The reproducibility and sensitivity of the 6-min walk test in elderly patients with chronic heart failure

Ingle, Lee; Shelton, Rhidian J.; Rigby, Alan S.; Nabb, Samantha; Clark, Andrew L.; Cleland, John G.F.

doi:10.1093/eurheartj/ehi259

Cited by 111 publications

(71 citation statements)

References 46 publications

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“…Ingle et al (32) demonstrated its satisfactory reproducibility when repeated in the followup; they also showed that changes in distance walked after 1 year correlated well with the modification in self-perceived symptoms. However, they collected no information on the cognitive level of their large study cohort, and therefore the influence of cognitive function on the reliability and validity of this test was not determined.…”

Section: Discussionmentioning

confidence: 95%

“…However, they collected no information on the cognitive level of their large study cohort, and therefore the influence of cognitive function on the reliability and validity of this test was not determined. In addition, the authors acknowledged the lack of measures of anxiety or depression as a study limitation, proposing that alterations in psychological and behavior profiles could affect the reliability of the test (32).…”

Section: Discussionmentioning

confidence: 99%

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Relationship between cognitive function and 6-minute walking test in older outpatients with chronic heart failure

et al. 2010

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Relationship between cognitive function and 6-minute walking test in older outpatients with chronic heart failure

et al. 2010

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“…6) In clinical cardiology, unfortunately, the test has been largely restricted to the evaluation of patients with chronic heart failure (CHF). [7][8][9][10] Although the American Thoracic Society guideline for the 6 MWT states that a "recent" (within a month) MI is an absolute contraindication for the test, 11) few data are available to support this contention. In fact, to the best of our knowledge, no previous study has looked at the safety, reliability, and repeatability of the 6 MWT in patients recovering from an acute MI.…”

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confidence: 99%

Clinical Reliability of the 6 Minute Corridor Walk Test Performed Within a Week of a Myocardial Infarction

et al. 2006

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SUMMARYThe 6 minute walk test (6 MWT) has been shown to provide a clinically useful index of functional capacity in chronic heart failure. We hypothesized that similar results would be found in patients who had a recent (ie, within a week) myocardial infarction (MI). Twenty-five patients (23 males, aged 43 to 72 years) who had undertaken an exercise stress test without complications underwent 3 consecutive 6 MWTs (1 hour apart). Heart rate, systolic and diastolic blood pressure, the level of perceived exertion (Borg scale), and the walking distance were determined. In addition, chest pain was assessed by a 0 to 10 numerical rating scale (NRS) and the ECG was continuously monitored. All subjects were able to successfully complete the exercise tests without major cardiovascular complications: mild chest pain (NRS 1 to 3) was found in 3 patients. A Bland-Altman analysis revealed that the mean bias ± 95% confidence interval of the differences on distance walked between test 2 -test 1 were substantially higher than test 3 -test 2 differences (18 ± 66 m and 6 ± 41 m, respectively). The intraclass correlation coefficients were consistently high for all physiological and sensorial responses at the end of the 6 MWTs (range, 0.75 to 0.95). The 6 MWT is a safe and reproducible measurement of functional capacity in stable patients after a noncomplicated MI, even when performed within a week of the event. Therefore, this test might be useful for the evaluation of exercise tolerance in phases I and II of inpatient cardiovascular rehabilitation programs or to assess functional responses to selected interventions. (Int Heart J 2006; 47: 533-540)

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“…(28) Additionally, treated patients were categorised in the < 300m bracket in the 6 min walking test, this test is strongly prognostic of subsequent mortality and hospital admission in stable chronic HF (29,30) and in patients with advanced HF. (31,32) Improvement of >100m was demonstrated in treated patients, (improvement of >50 m has been reported as clinically very meaningful, (33) while decreases in walking distance were found in control patients. New York Heart Association (NYHA) index was shown to decrease from a mean of 2.9 in treated patients to 1.96 over six has progressed through pre-clinical studies, (20,21,34) and is currently waiting to start phase I clinical trials (NCT02305602).…”

Section: Acellular Materials Based Scaffoldsmentioning

confidence: 92%

Biomaterial‐Enhanced Cell and Drug Delivery: Lessons Learned in the Cardiac Field and Future Perspectives

et al. 2016

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Heart failure is a significant clinical issue. It is the cause of enormous healthcare costs worldwide and results in significant morbidity and mortality. Cardiac regenerative therapy has progressed considerably from clinical and preclinical studies delivering simple suspensions of cells, macromolecule, and small molecules to more advanced delivery methods utilizing biomaterial scaffolds as depots for localized targeted delivery to the damaged and ischemic myocardium. Here, regenerative strategies for cardiac tissue engineering with a focus on advanced delivery strategies and the use of multimodal therapeutic strategies are reviewed.

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The reproducibility and sensitivity of the 6-min walk test in elderly patients with chronic heart failure

Abstract: In elderly patients with CHF, the 6-MWT shows satisfactory agreement when repeated 1 year later. Change in 6-MWT distance is sensitive to change in self-perceived symptoms of heart failure.

Cited by 111 publications

References 46 publications

Relationship between cognitive function and 6-minute walking test in older outpatients with chronic heart failure

Relationship between cognitive function and 6-minute walking test in older outpatients with chronic heart failure

Clinical Reliability of the 6 Minute Corridor Walk Test Performed Within a Week of a Myocardial Infarction

Biomaterial‐Enhanced Cell and Drug Delivery: Lessons Learned in the Cardiac Field and Future Perspectives

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