The reproductive functions of the human brain regions: A systematic review

The long-established link between nutrition and reproduction is known to have critical consequences for reproductive function. However, the availability of experimental data on effect of folate deficiency on ovarian health is scarce and uncertain. Our objective was to establish a proof for association between folate deficiency, hormone dynamics, and health of the ovary through in vivo model organism. Folate-deprived female zebrafishes were developed using intraperitoneal administration of methotrexate (MTX) and they were used to study the possible implications of folate deprivation on ovarian health. Changes in the expression of transcripts regulating appetite and ovarian function was assessed by qRT-PCR. ELISA based methods were utilised to quantify and evaluate changes in hormone levels regulating reproductive function. Histology of ovarian tissue was performed to support the study. Folate deprivation resulted in impaired appetite behaviour and alters its regulatory gene expression. Due to folate deficiency, the neuroendocrine function of the brain was affected that resulted in altered reproductive hormone levels. Histological parameter of ovary was performed wherein the follicles are arrested in primary oocyte stage and abundance of scarring of tissue is seen. Furthermore, elevated lipid peroxidation and catalase enzyme activity indicates folate deficiency induced oxidative stress in ovary as one of the responsible mechanisms to aide ovarian dysfunction. Our study provides experiment proof with in vivo folate deficient model of fish that suggests B9 non-availability resulted into loss of appetite and, female gonadal dysfunction, which developed as cumulative effect of deficiency and altered appetite. The intricate interplay between folate deficiency and appetite along with the consequential implications for the synthesis and release of female reproductive hormones, warrant a thorough and in-depth exploration through further research.

show abstract

Influence of certain temperamental traits on the level of sex hormones in blood plasma of female Bull Terriers

Forkun,

Bobrytska,

Vodopianova

et al. 2023

J. Vet. Med. Biotechnol. Biosafety

View full text Add to dashboard Cite

To evaluate the influence of certain temperamental characteristics on the level of sex hormones in the blood plasma of female Bull Terriers, an experiment was conducted with 15 female Bull Terriers. Pregnancy screening was performed on 21st–28th days after ovulation). The material for the study were blood plasma samples of bitches obtained at different stages of the sexual cycle, in which the levels of estradiol, follicle stimulating hormone, luteinizing hormone, and progesterone were measured. The assessment of temperamental traits was performed at the design stage of the experiment using the standardized C BARQ methodology. One-way analysis of variance was used to determine the strength of the influence of individual temperament traits on the level of sex hormones in the blood plasma of bitches. According to the results of the experiment, it was found that the degree of fear and anxiety in bitches significantly affects the content of follicle-stimulating hormone, estradiol, and luteinizing hormone in the blood plasma of bitches three days before, during and 120–150 days after the LH surge (ղ²ᵪ = 0.27–0.55 (P ≤ 0.05). The excitability of bitches affects the level of follicle stimulating hormone, luteinizing hormone, and progesterone on the day of the LH surge — ղ²ᵪ = 0.32 (P ≤ 0.05). In addition, the level of excitability affects the level of progesterone on the 9th day after the surge — ղ²ᵪ = 0.35 (P ≤ 0.05) and the level of luteinizing hormone on the 2nd, 4th, 55th–60th days and after the LH surge — ղ²ᵪ = 0.26–0.43 (P ≤ 0.05). The degree of aggression affects the luteinizing hormone level two days after the surge and the progesterone level on 55th–60th days after the LH surge (ղ²ᵪ = 0.34–0.36; P ≤ 0.05). Training ability and obedience affect follicle stimulating hormone levels (the day before the surge, and on 4th, 9th, and 35th–40th days after the LH surge (ղ²ᵪ = 0.30–0.52; P ≤ 0.05), luteinizing hormone (on 9th day after LH surge, ղ²ᵪ = 0.54; P ≤ 0.01), and progesterone (on 35th–40th days after LH surge, ղ²ᵪ = 0.34; P ≤ 0.05)

show abstract

The reproductive functions of the human brain regions: A systematic review

Cited by 4 publications

References 51 publications

The role of the brain in human reproduction: a region-based evidence review

The role of the brain in human reproduction: a region-based evidence review

Folate deficiency links impaired appetite routing to ovarian dysfunction

Influence of certain temperamental traits on the level of sex hormones in blood plasma of female Bull Terriers

Contact Info

Product

Resources

About