The resilient brain: psychological resilience mediates the effect of amplitude of low-frequency fluctuations in orbitofrontal cortex on subjective well-being in young healthy adults

Kong, Feng; Ma, Xiaosi; You, Xuqun; Xiang, Yanhui

doi:10.1093/scan/nsy045

Cited by 69 publications

(56 citation statements)

References 91 publications

(137 reference statements)

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“…The SFG is generally considered a core brain region in the cognitive control system (Niendam et al, 2012) and for emotion regulation-related processes (Frank et al, 2014), which are hypothesized to be crucial for perceived stress that emphasizes the subjective cognitive and emotional adjustment for objective stressors (Cohen et al, 1983;Phillips, 2012). Additionally, the positive association of the fALFF in the left SFG with perceived stress may reflect a compensatory mechanism to counteract functional or structural brain abnormalities (Bing et al, 2013;Kong et al, 2018;Orr et al, 2013;Wang, Zhao, et al, 2018), which might be linked to the outcomes or difficulties induced by higher levels of perceived stress.…”

Section: Discussionmentioning

confidence: 99%

Stress and the brain: Perceived stress mediates the impact of the superior frontal gyrus spontaneous activity on depressive symptoms in late adolescence

Wang

Zhao

Zhang

et al. 2019

Human Brain Mapping

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Identifying factors for the prediction of depression is a long‐standing research topic in psychiatry and psychology. Perceived stress, which reflects the tendency to appraise one's life situations as stressful and overwhelming, has emerged as a stable predictor for depressive symptoms. However, the neurobiological bases of perceived stress and how perceived stress influences depressive symptoms in the healthy brain remain largely unknown. Here, we investigated these issues in 217 healthy adolescents by estimating the fractional amplitude of low‐frequency fluctuations (fALFFs) via resting‐state functional magnetic resonance imaging. A whole‐brain correlation analysis showed that higher levels of perceived stress were associated with greater fALFF in the left superior frontal gyrus (SFG), which is a core brain region for cognitive control and emotion regulation‐related processes. Mediation analysis further indicated that perceived stress mediated the link between the fALFF in the left SFG and depressive symptoms. Importantly, our results remained significant even when excluding the influences of head motion, anxiety, SFG gray matter structure, and school environment. Altogether, our findings suggested that the fALFF in the left SFG is a neurofunctional marker of perceived stress in adolescents and revealed a potential indirect effect of perceived stress on the association between the SFG spontaneous activity and depressive symptoms.

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Section: Discussionmentioning

confidence: 99%

Stress and the brain: Perceived stress mediates the impact of the superior frontal gyrus spontaneous activity on depressive symptoms in late adolescence

Wang

Zhao

Zhang

et al. 2019

Human Brain Mapping

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“…If the OFC and precuneus became more strongly connected, conservatives were more likely to be resilient to psychological stress and have greater self-regulation capacity, specifically impulse control and causal reasoning. The OFC is one of key regions involved in self-regulation and psychological resilience, while the precuneus processes emotion regulation as coactivated with the amygdala 24,41,42 . The connectivity between these regions is related to the self-processing of negative emotional distractors and mental representation 29 .…”

Section: Scientific Reportsmentioning

confidence: 99%

“…We cleaned noise signals by conducting nuisance regression using a component-based noise correction method (CompCor), linear detrending, and temporal bandpass filtering (0.008 < f < 0.09 Hz) 69,70 . functional connectivity analysis. To investigate seed-based functional connectivities, we selected the regions of interest (ROIs) according to previous neuroimaging studies reporting brain function in self-regulation and psychological resilience as follows: the ACC, amygdala, insula, and OFC 10,14,24,39 . The ROIs were defined using the Harvard-Oxford cortical and subcortical atlases.…”

Section: Participantsmentioning

confidence: 99%

“…However, the neural underpinnings of the aforementioned psychological buffers need to be studied to expand our understanding of the mental responses of liberals and conservatives to stressful issues. Because psychological resilience and self-regulation are complex processes, the neural underpinnings may not be fully understood by investigations of limited brain regions under certain task conditions 24 . Intrinsic brain organization analysis is an alternative approach to examine how multiple regions communicate with each other without limiting the analysis to a specified task condition 25 .…”

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confidence: 99%

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Intrinsic functional connectivity of blue and red brains: neurobiological evidence of different stress resilience between political attitudes

Kim

Hur

Kwak

et al. 2020

Sci Rep

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Conservatives are more sensitive to threatening/anxious situations in perceptual and cognitive levels, experiencing emotional responses and stress, while liberals are more responsive to but tolerant of ambiguous and uncertain information. Interestingly, conservatives have greater psychological well-being and are more satisfied with their lives than liberals despite their psychological vulnerability to stress caused by threat and anxiety sensitivities. We investigated whether conservatives have greater resilience and self-regulation capacity, which are suggested to be psychological buffers that enhance psychological well-being, than liberals and moderates. We also explored associations between intrinsic functional brain organization and these psychological resources to expand our neurobiological understanding of self-regulatory processes in neuropolitics. We found that conservatives, compared to liberals and moderates, had greater psychological resilience and self-regulation capacity that were attributable to greater impulse control and causal reasoning. Stronger intrinsic connectivities between the orbitofrontal cortex (OFC) and precuneus and between the insula and frontal pole/OFC in conservatives were correlated with greater resilience and self-regulation capacity. These results suggest the neural underpinnings that may allow conservatives to manage the psychological stress and achieve greater life satisfaction. This study provides neuroscientific evidence for the different responses of liberals and conservatives to politically relevant social issues.

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“…Instead of focusing on pathology, research on positive neuroscience directs its attention on the neural mechanisms supporting flourishing, psychological well-being, resilience, and promotion of health. Previous studies have investigated the structural and functional neural basis underlying positive human functioning such as well-being (e.g., Van Reekum et al, 2007;Heller et al, 2013;Kong et al, 2015a;Sato et al, 2015), meditation (e.g., Cahn and Polich, 2006;Sperduti et al, 2012), optimism (e.g., De Pascalis et al, 2013, resilience (e.g., Kong et al, 2015bKong et al, , 2018, and creativity (e.g., Fink et al, 2009), based on experimental and self-reported measures. However, this emerging literature is just the tip of the iceberg on the quest to identify the complex mechanisms of brain structure and function supporting human behavior.…”

Section: Positive Neuroscience: the Neuroscience Of Human Flourishingmentioning

confidence: 99%

Editorial: Positive Neuroscience: the Neuroscience of Human Flourishing

Kong

Heller

Reekum

et al. 2020

Front. Hum. Neurosci.

Self Cite

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The burgeoning subfield of neuroscience focused on salubrious attributes of the human condition has begun to illuminate the complex biological basis of human functioning and flourishing. This has been referred to as positive neuroscience. Instead of focusing on pathology, research on positive neuroscience directs its attention on the neural mechanisms supporting flourishing, psychological well-being, resilience, and promotion of health. Previous studies have investigated the structural and functional neural basis underlying positive human functioning such as well-being (e.g., Van Reekum et al.on experimental and self-reported measures. However, this emerging literature is just the tip of the iceberg on the quest to identify the complex mechanisms of brain structure and function supporting human behavior. The Research Topic "Positive neuroscience: the neuroscience of human flourishing" provides an outlet for novel work in this domain and to advance our understanding of the underlying mechanisms of aspects of human flourishing.Kress and Aue begin this topic with a behavioral study on the effect of attention bias modification on optimism bias-that is, being overly optimistic-for future positive events. They found that extensive training in which subjects were required to direct attention to positive social information could enhance comparative optimism bias for future positive events, over, and above trait optimism.Wang et al. used an activation likelihood estimation (ALE) meta-analysis of functional magnetic resonance imaging (fMRI) studies to investigate whether neural systems involved in prosocial behaviors and reward demonstrated overlapping or distinct neural signatures. They found that prosocial behaviors specifically activated the insula, temporal lobe, and superior temporal gyrus (STG), whereas reward specifically activated the lentiform nucleus, thalamus, caudate nucleus, parahippocampal gyrus (PHG), and anterior cingulate cortex (ACC). Relatedly, Tunison et al. more specifically report on an event-related potential (ERP) component associated with reward processing, the reward-related positivity (RewP). The RewP is a positive deflection ERP component observed between 250 and 350 ms after reward feedback over fronto-central electrode sites, and its amplitude has been related to internalizing psychopathology. However, the RewP has been examined almost exclusively in response to financial rewards, and whether this ERP component is a general feature of reward processing remains uncertain. To address this, Tunison et al. used a point-based system of reward and found that RewP amplitudes were indeed larger for rewarded trials vs. non-rewarded trials. These data add to a growing literature that there are general properties of incentives regardless of the reward type.

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The resilient brain: psychological resilience mediates the effect of amplitude of low-frequency fluctuations in orbitofrontal cortex on subjective well-being in young healthy adults

Cited by 69 publications

References 91 publications

Stress and the brain: Perceived stress mediates the impact of the superior frontal gyrus spontaneous activity on depressive symptoms in late adolescence

Stress and the brain: Perceived stress mediates the impact of the superior frontal gyrus spontaneous activity on depressive symptoms in late adolescence

Intrinsic functional connectivity of blue and red brains: neurobiological evidence of different stress resilience between political attitudes

Editorial: Positive Neuroscience: the Neuroscience of Human Flourishing

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