The research of human exposure to polybrominated diphenyl ethers and perfluoroocatane sulfonate

Wang, Yawei; Jiang, Guibin

doi:10.1007/s11434-008-0122-y

Cited by 11 publications

(2 citation statements)

References 89 publications

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“…For humans, although serum concentrations of PFOS and PreFOS have declined in the U.S. since the phase out, PFOS concentrations in some Chinese populations have been increasing, , and the relative role of PFOS and PreFOS is unknown. Knowing the human exposure sources in all areas of the world would more effectively facilitate exposure mitigation steps.…”

Section: Introductionmentioning

confidence: 99%

Enantiomer Fractions of Chiral Perfluorooctanesulfonate (PFOS) in Human Sera

Wang

Beesoon

Benskin

et al. 2011

Environ. Sci. Technol.

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Perfluorooctane sulfonate (PFOS) is the most prominent perfluoroalkyl contaminant in humans and wildlife, but there is great uncertainty in exposure pathways, particularly with respect to the importance of PFOS-precursors (PreFOS). We explored the hypothesis that nonracemic proportions of chiral PFOS in serum are qualitative and semiquantitative biomarkers of human PreFOS exposure. A new chiral HPLC-MS/MS method was developed for alpha-perfluoromethyl branched PFOS (1m-PFOS, typically 2-3% of total PFOS) and applied to enantiomer fraction (EF) analysis in biological samples. In blood and tissues of rodents exposed subchronically to electrochemical PFOS, 1m-PFOS was racemic (EF = 0.485-0.511) and no evidence for enantioselective excretion was found in this model mammal. 1m-PFOS in serum of pregnant women, from Edmonton, was significantly nonracemic, with a mean EF (±standard deviation) of 0.432 ± 0.009, similar to pooled North American serum. In a highly exposed Edmonton family (mother, father, and 5 children) living in a house where ScotchGard had been applied repeatedly to carpet and upholstery, EFs ranged from 0.35 to 0.43, significantly more nonracemic than in pregnant women. Semiquantitative estimates of % serum 1m-PFOS coming from 1m-PreFOS biotransformation in both subpopulations were in reasonable agreement with model predictions of human exposure to PFOS from PreFOS. The data were overall suggestive that the measured nonracemic EFs were influenced by the relative extent of exposure to PreFOS. The possibility of using 1m-PFOS EFs for assessing the relative contribution of 1m-PreFOS (or PreFOS in general) in biological samples requires further application before being fully validated, but could be a powerful tool for probing general sources of PFOS in environments where the importance of PreFOS is unknown.

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Section: Introductionmentioning

confidence: 99%

Enantiomer Fractions of Chiral Perfluorooctanesulfonate (PFOS) in Human Sera

Wang

Beesoon

Benskin

et al. 2011

Environ. Sci. Technol.

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“…9,19) 현재는 기존 SPE법에 흑연화 탄소 흡착제인 Envi-carb를 첨가하여 방해물질을 제거하는 방법이 널리 사용되고 있다. 20,23,27) 마 지막으로 IPE법과 SPE법을 결합한 IPE + SPE법은 다른 방 법들에 비해 비교적 최근에 보고되어 보편화되어 있진 않지 만 IPE법의 높은 추출효율과 SPE법의 방해물질 정제효과를 결합한 분석법이다 28,29).…”

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Monitoring and Development of Pretreatment Method for Perfluorinated Compounds in Fish Samples

Heo¹,

Lee²,

Kim³

et al. 2013

Journal of Korean Society of Environmental Engineers

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An efficient extraction method was developed for the analysis of 16 perfluorinated compounds (PFCs) in fish samples. We compared the recoveries from the Ion-Pairing Extraction (IPE), Liquid-Liquid Extraction (LLE), Solid-Phase Extraction (SPE), IPE + SPE method with varying the injection time of the internal standard. As a result, IPE method with the internal standard before extraction was evaluated as the most effective pretreatment method. The RPM (Revolution Per Munite) and pH in IPE-before method were additionally adjusted and the more efficient pretreatment method was established. The total 33 fish samples including liver and gut samples were collected from Korean markets and analyzed PFCs with developed pretreatment method of this study. Total 16 PFC levels in fish samples ranged from ND to 1.67 ng/g with 100% detection frequency. The average PFCs concentrations of muscle, liver and gut samples from fish were compared and showed the following trend: liver (17.8 ng/g) > gut (13.3 ng/g) > muscle (1.67 ng/g). The PFC levels in fish samples were similar or lower than other available previous results of foreign studies.

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