The star tracker is widely used for high-accuracy missions due to its high accuracy position high autonomy and low power consumption. On the other hand, the ability of interference suppression of the star tracker has always been a hot issue of concern. A SLIC-DBSCAN-based algorithm for extracting effective information from a single image with strong interference has been developed in this paper to remove interferences. Firstly, the restricted LC (luminance-based contrast) transformation is utilized to enhance the contrast between background noise and the large-area interference. Then, SLIC (the simple linear iterative clustering) algorithm is adopted to segment the saliency map and in this process, optimized parameters are harnessed. Finally, from these segments, features are extracted and superpixels with similar features are combined by using DBSCAN (density-based spatial clustering of applications with noise). The proposed algorithm is proved effective by successfully removing large-area interference and extracting star spots from the sky region of the real star image.