The Resistance of C'142 Coated Cells to Complement Hemolysis by Cold Agglutinin

Cold Auto-Agglutinins

“…Other investigators have shown that cells from patients with the cold agglutinin syndrome are more resistant than normal cells to agglutination by anti-I anti body, to adsorption of labelled cold agglutinin, and to complement lysis. The available evidence indicates that this is due to accumulation of complement components on the red cell surface in instances where this accumulation stops short of haemolysis [24].…”

Cold Auto‐Agglutinins

“…Other investigators have shown that cells from patients with the cold agglutinin syndrome are more resistant than normal cells t o agglutination by anti-I antibody, t o adsorption of labelled cold agglutinin, and to complement lysis. The available evidence indicates that this is due t o accumulation of complement components on the red cell surface in instances where this accumulation stops short of haemolysis [24].…”