Analyzing the influence of the spatial spillover effect of college students’ Entrepreneurial Activeness Degree (EAD) in each region on the cultivation intensity of their Innovation and Entrepreneurial Ability (IEA) is of certain theoretical and practical significance. However, in the research of domestic scholars, when studying the relationship between the EAD of college students and the cultivation intensity of their IEA, they generally give comprehensive evaluations based on the Evaluation Index Systems (EISs) they built, few of them have concerned about the spatial spillover effect of the EAD of college students, and relevant analysis based on spatial measurement method is rarely seen. To fill in this research blank, this paper aims to study the spatial spillover effect of the EAD of college students based on the improvement of IEA. At first, the paper gave the analysis framework of EAD, and adopted a layer-by-layer vertical and horizontal scatter degree method to perform dynamic measurement on the EAD of college students based on evaluation data collected from different regions. Then, this paper built a college student innovation and entrepreneurial Knowledge Production Function (KPF) model and used it to analyze the relationship between IEA cultivation intensity and the EAD of college students, thereby attaining the development status and spatial spillovers of the entrepreneurial activities of college students. At last, experimental results proved the effectiveness of the measurement method and the constructed model, and the analysis results of the spatial spillover effect in the study regions were given.