2024
DOI: 10.1101/2024.03.14.584947
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The replication properties of a contemporary Zika virus from West Africa depends on NS1/NS4B proteins

Dana Machmouchi,
Marie-Pierre Courageot,
Chaker El-Kalamouni
et al.

Abstract: Zika virus (ZIKV) have become a global health problem over the past decade due to the extension of the geographic distribution of ZIKV of Asian genotype. Epidemics of Asian ZIKV have been associated with developmental disorders in humans. ZIKV of African lineage would have an epidemic potential associated to fetal pathogenicity requiring a greater attention towards the most recently isolated viral strains from West Africa. In the present study, an infectious molecular clone GUINEA-18 has been obtained from vir… Show more

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Cited by 1 publication
(2 citation statements)
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“…After 5 days, P1 was recovered and amplified for a further 3 days to produce a working virus stock P2. Virus stock titers are determined by a standard plaque-forming assay as previously described (21,22,24). Infectious virus titers are expressed as plaque-forming units per ml (PFU.mL -1 ).…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…After 5 days, P1 was recovered and amplified for a further 3 days to produce a working virus stock P2. Virus stock titers are determined by a standard plaque-forming assay as previously described (21,22,24). Infectious virus titers are expressed as plaque-forming units per ml (PFU.mL -1 ).…”
Section: Methodsmentioning
confidence: 99%
“…Statistical analysis was noted (***P < 0.001, **P < 0.01, * P < 0.05). The replication efficiency of chimeric MR766 MC /NS1 CWA virus was next assessed in human epithelial A549 cells that have been chosen for their permissiveness to ZIKV infection (22,24) (Fig. 6).…”
Section: Replication Properties Of a Chimeric Mr766/ns1 Cwa Virusmentioning
confidence: 99%