The renin-angiotensin-aldosterone system in congestive failure in conscious dogs.

Watkins, Lana L.; Burton, James; Haber, Edgar; Cant, J R; Smith, F. G.; Barger, A. C.

doi:10.1172/jci108431

Cited by 293 publications

(94 citation statements)

References 21 publications

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“…The dog with the greatest BP of 182/98 mmHg had the highest concentration of renin of 0.3113 nmol/L, whereas in the nonhunting group of dogs aged from 9 to 12 years hypertension was seen in 40%, which was related to the age of the dogs. Similar results were also reported by Watkins et al (13). The reason for this high BP probably lies in a disorder of the RAAS or kidney disease.…”

Section: Discussionsupporting

confidence: 90%

Comparison of the role of the renin-angiotensin aldosterone system in the genesis of hypertension between two groups of nonhunting dogs and hunting dogs

Jurida¹,

Ferizbegović²,

Krčmar³

2017

Turk J Vet Anim Sci

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The role of the renin-angiotensin aldosterone system in the genesis of hypertension between nonhunting dogs and hunting dogs of various breeds was comparatively studied in the city of Tuzla (Bosnia and Herzegovina). Sixty dogs were divided into four subgroups based on different age categories. Hypertension was recorded in 21 dogs or in 35% of examined dogs. Fourteen dogs had mild (23.3%), 5 dogs had moderate (8.3%), and 2 dogs had severe hypertension (3.3%). The most cases of hypertension (n = 9) were recorded in hunting dogs aged from 9 to 12 years. In subgroups of nonhunting and hunting dogs aged from 1 to 3 years, a high correlation was recorded between systolic and diastolic pressures (P < 0.0001). A certain degree of correlation was recorded between systolic pressure and renin (P = 0.037) and between heart rate and renin (P = 0.024). In subgroups of nonhunting and hunting dogs aged from 9 to 12 years, a high correlation was recorded between systolic and diastolic pressures (P = 0.006) and between diastolic pressure and heart rate (P = 0.002). A certain degree of correlation existed between systolic pressure and heart rate (P = 0.041), systolic pressure and aldosterone (P = 0.035), and heart rate and renin (P = 0.038). Increased values of renin were mostly recorded in dogs with hypertension. This research indicates the importance of routine blood pressure measurement during every examination, which can thus serve as a screening for undertaking further steps in processing the patient.

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Section: Discussionsupporting

confidence: 90%

Comparison of the role of the renin-angiotensin aldosterone system in the genesis of hypertension between two groups of nonhunting dogs and hunting dogs

Jurida¹,

Ferizbegović²,

Krčmar³

2017

Turk J Vet Anim Sci

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“…In relation to the values of serum aldosterone concentration, the results showed again a similarity between the groups and after the implementation of the treatment protocol, there was a significant reduction in values of animals receiving enalapril maleate, justified by the pharmacological action in the SRAA (Watkins et al 1976, Haggstrons et al 1996, Tidholm et al 2001. Furthermore, blood levels of aldosterone may increase with the clinical course of CHF so, in these cases, it might be used as a prognostic indicator for evolution and occurrence of sudden death in dogs with the studied heart disease (Ortega & Gomes 2007, O'Sullivan et al 2007.…”

Section: Discussionmentioning

confidence: 62%

Clinical evaluation of enalapril maleate and furosemide usage in dogs with degenerative myxomatous mitral valve, CHF functional class Ib

Franco¹,

Pereira²,

Camacho³

2011

Pesq. Vet. Bras.

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791Pesq. Vet. Bras. 31(9):791-797, setembro 2011 RESUMO.-[Avaliação clínica da utilização do maleato de enalapril e furosemida em cães com doença degenerativa mixomatosa da válvula mitral, classe funcional Ib.] A doença degenerativa mixomatosa da válvula mitral (DDMVM) é uma cardiopatia de alta incidência na clínica médica de pequenos animais, acometendo mormente cães idosos e raças de pequeno porte. Desta forma, foi realizada uma investigação científica objetivando avaliar clinicamente a utilização dos fármacos maleato de enalapril e furosemida em cães com a referida enfermidade na classe funcional Ib da ICC, antes e após a terapêutica implantada. Para isso, utilizaram-se 16 cães portadores da valvulopatia supracitada, distribuídos em dois grupos; com o primeiro recebendo furosemida (n=8) e o segundo maleato de enalapril (n=8), durante 56 dias. Os cães foram avaliados em quatro momentos (T0, T14, T28 e T56 dias) quanto aos sinais clínicos e parâmetros hematológicos e bioquímico-séricos, que incluíram concentrações séricas da enzima conversora da angiotensina (ECA) e aldosterona, como também avaliações radiográficas, eletrocardiográficas, ecodopplercardiográficas e da pressão arterial. Os resultados quanto aos parâmetros clínicos, avaliações hematológicas e bioquímicas séricas não revelaram alterações significativas em ambos os grupos, mas reduções significativas nos valores de ECA e aldosterona no grupo que recebeu o maleato de enalapril foram identificadas. Ao exame radiográfico obser- Degenerative myxomatous mitral valve (DMMV) is a heart disease of high incidence in small animal clinical medicine, affecting mainly older dogs and small breeds. Thus, a scientific investigation was performed in order to evaluate the clinical use of the medicines furosemide and enalapril maleate in dogs with this disease in CHF functional class Ib before and after the treatment was established. For this purpose 16 dogs with the given valve disease were used, separated into two groups: the first received furosemide (n=8) and the second received enalapril maleate (n=8) throughout 56 days. The dogs were evaluated in four stages (T0, T14, T28 and T56 day) in relation to clinical signs, hematological, biochemical and serum assessment, which included serum angiotensin converting enzyme (ACE) and aldosterone, as well as radiography, electrocardiography, Doppler-echocardiography and blood pressure. The results regarding the clinical, hematological and serum chemistry evaluations revealed no significant changes in both groups, but significant reductions in the values of ACE and aldosterone in the group receiving enalapril maleate were verified. The radiographic examination revealed reductions of VHS values and variable Pms wave of the electrocardiogram in both groups, but no changes in blood pressure values were identified. The echocardiogram showed a significant decrease of the variables LVDd/ s in the studied groups and the FS% in animals that received only enalapril. Therefore, analysis of results showed that monotherapy based on e...

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“…Stimulation of the renin-angiotensin system has been demonstrated in patients (Dzau et al, 1981;Packer et al, 1986) and in dogs (Watkins et al, 1976) with heart failure. This stimulation could be demonstrated by the increase of plasma renin activity which was correlated with the clinical status of the patients with heart failure (Dzau et al, 1981).…”

Section: Discussionmentioning

confidence: 99%

Effects of chronic heart failure on the responsiveness to angiotensin I and to angiotensin converting enzyme inhibition with cilazapril in rats.

Jp¹

1989

Brit J Clinical Pharma

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1. The effects of heart failure due to chronic myocardial infarction on the responsiveness to injected angiotensin I and ACE inhibition by intravenous cilazapril (1 mg kg‐1) were evaluated. 2. For this purpose one group of 17 rats with a 4‐week old myocardial infarction was compared with a group of 10 sham operated rats. 3. Heart failure increased markedly the responsiveness of the renal and mesenteric vascular beds to ACE inhibition which produced a vasodilation in these two vascular beds. 4. This increased responsiveness was most likely due to a stimulation of the renin‐angiotensin system without any change of sensitivity to angiotensin I of the renal and mesenteric vascular beds. 5. Cilazapril produced the same level of ACE inhibition in both groups of rats.

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The renin-angiotensin-aldosterone system in congestive failure in conscious dogs.

Cited by 293 publications

References 21 publications

Comparison of the role of the renin-angiotensin aldosterone system in the genesis of hypertension between two groups of nonhunting dogs and hunting dogs

Comparison of the role of the renin-angiotensin aldosterone system in the genesis of hypertension between two groups of nonhunting dogs and hunting dogs

Clinical evaluation of enalapril maleate and furosemide usage in dogs with degenerative myxomatous mitral valve, CHF functional class Ib

Effects of chronic heart failure on the responsiveness to angiotensin I and to angiotensin converting enzyme inhibition with cilazapril in rats.

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