The renin-angiotensin-aldosterone system and hypertension in primary hyperparathyroidism

Ganguly, Arnab; Weinberger, Myron H.; Passmore, John M.; Caras, John; KHAIRI, RASHID M. A.; Grim, Clarence E.; Edmonson, J. B.; Johnston, C. Conrad

doi:10.1016/0026-0495(82)90098-1

Cited by 16 publications

(6 citation statements)

References 48 publications

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“…According to some authors, this prevalence may vary from 20 to 80%. [2][3][4][5] The results of our study confirm and extend these data reported in the 30,31 (c) renal function injury; 7,8 (d) activation of the renin-angiotension-aldosterone system; [32][33][34] (e) activation of the sympathetic nervous system; 26,29 (f) activation of the endothelin 35 and adrenomedullin 36 systems.…”

Section: Discussionsupporting

confidence: 83%

Ambulatory monitoring of blood pressure (AMBP) in patients with primary hyperparathyroidism

et al. 2005

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The purpose of our study was to evaluate the behaviour of blood pressure (BP) by ambulatory monitoring of blood pressure (AMBP) in 53 patients with primary hyperparathyroidism (PHPT) compared to 100 essential hypertensive (EH) and 31 healthy subjects (HS). The correlations between calcium-phosphorus metabolism and haemodynamic parameters in all groups are included in the study. AMBP was performed using the oscillometric technique (Space-Labs, 90207, Redmond, WA, USA) and the following AMBP parameters were evaluated: average day time systolic (S) and diastolic (D) blood pressure (BP) and heart rate (HR) (when awake), average night time SBP, DBP and HR (when asleep) and average 24-h-SBP, DBP and HR. The definition of 'dipper' or 'non-dipper' subjects was established if night time SBP and DBP fall was 410% and o10%, respectively. In total, 25 PHPT patients (47.2%) were hypertensive (HT-PHPT) and 28 PHPT (52.8%) were normotensive (NT-PHPT). Mean 24-h-SBP and DBP obtained by AMBP was higher in HT-PHPT (Po0.05) and EH (Po0.05) than in NT-PHPT and HS. The multiple linear regression has shown that in PHPT-HT patients ionized calcium is an independent factor for the rise of 24-h-DBP values (r: 0.497; Po0.05) and daytime DBP values (r: 0.497; Po0.05). In 56% of HT-PHPT patients there is an absence of physiological BP nocturnal fall ('non-dipper'), which is statistically significant (Po0.05) compared with 'nondipper' EH patients (30%). In conclusion, in our study the prevalence of hypertension in PHPT was 47%. AMBP revealed that the 'non-dipping 'pattern was much higher in HT-PHPT patients in respect to EH patients.

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Section: Discussionsupporting

confidence: 83%

Ambulatory monitoring of blood pressure (AMBP) in patients with primary hyperparathyroidism

et al. 2005

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“…1982). In agreement with other reports (Ganguly et al 1982), our hyperPTH patients had normal PRA and aldosterone levels, which did not change postoperatively. The role of calcium in modulating aldosterone response to its regulator angiotensin has also been studied in humans by testing aldosterone secretion during exogenous angiotensin II infusion at different calcemic levels.…”

Section: Discussionsupporting

confidence: 93%

“…Moreover, it has been suggested that hypercalcemia may have a direct vasoconstrictive action and/or mediate the release or the effect of vasoactive hormones (Pacifici, Perry, Shieber, Biglieri, Droke and Avioli 1987). A specific abnormality of the renin-angiotensin-aldosterone system or catecholamines has not been however identified in man with increased blood calcium levels due to exogenous administration (Fallo, Zangari, Luisetto, Ziliotto and Mantero 1987) or to primary hyperparathyroid function (Ganguly, Weinberger, Passmore, Caras, Khairi, Grim, Edmonson and Johnston 1982). Also, only limited information is available on the effect of changes in extracellular calcium on vascular and aldosterone responses to vasoactive agents (Bianchetti, Beretta-Piccoli, Weidmann, Boehringer, Link and Morton 1982;Brickman, Trujillo, Gutin and Tuck 1987).…”

Section: Introductionmentioning

confidence: 99%

Aldosterone and Pressor Responses to Angiotensin II in Primary Hyperparathyroidism

Fallo¹,

Rocco²,

Pagotto³

et al. 1989

Horm Metab Res

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“…There are no consistent changes in the renin-angiotensin system in hypertensives with primary hyperparathyroidism. 13,14 As a result, hypertension is not a definite but a relative indication for surgery in a patient with asymptomatic hypercalcemia whatever the age. 15 It is important not to promise hypertensive patients with primary hyperparathyroidism that their blood pressure will be returned to normal or improved following successful parathyroidectomy.…”

mentioning

confidence: 99%

Uncommon Forms of Secondary Hypertension in Older Patients

Dluhy

1998

American Journal of Hypertension

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The renin-angiotensin-aldosterone system and hypertension in primary hyperparathyroidism

Cited by 16 publications

References 48 publications

Ambulatory monitoring of blood pressure (AMBP) in patients with primary hyperparathyroidism

Ambulatory monitoring of blood pressure (AMBP) in patients with primary hyperparathyroidism

Aldosterone and Pressor Responses to Angiotensin II in Primary Hyperparathyroidism

Uncommon Forms of Secondary Hypertension in Older Patients

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