The research progress in the interaction between Candida albicans and cancers

Yu, Dalang; Liu, Zhiping

doi:10.3389/fmicb.2022.988734

Cited by 20 publications

(16 citation statements)

References 96 publications

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“…In addition, its abundance in the fecal samples of patients with advanced CRC was lower than in the fecal samples obtained from patients with early disease, i.e., the abundance of Butyricicoccus decreased gradually as CRC progressed, this differs from the experimental results of this study. In terms of fungi, the beneficial or harmful effects of Candida have to be analyzed on a case-by-case basis, for example, Candida _ versatilis and Candida_sp_JCM_15000 are mainly found in healthy populations ( 46 ), whereas Candida albicans is an opportunistic pathogen that can promote the development of CRC ( 47 ). In general, our results illustrate that Fn and its metabolite H 2 S promote CRC by increasing the abundance of harmful bacteria and fungi as well as decreasing the abundance of beneficial bacteria and fungi.…”

Section: Discussionmentioning

confidence: 99%

Fusobacterium nucleatum and its metabolite hydrogen sulfide alter gut microbiota composition and autophagy process and promote colorectal cancer progression

Wang,

Lessing

et al. 2023

Microbiol Spectr

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Fusobacterium nucleatum is a harmful bacterium that produces hydrogen sulfide by metabolizing sulfur-containing amino acids, both of which have been shown to promote/initiate the development of various cancers, such as colorectal cancer, liver cancer, as well as lung cancer. However, few studies have reported how F. nucleatum acts on gut microbiota, influences the autophagy process, and promotes the development of colorectal cancer through the metabolite hydrogen sulfide. It was found that HCT116 cells secreted more inflammatory factors and showed higher survival as well as migration rate when given a pathological concentration of hydrogen sulfide. Using cellular transcriptome sequencing, it could be seen that after giving HCT116 cells F. nucleatum or F. nucleatum with L-cysteine, many inflammation-related signaling pathways, including autophagic pathways, were elevated compared to the control group. In vivo , the mice in the model groups displayed cancer progression, and the expression of some of the autophagy-related genes, DRAM1 , NBR1 , ATG7 , MAP1LC3A were also increased in mice given F. nucleatum or F. nucleatum with L-cysteine when compared to the untreated control mice. The number of certain probiotic bacteria and fungi in the mice given F. nucleatum or F. nucleatum and L-cysteine decreased significantly; in contrast, the number of potentially pathogenic bacteria and fungi increased. These findings suggest that F. nucleatum and its metabolite hydrogen sulfide can modulate intestinal microbiota and autophagy as well as promote the development and progression of colorectal cancer. IMPORTANCE Colorectal cancer (CRC) is the second most common cancer in the world; the main treatment for CRC is immunosuppressive therapy, but this therapy is only effective for a small percentage of CRC patients, so there is an urgent need for a treatment with fewer side effects and higher efficacy. This study demonstrated that Fusobacterium nucleatum with increased abundance in CRC can regulate the autophagy process and disrupt normal intestinal microbiota by producing hydrogen sulfide, factors that may be involved in the development and progression of CRC. This study may provide a reference for future CRC treatment options that are efficient and have fewer side effects.

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Section: Discussionmentioning

confidence: 99%

Fusobacterium nucleatum and its metabolite hydrogen sulfide alter gut microbiota composition and autophagy process and promote colorectal cancer progression

Wang,

Lessing

et al. 2023

Microbiol Spectr

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“…After the integrity of the epithelial cells has been damaged, induced endocytosis occurs, followed by active infiltration, which is considered a pivotal step in pathogenesis [7,35]. The fungus's weakening of the host's defense mechanisms during colonization and invasion and the subsequent structural changes are linked with an increased risk of cancer development [19,20]. Moreover, the invasive enzymes possessed by C. albicans are of exceptional importance in the pathogenesis process, enabling it to destroy the integrity of the mucosal tissue structure and thereby contribute to the virulence of the strain and further impact on the cells [7].…”

Section: Skin Cancermentioning

confidence: 99%

“…loss of E-cadherin and occluding observed in epithelial-mesenchymal transition (EMT) [55] 3. activation of angiogenesis and proangiogenic factors [65] 4. enhanced production of known carcinogenic molecules such as nitrosamines and acetaldehyde [19,47]…”

Section: Skin Cancermentioning

confidence: 99%

“…However, recent research shows that C. albicans may actually prompt cancer development through multiple mechanisms, such as inducing inflammation, inducing Th17 (helper T cells) responses, producing carcinogenic byproducts, and using molecular mimicry [ 18 ] ( Table 2 ). As a result, these mechanisms collectively increase the host’s susceptibility to cancer, such as oral, stomach, colorectal, and other cancers [ 19 ].…”

Section: Exploring the Links Between Candida Albicans ...mentioning

confidence: 99%

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A Putative Role of Candida albicans in Promoting Cancer Development: A Current State of Evidence and Proposed Mechanisms

et al. 2023

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Candida albicans is a commensal fungal species that commonly colonizes the human body, but it is also a pervasive opportunistic pathogen in patients with malignant diseases. A growing body of evidence suggests that this fungus is not only coincidental in oncology patients, but may also play an active role in the development of cancer. More specifically, several studies have investigated the potential association between C. albicans and various types of cancer, including oral, esophageal, and colorectal cancer, with a possible role of this species in skin cancer as well. The proposed mechanisms include the production of carcinogenic metabolites, modulation of the immune response, changes in cell morphology, microbiome alterations, biofilm production, the activation of oncogenic signaling pathways, and the induction of chronic inflammation. These mechanisms may act together or independently to promote cancer development. Although more research is needed to fully grasp the potential role of C. albicans in carcinogenesis, the available evidence suggests that this species may be an active contributor and underscores the importance of considering the impact of the human microbiome on cancer pathogenesis. In this narrative review, we aimed to summarize the current state of evidence and offer some insights into proposed mechanisms.

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“…3,4 The increasing number of immunocompromised individuals, including cancer patients, organ transplant recipients, individuals infected with HIV, patients with diabetes and chronic obstructive pulmonary diseases, and the increasing elderly population has resulted in a surge in diseases caused by fungi in recent decades. [5][6][7][8] The extensive and repeated use of the existing classes of antifungal drugs resulted in the resistance of fungal strains to available drug therapies. [9][10][11][12][13] In addition, Candida auris, first identified in 2009 in Asia, has quickly become a cause of severe recalcitrant infections and deaths around the world.…”

Section: Introductionmentioning

confidence: 99%

Discovery and development of novel substituted monohydrazides as potent antifungal agents

et al. 2023

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The research progress in the interaction between Candida albicans and cancers

Cited by 20 publications

References 96 publications

Fusobacterium nucleatum and its metabolite hydrogen sulfide alter gut microbiota composition and autophagy process and promote colorectal cancer progression

Fusobacterium nucleatum and its metabolite hydrogen sulfide alter gut microbiota composition and autophagy process and promote colorectal cancer progression

A Putative Role of Candida albicans in Promoting Cancer Development: A Current State of Evidence and Proposed Mechanisms

Discovery and development of novel substituted monohydrazides as potent antifungal agents

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