The renoprotective effect of curcumin in cisplatin-induced nephrotoxicity

Ugur, Sıddık; Ulu, Ramazan; Doğukan, Ayhan; Gürel, Ali; Yigit, Irem Pembegul; Gözel, Nevzat; Aygen, Bilge; İlhan, Necip

doi:10.3109/0886022x.2014.986005

Cited by 93 publications

(68 citation statements)

References 38 publications

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“…Similar effects of curcumin on renal failure caused by cisplatin nephrotoxicity have been revealed in other studies. [17][18][19] In conclusion, the results of our study suggest that curcumin attenuates cisplatin-induced nephrotoxicity by preventing oxidative stress, inflammation, and apoptosis. Thus, we think that the results revealed in this study, for the first time, provides a basis for further research to discover the antiapoptotic effects of curcumin and contribute to the development of preventative treatment against cisplatin-induced nephrotoxicity.…”

Section: Discussionmentioning

confidence: 82%

“…Our findings are well matched with previous reports demonstrating similar effects of curcumin on renal damage induced by oxidative stress. 4,14,18,19 Inflammatory mechanisms are closely related to the pathogenesis of cisplatin-induced nephrotoxicity. In this study, we determined the increased renal MPO levels, a marker of inflammation, as a result of cisplatin exposure.…”

Section: Discussionmentioning

confidence: 99%

“…36,37 A recent study by Ugur et al demonstrated that increased MDA and decreased SIRT1 levels in cisplatin-mediated nephrotoxicity were improved with curcumin treatment. 18 In this study, we used curcumin in order to prevent cisplatin nephrotoxicity, because of its antioxidant and strong anti-inflammatory activity by inhibiting NF-Kb and proinflammatory cytokines. For the first time, we determined that curcumin prevented the development of renal tubular cell apoptosis (active caspase-3) by reducing the activation of proteins (Fas, Fas-L, and p53) involved in cisplatin-induced cell death.…”

Section: Discussionmentioning

confidence: 99%

“…11,12,15 It has been reported that curcumin prevents and ameliorates the severity of cisplatin nephrotoxicity, by inhibiting various cytokines and chemokines such as TNF-a and IL-1b and scavenging free radicals. 4,14,[17][18][19] However, there is no any study to support the antiapoptotic effect of curcumin in cisplatininduced nephrotoxicity, yet. Therefore, in this study, we evaluated the effects of curcumin on renal tubular cell apoptosis (the immunoreactivities of active caspase-3, Fas, Fas-L, and phospho-p53), in addition to inflammation [the levels of IL-1b, TNF-a, IL-6, IL-10, and myeloperoxidase (MPO)], lipid peroxidation [malondialdehyde (MDA)], and renal function (urea and creatinine levels) in cisplatin-mediated acute renal damage.…”

Section: Introductionmentioning

confidence: 99%

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Curcumin counteracts cisplatin-induced nephrotoxicity by preventing renal tubular cell apoptosis

2016

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Curcumin has several biological functions particularly antioxidant and anti-inflammatory. The aims of this study are determination of the protective effects of curcumin on cisplatin-induced renal tubular cell apoptosis and related pathways in kidney. Eighteen male Wistar albino rats were randomly divided into three groups (n ¼ 6): the control, cisplatin (CP), and cisplatin þ curcumin (CP þ CUR). Acute renal damage was induced by single dose of cisplatin (7.5 mg/ kg) injected by intraperitoneally (i.p). The animals of curcumin-treated group were received daily 200 mg/kg curcumin per os (po), starting from 2 days before the injection of cisplatin to the day of sacrifice. Forty-eight hours after cisplatin injection, samples of cardiac blood and kidneys were harvested from the animals. In this study, the major finding is that curcumin treatment ameliorates the following conditions associated with cisplatin-induced nephrotoxicity: (1) the development of kidney injury (histopathology), (2) inflammatory responses [myeloperoxidase (MPO) and tumor necrosis factor-alpha (TNF-a), interleukin-1 beta (IL-1b), IL-6, IL-10 levels], (3) the degree of lipid peroxidation [malondialdehyde (MDA) level], (4) renal tubular cell apoptosis (active caspase-3) and expression of related proteins [p53, Fas, and Fas ligand (Fas-L)] by immunohistochemistry, (5) renal dysfunction (serum urea and creatinine). In a conclusion, this study suggests that curcumin has antiapoptotic effect against cisplatin nephrotoxicity, in addition to anti-inflammatory and antioxidant properties. ARTICLE HISTORY

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Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Curcumin counteracts cisplatin-induced nephrotoxicity by preventing renal tubular cell apoptosis

2016

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“…Curcumin improves kidney function in animal models of AKI by effects that include activating NRF-2 and HO-1 (108,169,299). Experiments conducted by our laboratory and others demonstrated the renoprotective effects of resveratrol and ethyl pyruvate in various animal models (36,37,46,157,174,183,243,264).…”

Section: Naturally Occurring Antioxidantsmentioning

confidence: 90%

Oxidant Mechanisms in Renal Injury and Disease

Ratliff

Abdulmahdi

Pawar

et al. 2016

Antioxidants & Redox Signaling

556

513

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Significance: A common link between all forms of acute and chronic kidney injuries, regardless of species, is enhanced generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) during injury/ disease progression. While low levels of ROS and RNS are required for prosurvival signaling, cell proliferation and growth, and vasoreactivity regulation, an imbalance of ROS and RNS generation and elimination leads to inflammation, cell death, tissue damage, and disease/injury progression. Recent Advances: Many aspects of renal oxidative stress still require investigation, including clarification of the mechanisms which prompt ROS/ RNS generation and subsequent renal damage. However, we currently have a basic understanding of the major features of oxidative stress pathology and its link to kidney injury/disease, which this review summarizes. Critical Issues: The review summarizes the critical sources of oxidative stress in the kidney during injury/ disease, including generation of ROS and RNS from mitochondria, NADPH oxidase, and inducible nitric oxide synthase. The review next summarizes the renal antioxidant systems that protect against oxidative stress, including superoxide dismutase and catalase, the glutathione and thioredoxin systems, and others. Next, we describe how oxidative stress affects kidney function and promotes damage in every nephron segment, including the renal vessels, glomeruli, and tubules. Future Directions: Despite the limited success associated with the application of antioxidants for treatment of kidney injury/disease thus far, preventing the generation and accumulation of ROS and RNS provides an ideal target for potential therapeutic treatments. The review discusses the shortcomings of antioxidant treatments previously used and the potential promise of new ones.

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Efficacy of curcumin on prevention of drug‐induced nephrotoxicity: A review of animal studies

et al. 2019

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Drug‐induced nephrotoxicity is a frequent serious adverse effect, contributing to morbidity and increased healthcare utilization. Prevention or reversal is key. Curcumin has useful biological features that include antioxidant, anti‐inflammatory, and anticancer properties. This review covers aspects of curcumin in relation to prevention of drug‐induced nephrotoxicity: dosage and schedule, effect on kidney biomarkers and histological changes, and mechanisms of curcumin's protective effects. Despite success in some animal models, human studies and clinical administration of curcumin for nephroprotection remains limited due to difficulty in achieving therapeutic levels following oral administration and in determining the optimal dosing schedule. Lack of sufficient evidence from animal studies, coupled with low systemic bioavailability, continues to limit the utilization of curcumin in addressing and controlling drug‐induced nephrotoxicity. Therefore, human studies are required to fully assess and validate the therapeutic potential of curcumin.

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The renoprotective effect of curcumin in cisplatin-induced nephrotoxicity

Cited by 93 publications

References 38 publications

Curcumin counteracts cisplatin-induced nephrotoxicity by preventing renal tubular cell apoptosis

Curcumin counteracts cisplatin-induced nephrotoxicity by preventing renal tubular cell apoptosis

Oxidant Mechanisms in Renal Injury and Disease

Efficacy of curcumin on prevention of drug‐induced nephrotoxicity: A review of animal studies

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