The repeatability and validity of respiratory resistance measured by the forced oscillation technique

Neild, J.E.; Twort, C.H.C.; Chinn, Susan; McCormack, S.; Jones, Trevor; Burney, Peter; Cameron, I. R.

doi:10.1016/s0954-6111(89)80224-0

Cited by 32 publications

(29 citation statements)

References 17 publications

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“…The amount of artefactual data was low (4.9%) and the variability of unsupervised self-measurements (CV(Rrs)=7.9%) was similar to that reported in asthmatic adults from measurements performed by a technician in the lung function lab (ranging 4.9-10.3%) [16,17].…”

Section: Discussionsupporting

confidence: 69%

Unsupervised self-testing of airway obstruction by forced oscillation at the patient's home

Rigau

Burgos²,

García-Hernández³

et al. 2003

Eur Respir J

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As active patient cooperation is not required, the forced oscillation technique (FOT) could be suitable for measuring airway obstruction in routine home applications. Nevertheless, FOT has never been used at the patient9s home to date. The aim of this study was to assess the feasibility of FOT and the reproducibility of measured respiratory resistance (Rrs) in routine patient self-testing at home.Altogether, nine asthmatic patients self-measured their Rrs with a portable FOT device and spirometry for 10-14 days, in the morning and evening, and before and after bronchodilator inhalation. During each measurement session, the patients carried out four consecutive FOT measurements. Grubbs9 discordancy test for detecting outliers was used to evaluate intermeasure reliability.Only 4.9% of Rrs data reported by patients were rejected as artefacts. The coefficient of variation of Rrs was 7.9¡6.3% (mean¡SD). When compared with spirometry, the per cent change in Rrs for detecting a positive bronchodilator response showed an 83% sensitivity and 72% specificity.Unsupervised self-measurement of respiratory resistance at the patient9s home provided results similar to those obtained by a technician in a lung function lab. Forced oscillation technique could be a useful tool for the routine follow-up of asthmatic patients at home. Eur Respir J 2003; 22: 668-671.

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Section: Discussionsupporting

confidence: 69%

Unsupervised self-testing of airway obstruction by forced oscillation at the patient's home

Rigau

Burgos²,

García-Hernández³

et al. 2003

Eur Respir J

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“…A previous study in a small group (n=10) of grain workers showed similar outcome at 2 year follow-up [13]. Individual repeatability of R8 in our hands was slightly better compared to data published by NEILD et al [14] for impedance at 3 Hz (Z3Hz) (11.3%) or STANESCU et al [15] for resistance at 3-9 Hz (R3-9Hz) (12.0%) for short-term variability. Our coefficients of variation for R8 (10.5%), X8 (14.6%), and f0 (14.3%) would allow minimal detectable changes much smaller than those observed over 5 yrs in the present cohort.…”

Section: Discussionsupporting

confidence: 56%

A five year follow-up of lung function among chemical workers using flow-volume and impedance measurements

Keman¹,

Willemse²,

Wesseling³

et al. 1996

Eur Respir J

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A A f fi iv ve e y ye ea ar r f fo ol ll lo ow w--u up p o of f l lu un ng g f fu un nc ct ti io on n a am mo on ng g c ch he em mi ic ca al l w wo or rk ke er rs s u us si in ng g f fl lo ow w--v vo ol lu um me e a an nd d i im mp pe ed da an nc ce e m me ea as su ur re em me en nt ts s S. Keman*, B. Willemse*, G.J. Wesseling**, E. Kusters + , P.J.A. Borm* A five year follow-up of lung function among chemical workers using flow-volume and impedance measurements. S. Keman, B. Willemse, G.J. Wesseling, E. Kusters, P.J.A. Borm. ERS Journals Ltd 1996. ABSTRACT: Impedance of the respiratory system, measured using the forced oscillation technique (FOT), has repeatedly been proposed as a tool for occupational health screening.The aim of this study was to compare the outcome of impedance measurements and flow-volume curves, and to study relationships between lung function decline and specific exposures and smoking. Both measurements were applied in 136 chemical workers from seven main production/personnel groups during a 5 year followup (1990)(1991)(1992)(1993)(1994)(1995).The prevalence of airway obstruction (forced expiratory volume in one second (FEV1) <80% of predicted) at both time-points was about 5% but did not necessarily include the same subjects. The average decline in FEV1 over 5 yrs was 200 mL (predicted decline 160 mL). Although most impedance parameters correlated to flow-volume parameters in both years, a rapid 5 year decline of FEV1 (>330 mL) was only accompanied by a significant decrease in the reactance at 8 Hz (X8) and an increase in the resonance frequency (f0). Interestingly, decline in FEV1 was significantly dependent on age, years of employment, pack-years, FEV1, and all impedance parameters at the start in 1990 (r=0.35; p=0.01). Similarly, the increase in f0 was significantly dependent on age, years of employment, pack-years, f0, FEV1, forced vital capacity (FVC), peak expiratory flow (PEF) and maximal mid-expiratory flow (MMEF) at the start (r=0.56; p<0.01). Those with a rapid decline in FEV1 were relatively more represented among acid workers (relative risk (RR)=2.14), maintenance workers (RR=2.1) and bulk/transport workers (RR=1.78), but none of these was significant. Lung function, however, was significantly lower in the bulk/transport workers (n=14) compared to the rest, based both on flow-volume (FEV1, FVC) and impedance (X8, f0) measurements. Smoking had a significant effect on most flow-volume parameters but only for frequency dependence among the impedance outcomes.It is concluded that alterations in impedance parameters do reflect changes in flow-volume curves induced by age, smoking and occupational exposure. Therefore, these data are a valuable extension to current cross-sectional data. Eur Respir J., 1996Respir J., , 9, 2109 Although a decline in forced expiratory volume in one second (FEV1) is generally considered as a gold standard to detect airflow limitation, different (mechanical) alterations of the respiratory system can influence this parameter. Impedance measurements of ...

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“…We initially assessed the variability of spirometry, plethysmography and IOS. It is known that plethysmography is more variable than spirometry, and that FEV 1 is a less variable spirometric measurement compared with mid-expiratory flow rate readings such as MMEF [13,[17][18][19]. However, we could find only two previous studies comparing spirometry and plethysmography with oscillation techniques [13,14], which both showed that sGaw was the most variable test, followed by oscillometry, with spirometry the least variable.…”

Section: Discussionmentioning

confidence: 88%

A comparison of lung function methods for assessing dose–response effects of salbutamol

Houghton

Woodcock

Singh

2004

Brit J Clinical Pharma

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Pulmonary function methods which are able to detect small pharmacolog ical effects may be useful for assessing the full dose-response curve of bronchodilatators. We compared the ability of impulse oscillometry (R5, R20, X5, RF), plethysmography (sGaw) and spirometry [forced expiratory volume in 1 s (FEV 1 ), maximal mid expiratory flow rate (MMEF)] to measure the dose-response effects of salbutamol in 12 healthy subjects, 12 mild asthmatics (mean FEV 1 96% predicted) and 12 moderate asthmatics (mean FEV 1 63% predicted). The techniques were performed twice to assess variability. Then salbutamol 10, 20, 100, 200 and 800 m g was administered.The sensitivity of the methods were compared by determining the lowest dose that caused changes greater than variability. In healthy subjects significant changes ( p £ 0.05) were observed only in FEV 1 (4.1%) and MMEF (14.6%) at 100 m g and sGaw (25.6%) and R20 (8.3%) at 200 m g. In mild asthmatics significant changes were observed in sGaw (15.9%) at 10 m g, X5 (23%), RF (20.3%) and MMEF (15.7%) at 20 m g, R5 (13.9%) and R20 (9.4%) at 100 m g and FEV 1 (7.1%) at 200 m g. All measurements except R20 demonstrated significant changes at 10 m g in moderate asthmatics. The most sensitive test for assessing bronchodilatation is different in healthy subjects and asthmatics, and varies with severity of air flow obstruction.

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The repeatability and validity of respiratory resistance measured by the forced oscillation technique

Cited by 32 publications

References 17 publications

Unsupervised self-testing of airway obstruction by forced oscillation at the patient's home

Unsupervised self-testing of airway obstruction by forced oscillation at the patient's home

A five year follow-up of lung function among chemical workers using flow-volume and impedance measurements

A comparison of lung function methods for assessing dose–response effects of salbutamol

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