The renin-angiotensin-aldosterone system and catecholamines in chronic congestive heart failure. Effect of angiotensin I converting enzyme inhibitor SQ 14225 (captopril).

A clinical study on the role of the renin-angiotensin-aldosterone system and catecholamines in chronic congestive heart failure.

“…However, experimental studies in dogs with pulmonary stenosis and tricuspid insufficiency have shown a consistent rise in PRA and aldosterone secretion.29) There are only a few clinical reports on the relationship between the reninangiotensin-aldosterone system and hemodynamic parameters.16)- 18) In the present study, the mean PRA was found to be significantly higher in Class III-IV patients than in Class I-II patients, and it was correlated positively with SVR. These findings suggest that the renin-angiotensin system may contribute to the elevation of SVR to maintain effective arterial blood pressure in patients with severe heart failure.…”

Stability and Inter‐relationships of Hormone, Haemodynamic and Electrolyte Levels in Heart Failure in Man

“…Levels of angiotensin I1 (and renin) therefore might be taken to reflect the severity of both 'forward' and 'backward' failure of the left ventricle, as they appear to d o in experimental cardiac failure (Riegger & Liebau 1982). Whereas some workers likewise report associations between renin and haemodynamic indices in man (Kubo et al 1980;Dzau et al 1981;Hayduk et a/. 1980) others have failed to d o so (Kluger et al 1982;Levine et al 1982a, b;Brown et a/.…”

“…It is clear that the activity of a number of hormone systems is altered in patients with heart failure. The possibility that the magnitude of activation reflects severity of heart failure has been suggested by some workers (Thomas & Marks 1978;Kubo et al 1980;Kluger et al 1982;Levine et al 1982a). Further, it seems likely that by increasing the work of the failing left ventricle, such Correspondence: Dr M. G .…”