with development

Abstract: The pattern of occludin distribution is present from the neonatal age. Claudins-7 and -8 are up-regulated after birth. Each tubular segment expresses a peculiar set of claudins that might be responsible for the permeability properties of their TJs.

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Cited by 153 publications
(139 citation statements)
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“…3). This staining pattern is in agreement with the findings of Reyes et al (22). Thyroid hormone treatment did not alter the staining pattern of claudin 2 in proximal tubules in neonate.…”
Section: Resultssupporting
confidence: 93%
“…3). This staining pattern is in agreement with the findings of Reyes et al (22). Thyroid hormone treatment did not alter the staining pattern of claudin 2 in proximal tubules in neonate.…”
Section: Resultssupporting
confidence: 93%
“…3 In fact, very few claudin mutations lead to abnormal renal physiology, in spite of the fact that most claudins are expressed within the adult nephron. 13,31,32 This strongly suggests that claudins may function in combination with other claudins to exert their effects on paracellular transport. There is evidence that claudins can both heteromerize and homomerize within tight junctions to influence paracellular transport, 33 but thus far a deeper understanding of how this influences cell and tissue function remains elusive.…”
Section: E964547-8mentioning
confidence: 99%
“…It is also clear that the patterns of claudin expression along the nephron changes with development, with CLDN-7 and -8 upregulated postnatally. 47 Figure 3. Schematic presentation of interaction possibilities between claudin molecules.…”
Section: The Renal Localization Of Claudinsmentioning
confidence: 99%