The renin angiotensin system in childhood hypertension: Selective increase of angiotensin-(1-7) in essential hypertension

Silva, Ana Cristina Simões e; Diniz, José Silvério Santos; Filho, Ademar Regueira; Santos, Robson A.S.

doi:10.1016/j.jpeds.2004.03.055

Cited by 60 publications

(17 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…46 Simoes e Silva et al assessed the RAAS profiles in childhood hypertension (essential and renovascular) and the plasma renin activity reported for children with renovascular disease is comparable to our findings. 47 The plasma levels of Ang II in the present study are also comparable to controls and patients with essential hypertension, but lower than those with renovascular disease. 47 Additionally, plasma Ang-(1–7) levels are lower in the subjects in our study than all groups of children in the report by Simoes e Silva et al, 47 those of normotensive adults, 48 and a control group of young women.…”

Section: Discussionsupporting

confidence: 74%

“…47 The plasma levels of Ang II in the present study are also comparable to controls and patients with essential hypertension, but lower than those with renovascular disease. 47 Additionally, plasma Ang-(1–7) levels are lower in the subjects in our study than all groups of children in the report by Simoes e Silva et al, 47 those of normotensive adults, 48 and a control group of young women. 7 While there are differences in study populations and laboratory methods, when compared to these previous reports, the VLBW adolescents we studied had increased serum aldosterone, aldosterone-to-renin ratio, and plasma renin activity, and lower plasma Ang-(1–7).…”

Section: Discussionsupporting

confidence: 74%

See 1 more Smart Citation

The renin–angiotensin–aldosterone system in adolescent offspring born prematurely to mothers with preeclampsia

Washburn

Brosnihan²,

Chappell³

et al. 2014

J Renin Angiotensin Aldosterone Syst

View full text Add to dashboard Cite

Hypothesis/introduction Preeclampsia is associated with alterations in the maternal renin–angiotensin–aldosterone system (RAAS), increased blood pressure (BP), and cardiovascular risk in the offspring. We hypothesized that preeclampsia is associated with alterations in the RAAS in the offspring that persist into adolescence. Materials and methods We compared components of the circulating (n = 111) and renal (n = 160) RAAS in adolescents born prematurely with very low birth weight (VLBW) of preeclamptic (PreE) and normotensive (NoHTN) pregnancies. Multivariable linear regression was used to evaluate potential confounding and intermediate variables. Analyses were stratified by sex. Results Adjusting for race and antenatal steroid exposure, male offspring of PreE mothers had higher circulating aldosterone than those of NoHTN mothers (adjusted mean difference = 109; 95% confidence limits: −9, 227 pmol/L). Further adjustment for current BMI attenuated this difference (adjusted mean difference: 93; 95% confidence limits: −30, 215 pmol/L). Conclusion Among male preterm VLBW infants, maternal preeclampsia is associated with increased circulating aldosterone level in adolescence, which appears to be mediated in part by higher BMI.

show abstract

Section: Discussionsupporting

confidence: 74%

Section: Discussionsupporting

confidence: 74%

The renin–angiotensin–aldosterone system in adolescent offspring born prematurely to mothers with preeclampsia

Washburn

Brosnihan²,

Chappell³

et al. 2014

J Renin Angiotensin Aldosterone Syst

View full text Add to dashboard Cite

show abstract

“…The positive effect of Ang-(1-7) on steroidogenesis was inhibited by the specific MAS receptor antagonist A-779. In contrast, A-779 disrupted Ang II effect on progesterone, but not estradiol synthesis, suggesting that Ang II effect on progesterone may be a result of its conversion to Ang-(1-7) (Costa et al 2003, Simoes et al 2004.…”

Section: Angiotensin and Ovarian Folliclementioning

confidence: 84%

Role of angiotensin in ovarian follicular development and ovulation in mammals: a review of recent advances

Gonçalves¹,

Ferreira²,

Gasperin³

et al. 2012

Reproduction

View full text Add to dashboard Cite

Angiotensin (Ang) II is widely known for its role in the control of systemic blood vessels. Moreover, Ang II acts on the vascular control of ovarian function, corpus luteum formation, and luteolysis. Over the past 10 years, our research group has been studying the new concept of the renin-angiotensin system (RAS) as an autocrine/paracrine factor regulating steroidogenesis and promoting different cellular responses in the ovary, beyond vascular function. We have developed and used different in vivo and in vitro experimental models to study the role of RAS in the ovary and a brief overview of our findings is presented here. It is widely accepted that there are marked species differences in RAS function in follicle development. Examples of species-specific functions of the RAS in the ovary include the involvement of Ang II in the regulation of follicle atresia in rats vs the requirement of this peptide for the dominant follicle development and ovulation in rabbits and cattle. More recently, Ang-(1-7), its receptor, and enzymes for its synthesis (ACE2, NEP, and PEP) were identified in bovine follicles, implying that Ang-(1-7) has an ovarian function. Other novel RAS components (e.g. (pro)renin receptor and renin-binding protein) recently identified in the bovine ovary show that ovarian RAS is poorly understood and more complex than previously thought. In the present review, we have highlighted the progress toward understanding the paracrine and autocrine control of ovarian antral follicle development and ovulation by ovarian tissue RAS, focusing on in vivo studies using cattle as a model.

show abstract

“…Lower plasma Ang-(1-7) in patients with diabetes correlates with left ventricular dysfunction and with impaired endothelial-dependent vascular markers such as nitric oxide and prostacyclin [38,39]. In contrast, in younger children (average age <11 years) Ang-(1-7) is higher in patients with primary hypertension, suggesting potential compensation for elevated blood pressure at a younger age [40]. In the present study, individuals born preterm exhibited higher blood pressure and a higher rate of hypertension at 14 years of age, and both plasma and urinary Ang II:Ang-1-7 ratios correlated positively with blood pressure.…”

Section: Discussionmentioning

confidence: 99%

Association between preterm birth and the renin−angiotensin system in adolescence

South

Nixon

Chappell

et al. 2018

Journal of Hypertension

View full text Add to dashboard Cite

Objectives Preterm birth appears to contribute to early development of cardiovascular disease, but the mechanisms are unknown. Prematurity may result in programming events that alter the renin–angiotensin system. We hypothesized that prematurity is associated with lower angiotensin-(1-7) in adolescence and that sex and obesity modify this relationship. Methods We quantified angiotensin II and angiotensin-(1-7) in the plasma and urine of 175 adolescents born preterm and 51 term-born controls. We used generalized linear models to estimate the association between prematurity and the peptides, controlling for confounding factors and stratifying by sex and overweight/obesity. Results Prematurity was associated with lower plasma angiotensin II (β: −5.2 pmol/l, 95% CI: −10.3 to −0.04) and angiotensin-(1-7) (−5.2 pmol/l, 95% CI: −8.4 to −2.0) but overall higher angiotensin II:angiotensin-(1-7) (3.0 95% CI: 0.9–5.0). The preterm–term difference in plasma angiotensin-(1-7) was greater in women (−6.9 pmol/l, 95% CI: −10.7 to −3.1) and individuals with overweight/obesity (−8.0 pmol/l, 95% CI: −12.2 to −3.8). The preterm–term difference in angiotensin II:angiotensin-(1-7) was greater among those with overweight/obesity (4.4, 95% CI: 0.6–8.1). On multivariate analysis, prematurity was associated with lower urinary angiotensin II:angiotensin-(1-7; −0.13, 95% CI: −0.26 to −0.003), especially among the overweight/obesity group (−0.38, 95% CI: −0.72 to −0.04). Conclusion Circulating angiotensin-(1-7) was diminished whereas urinary angiotensin-(1-7) was increased relative to angiotensin II in adolescents born preterm, suggesting prematurity may increase the risk of cardiovascular disease by altering the renin–angiotensin system. Perinatal renin–angiotensin system programming was more pronounced in women and individuals with overweight/obesity, thus potentially augmenting their risk of developing early cardiovascular disease.

show abstract

The renin angiotensin system in childhood hypertension: Selective increase of angiotensin-(1-7) in essential hypertension

Cited by 60 publications

References 26 publications

The renin–angiotensin–aldosterone system in adolescent offspring born prematurely to mothers with preeclampsia

The renin–angiotensin–aldosterone system in adolescent offspring born prematurely to mothers with preeclampsia

Role of angiotensin in ovarian follicular development and ovulation in mammals: a review of recent advances

Association between preterm birth and the renin−angiotensin system in adolescence

Contact Info

Product

Resources

About