The Response of Chicks, Ducklings, Goslings, Pheasants and Poults to Graded Levels of Aflatoxins

Muller, R. D.; Carlson, C. W.; Semeniuk, G.; Harshfield, G. S.

doi:10.3382/ps.0491346

Cited by 67 publications

(31 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our results indicated the hemorrachagic anemia syndrome caused by AFB 1 was characterized by pethecial and larger hemorrhages into the musculature and internal organs in treatment 2 and 4 of animals. This is in agreement with results obtained Muller (1970). Lipids in liver increased in broiler chicks fed diet with AFB 1 (Smýth, 1970).…”

Section: Resultssupporting

confidence: 92%

Reduction of toxic effects of aflatoxin B1 by using baker yeast (Saccharomyces cerevisiae) in growing broiler chicks diets

2003

View full text Add to dashboard Cite

-This study was carried out to investigate the effects of adding baker yeast (BY), chlortetracycline (CTC) and both BY + CTC to a control diet containing 200 ng/g of aflatoxin B 1 (C + AFB 1 ) on performance, serum parameters and pathologyc alterations of broilers. A total 100 chicks (Ross PM 3) were divided into five groups in individual cages and each containing 20 animals. BY, a rich source of protein and vitamin B complex, was mixed into the diets at 2.0 %, CTC was mixed into the diet at 2.5 ng/g. Feed consumption, body weight and feed efficiency were recorded weekly. Serum parameters and pathologyc alterations were determined at the end of the study. Dead animals were recorded daily. Liver changes were clearly apparent in the C+AFB 1 and C+ AFB 1 +CTC most of the livers were enlarged, yellow and had pethecial hemorrhages. Canalicula cholestosis was absent in group C+AFB 1 and C+ AFB 1 +CTC, but not others. When compared to the control (C) group, alkaline phosphatase (ALP), appear to be significantly increased in the C+AFB 1 and C+CTC+ AFB 1 groups. Serum glutamic oxalacetic transaminase (GOT)was increased in C+AFB 1 birds. Serum alphaphetoprotein was not affected by the treatments. Feed consumption and body weight were significantly reduced in group AFB 1 . Birds receiving BY + AFB 1 , CTC + AFB 1 and BY + CTC + AFB 1 had a significantly higher body weight than group C+AFB 1 . Feed efficiency was better in group CTC + AFB 1 than the others. The findings of this research suggest tha BY (2%) can partly counteract some of the toxic effects of AFB 1 . RESUMO -Este estudo foi desenvolvido para avaliar os efeitos da adição de Levedura de panificação (BY) e cortetraciclina (CTC) e ambos BY+CTC a uma dieta controle © contendo 200 ng/g de aflatoxina B1 (C+AFB1) sobre desempenho, parâmetros séricos e alterações patológicas de frangos de corte. Um total de 100 pintinhos (Ross PM3) foi dividido em cinco grupos, em gaiolas individuais, contendo 20 animais para cada grupo. A levedura de panificação, uma fonte rica de proteína e vitamina do complexo B foi adicionada à dieta, à porcentagem de 2% e a CTC, a 2.5 ng/g. Consumo alimentar, peso corporal e eficiência alimentar foram registrados semanalmente. Parâmetros séricos e alterações patológicas foram determinados no final do estudo. Animais mortos foram registrados diariamente. Alterações ocorridas no fígado foram claramente aparentes nas dietas C+AFB1 e C+AFB1+CTC, sendo que a maioria dos fígados apresentou-se aumentado, amarelo e com hemorragia peticial. Canícula colestoses foi ausente nos grupos C+AFB1 e C+AFB1=CTC, mas não nos demais grupos. Quando comparado com o grupo controle©, alcalino fosfatase (ALP), parece que houve aumento significativo nos grupos C+AFB1 e C=CTC=AFB1. O xaloacético tansaminase glutâmico (GOT) sérico foi maior no grupo de aves C+AFB1. A lphafetoproteína sérica não foi afetada pelos tratamentos. Consumo alimentar e peso corporal foram significativamente reduzidos no grupo AFB1. Animais que receberam BY+AFB1, CTC+AFB1 e BY+CTC+AFB1 tiver...

show abstract

Section: Resultssupporting

confidence: 92%

Reduction of toxic effects of aflatoxin B1 by using baker yeast (Saccharomyces cerevisiae) in growing broiler chicks diets

2003

View full text Add to dashboard Cite

show abstract

“…Poultry are sensitive to even low levels of AFB1, and among species of agricultural importance, the order of sensitivity is ducks > turkeys > Japanese quail (Coturnix japonica) > chickens [7,21,[72][73][74][75]. Therefore, lower concentrations of AFB1 are lethal to turkeys and ducks and more adversely affect production and health in these species (Table 2).…”

Section: Sensitivity: Poultrymentioning

confidence: 99%

Aflatoxicosis: Lessons from Toxicity and Responses to Aflatoxin B1 in Poultry

2015

View full text Add to dashboard Cite

This review is a comprehensive introduction to the effects of poultry exposure to the toxic and carcinogenic mycotoxin aflatoxin B1 (AFB1). The relationship between AFB1 sensitivity and metabolism, major direct and indirect effects of AFB1, recent studies of gene expression and transcriptome responses to exposure, and mitigation strategies to reduce toxicity are discussed. Exposure to AFB1 primarily occurs by consumption of contaminated corn, grain or other feed components. Low levels of residual AFB1 in poultry feeds can cause reduction in growth, feed conversion, egg production, and compromised immune functions, resulting in significant economic costs to producers. Thus, AFB1 acts as a "force multiplier" synergizing the adverse effects of microbial pathogens and other agents, and factors detrimental to poultry health. Domestic turkeys (Meleagris gallopavo) are one of the most sensitive animals known to AFB1 due, in large part, to a combination of efficient hepatic bioactivation by cytochromes P450 1A5 and 3A37, and deficient hepatic glutathione-S-transferase (GST)-mediated detoxification. Because of their sensitivity, turkeys are a good model to investigate chemopreventive treatments and feed additives for their ability to reduce AFB1 toxicity. Transcriptome analysis (RNA-seq) of turkey poults (liver and spleen) has identified AFB1-induced gene expression changes in pathways of apoptosis, carcinogenesis, lipid regulation, antimicrobial activity, cytotoxicity and antigen presentation. Current research focuses on further identifying the molecular mechanisms OPEN ACCESSAgriculture 2015, 5 743 underlying AFB1 toxicity with the goal of reducing aflatoxicosis and improving poultry health.

show abstract

“…Com relação às espécies exploradas na avicultura comercial, a susceptibilidade é maior em patos, seguidos de perus, gansos, faisões e frangos (MULLER et al, 1970). Mesmo entre indivíduos de uma mesma espécie, a relação dose-resposta pode variar de acordo com raça, sexo, idade e composição da dieta, entre outros fatores (COULOMBE, 1991).…”

Section: Introductionunclassified

Alterações hepáticas em codornas japonesas submetidas à intoxicação prolongada por aflatoxina B1

et al. 2004

View full text Add to dashboard Cite

The Response of Chicks, Ducklings, Goslings, Pheasants and Poults to Graded Levels of Aflatoxins

Cited by 67 publications

References 6 publications

Reduction of toxic effects of aflatoxin B1 by using baker yeast (Saccharomyces cerevisiae) in growing broiler chicks diets

Reduction of toxic effects of aflatoxin B1 by using baker yeast (Saccharomyces cerevisiae) in growing broiler chicks diets

Aflatoxicosis: Lessons from Toxicity and Responses to Aflatoxin B1 in Poultry

Alterações hepáticas em codornas japonesas submetidas à intoxicação prolongada por aflatoxina B1

Contact Info

Product

Resources

About