The Resolution of t-Butyloxycarbonyl-Dl-α-phenylsarcosine

Preparation and isolation of 2-methylamino-3-phenylpropanoic acid enantiomers using selective crystallization

“…Therefore, esters and N-acyl derivatives of DL-␣-amino acids have been subjected to optical resolution by diastereomeric method. For example, N-acetyl and N-tbutyloxycarbonyl derivatives of (RS)-MPA have been optically resolved by using brucine 3 and ephedrine, 4 respectively, as resolving agents. Although N-acyl derivatives of (RS)-MPP may also be optically resolved using a basic resolving agent, the transformation into the N-acyl derivatives and regeneration of optically active MPP from the resolved derivatives are tedious and result in low yield as well as in partial racemization.…”