The resistance within: Antibiotic disruption of the gut microbiome and resistome dynamics in infancy

Thänert, Robert; Sawhney, Sanjam S.; Schwartz, Drew J.; Dantas, Gautam

doi:10.1016/j.chom.2022.03.013

Cited by 36 publications

(28 citation statements)

References 63 publications

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“…The antibiotic resistome is a core characteristic of the infant gut microbiota, 32 and the resistome burden correlates with cumulative antibiotic exposure. 7 To discern the effects of probiotic supplementation, antibiotic exposure, and differences in GA on the resistome dynamics, we searched the metagenomic data against the CARD database and analysed the resulting resistome profiles independently of the microbiota composition.…”

Section: Resultsmentioning

confidence: 99%

“… 31 The gut mobilome, the assortment of MGEs, including plasmids, transposons, integrons, and insertion sequences, contributes to the spread of ARGs within gut microbiota. 32 Preterm infants’ mobilome is associated with hospital location, 33 as well as their mothers’ mobilome, 27 which has been recently suggested to shape infant gut microbial assembly and metabolism. 34 However, there is a paucity of information on the short- and long-term effects of microbiota-modifying treatments on the resistome and mobilome profiles in newborns of different gestational age (GA).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Development of early life gut resistome and mobilome across gestational ages and microbiota-modifying treatments

Bargheet¹,

Klingenberg²,

Esaiassen³

et al. 2023

eBioMedicine

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Development of early life gut resistome and mobilome across gestational ages and microbiota-modifying treatments

Bargheet¹,

Klingenberg²,

Esaiassen³

et al. 2023

eBioMedicine

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“…Bacteriophage related therapies are in the concern once more ( 265 ). In addition, there has been also some progress in the relationship between intestinal flora and antibiotic resistance ( 266 ), the effect of antibiotics on intestinal flora ( 267 ), the effect of vaccines on antibiotic resistance ( 268 ), and antibiotic-resistant bacterial inhibitors ( 269 ). However, these studies are not thorough enough ( 270 , 271 ).…”

Section: Discussionmentioning

confidence: 99%

Antibiotic resistant bacteria: A bibliometric review of literature

Sun

Zhang

Dong

et al. 2022

Front. Public Health

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Antibiotic-resistant bacteria (ARB) are a serious threat to the health of people and the ecological environment. With this problem becoming more and more serious, more countries made research on the ARB, and the research number has been sharply increased particularly over the past decade. Therefore, it is quite necessary to globally retrace relevant researches on the ARB published from 2010 to 2020. This will help researchers to understand the current research situation, research trends and research hotspots in this field. This paper uses bibliometrics to examine publications in the field of ARB from 2010 to 2020 that were retrieved from the Web of Science (WOS). Our study performed a statistical analysis of the countries, institutions, journals, authors, research areas, author keywords, Essential Science Indicators (ESI) highly cited papers, and ESI hotspots papers to provide an overview of the ARB field as well as research trends, research hotspots, and future research directions in the field. The results showed that the number of related studies is increasing year by year; the USA is most published in the field of ARB; China is the most active in this field in the recent years; the Chinese Acad Sci published the most articles; Sci. Total Environ. published the greatest number of articles; CM Manaia has the most contributions; Environmental Sciences and Ecology is the most popular research area; and “antibiotic resistance,” “antibiotics,” and “antibiotic resistance genes” were the most frequently occurring author keywords. A citation analysis showed that aquatic environment-related antibiotic resistance is a key research area in this field, while antimicrobial nanomaterial-related research is a recent popular topic.

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“…The associations between antibiotic use, microbiome perturbation and ill-health are particularly relevant in early life. Antibiotics in infancy are associated with reduced gut microbiota diversity, AMR gene enrichment and altered longitudinal microbiome evolution relative to untreated infants [27 ▪ ]. Meta-analyses show that infants receiving antibiotics are 37% more likely to develop asthma than untreated infants, and 82% more likely if antibiotics are given in the first week of life [28 ▪▪ ].…”

Section: Host Factors Mattermentioning

confidence: 99%

Microbiotoxicity: antibiotic usage and its unintended harm to the microbiome

Theodosiou

Jones

Read

et al. 2023

Current Opinion in Infectious Diseases

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Purpose of review Antibiotic use is associated with development of antimicrobial resistance and dysregulation of the microbiome (the overall host microbial community). These changes have in turn been associated with downstream adverse health outcomes. This review analyses recent important publications in a rapidly evolving field, contextualizing the available evidence to assist clinicians weighing the potential risks of antibiotics on a patient's microbiome. Recent finding Although the majority of microbiome research is observational, we highlight recent interventional studies probing the associations between antibiotic use, microbiome disruption, and ill-health. These studies include germ-free mouse models, antibiotic challenge in healthy human volunteers, and a phase III study of the world's first approved microbiome-based medicine. Summary The growing body of relevant clinical and experimental evidence for antibiotic-mediated microbiome perturbation is concerning, although further causal evidence is required. Within the limits of this evidence, we propose the novel term ‘microbiotoxicity’ to describe the unintended harms of antibiotics on a patient's microbiome. We suggest a framework for prescribers to weigh microbiotoxic effects against the intended benefits of antibiotic use.

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The resistance within: Antibiotic disruption of the gut microbiome and resistome dynamics in infancy

Cited by 36 publications

References 63 publications

Development of early life gut resistome and mobilome across gestational ages and microbiota-modifying treatments

Development of early life gut resistome and mobilome across gestational ages and microbiota-modifying treatments

Antibiotic resistant bacteria: A bibliometric review of literature

Microbiotoxicity: antibiotic usage and its unintended harm to the microbiome

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