The renin–angiotensin system in adipose tissue and its metabolic consequences during obesity

Frigolet, María E.; Torres, Nimbe; Tovar, Armando R.

doi:10.1016/j.jnutbio.2013.07.002

Cited by 136 publications

(95 citation statements)

References 219 publications

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“…Adipose tissue exerts the largest source of extra hepatic circulating angiotensin, and adipose tissue-derived angiotensin has been suggested to be a factor contributing to the association between obesity and hypertension [24], with plasma levels of both angiotensinogen and angiotensin II showing positive correlations with BMI [42]. In our study, however, plasma angiotensin II levels are not altered with disease state.…”

contrasting

confidence: 62%

“…Adipose tissue exerts the largest source of extra hepatic circulating angiotensin [24], and here we found angiotensin pathways to be altered along with significant upregulation of AGT alongside, AGTR2 gene expression. We therefore investigated whether circulating levels of angiotensin II were altered.…”

Section: Circulating Angiotensin II Levelssupporting

confidence: 51%

“…Adipose tissue angiotensin has recently become recognized as a contributor to metabolic regulation [24]. The local adipose renin-angiotensin-system exerts important functions in modulating lipogenesis, lipolysis, adipogenesis as well as systemic and adipose tissue inflammation [36,37].…”

mentioning

confidence: 99%

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McCourt

Parker²,

Silajdžić

et al. 2015

JHD

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contrasting

confidence: 62%

Section: Circulating Angiotensin II Levelssupporting

confidence: 51%

See 1 more Smart Citation

Analysis of White Adipose Tissue Gene Expression Reveals CREB1 Pathway Altered in Huntington’s Disease

McCourt

Parker²,

Silajdžić

et al. 2015

JHD

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“…Local renin-angiotensin systems are widely distributed, and one is also present in adipocytes (for review see [56]). Additionally, substrates from isolated adipocytes may directly stimulate the secretion of aldosterone [57,58].…”

Section: Dysglycemia Dyslipidemia and Hypertensionmentioning

confidence: 99%

Metabolic Vascular Syndrome: New Insights into a Multidimensional Network of Risk Factors and Diseases

Scholz

Hanefeld

2016

Visc Med

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Background: Since 1981, we have used the term metabolic syndrome to describe an association of a dysregulation in lipid metabolism (high triglycerides, low high-density lipoprotein cholesterol, disturbed glucose homeostasis (enhanced fasting and/or prandial glucose), gout, and hypertension), with android obesity being based on a common soil (overnutrition, reduced physical activity, sociocultural factors, and genetic predisposition). We hypothesized that main traits of the syndrome occur early and are tightly connected with hyperinsulinemia/insulin resistance, procoagulation, and cardiovascular diseases. Methods: To establish a close link between the traits of the metabolic vascular syndrome, we focused our literature search on recent original work and comprehensive reviews dealing with the topics metabolic syndrome, visceral obesity, fatty liver, fat tissue inflammation, insulin resistance, atherogenic dyslipidemia, arterial hypertension, and type 2 diabetes mellitus. Results: Recent research supports the concept that the metabolic vascular syndrome is a multidimensional and interactive network of risk factors and diseases based on individual genetic susceptibility and epigenetic changes where metabolic dysregulation/metabolic inflexibility in different organs and vascular dysfunction are early interconnected. Conclusion: The metabolic vascular syndrome is not only a risk factor constellation but rather a life-long abnormality of a closely connected interactive cluster of developing diseases which escalate each other and should continuously attract the attention of every clinician.

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“…Согласно данной гипотезе, увеличение синтеза ангиотензиногена и ангиотензина II в адипоцитах способствует повышению концентрации этих белков в циркуляторном русле, что приводит к развитию гипертонии у человека. Более того, ангиотензин II, помимо влияния на сердечно-сосудистую систему и почки, вызывает инсулинорезистентность, нарушение толерантности к глюкозе, подавляет диффе-ренцировку адипоцитов, способствуя их гипертрофии, стимулирует липогенез и секрецию провоспалительных адипокинов адипоцитами (Frigolet et al, 2013), в резуль-тате чего развивается метаболический синдром. При этом активность РАС в жировой ткани не зависит от ак-тивности системной РАС: экспрессия ренина в жировой ткани не коррелирует с концентрацией этого фермента в крови (Marcus et al, 2013).…”

Section: моделирование патологий вавиловский журнал генетики и селекцunclassified

Renin-angiotensin-aldosterone system in ISIAH rats with stressinduced arterial hypertension

Dubinina¹,

Antonov²,

Fedoseeva³

et al. 2016

Vestn. VOGiS

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Because the renin-angiotensin system (RAS) has a wide range of opportunities in the regulation of fluid and electrolyte balance and arterial pressure, it is currently hypothesized that alterations in systemic circulating or local tissue RAS are some of the most important pathogenetic factors in the development of essential hypertension. The aim of the study was to investigate circulating and local tissue RAS activities in ISIAH rats with stress-induced arterial hypertension. We estimated the serum levels of renin, the angiotensin-convert ing enzyme, angiotensin II and aldosterone by an enzymelinked immunosorbent assay, and mRNA expression of RAS genes in kidney, adrenals and brain tissues was measured by the real-time polymerase chain reaction. The mRNA expression of the renin gene (Ren) in the ISIAH rats was significantly decreased as compared to the normotensive WAG rats, but plasma renin concentrations had no difference. At the same time, the serum levels of angiotensin II and aldosterone in the ISIAH rats were enhanced, which suggests the existence of an ectopic site of angiotensin synthesis. Expression of RAS genes in the adrenals of hypertensive rats was unchanged. By contrast, a significant increase of RAS genes expression was found in the brain tissues. The mRNA of the Ren gene was increased in the hypothalamus, and the mRNA of Ace gene was increased in the brain stem of the ISIAH rats. This may be indicative of a local increase of RAS activity in the brain tissues of ISIAH rats. Nevertheless, the results of the study define ISIAH rat strain as a model of human low-renin hypertension.Key words: ISIAH rat strain; renin-angiotensinaldosterone system; low-renin hypertension.Благодаря широкому спектру возможностей ренин-ангиотензи-новой системы (РАС) в регуляции водно-солевого баланса и арте-ри ального давления изменение ее активности на системном или локальном (тканевом) уровнях в настоящее время рассматривает-ся как один из наиболее значимых патогенетических факторов развития эссенциальной гипертонии. Цель работы -исследование циркуляторной и тканевой РАС у крыс НИСАГ со стресс-индуциро-ванной артериальной гипертензией. Была изме рена концентрация ренина, ангиотензин-превращающего фер мента, ангиотензина II и альдостерона в сыворотке крови методом иммуноферментного анализа, а также исследована экспрессия основных генов РАС в почке, надпочечнике и отделах мозга с помощью полимеразной цепной реакции в реальном времени. Обнаружено, что в почке крыс НИСАГ снижена экспрессия мРНК гена ренина Ren по сравне-нию с нормотензивными крысами WAG, при этом концентрация ренина в сыворотке крови крыс данных линий не отличается. В то же время у крыс этой гипертензив ной линии наблюдалось достоверное увеличение концентраций ангио тензина II и альдо-стерона в сыворотке крови, что может свидетельствовать о нали-чии «эктопического» очага синтеза ангиотензина II. В надпочечни-ках крыс НИСАГ экспрессия генов компонентов РАС не изменена. В структурах мозга показано уве личение экспрессии генов ком-понентов данной системы: Ren -в...

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The renin–angiotensin system in adipose tissue and its metabolic consequences during obesity

Cited by 136 publications

References 219 publications

Analysis of White Adipose Tissue Gene Expression Reveals CREB1 Pathway Altered in Huntington’s Disease

Analysis of White Adipose Tissue Gene Expression Reveals CREB1 Pathway Altered in Huntington’s Disease

Metabolic Vascular Syndrome: New Insights into a Multidimensional Network of Risk Factors and Diseases

Renin-angiotensin-aldosterone system in ISIAH rats with stressinduced arterial hypertension

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