The response of circulating omentin-1 concentration to 16-week exercise training in male children with obesity

Zehsaz, Farzad; Farhangi, Negin; Ghahramani, Mehri

doi:10.1080/00913847.2016.1248223

Cited by 26 publications

(38 citation statements)

References 41 publications

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“…We are not able to differentiate the effect of diet, increased physical exercise and weight status per se on omentin‐1 concentrations due to our study protocol. Previous studies reported that physical activity lead to an increase of omentin‐1 in boys with obesity and aerobic physical exercises increased the omentin‐1 concentration in adults . Caloric restriction also seems to influence serum omentin‐1 levels.…”

Section: Discussionmentioning

confidence: 84%

“…Circulating omentin‐1 is down‐regulated in obesity and type 2 diabetes and increases after weight loss . In children, omentin‐1 has been reported to be related negatively to weight status, physical exercise, metabolic syndrome and inflammation . However, another paediatric study did not find an association between fat mass or body weight and omentin‐1 …”

Section: Introductionmentioning

confidence: 98%

“…status, physical exercise, metabolic syndrome and inflammation. [10][11][12] However, another paediatric study did not find an association between fat mass or body weight and omentin-1. 13 Even though the physiological role of omentin-1 is not fully understood, omentin-1 has been shown to increase insulin-mediated glucose uptake, especially in the adipose tissue.…”

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confidence: 97%

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Link between omentin‐1, obesity and insulin resistance in children: Findings from a longitudinal intervention study

et al. 2019

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Objective The adipokine omentin‐1 has been suggested to be inversely associated with obesity and insulin resistance in humans. We studied the relationships between omentin‐1, parameters of fat mass, insulin resistance, lipids and blood pressure in children with obesity in a longitudinal study. Methods We analysed omentin‐1 concentrations in 23 normal‐weight children and in 82 children with obesity participating in a one‐year lifestyle intervention. In the children with obesity, omentin‐1, bioactive and conventional leptin, thyroid hormones (thyroid‐stimulating hormone, free thyroxine 4, free triiodothyronine), body mass index, waist circumference, body fat based on skin‐fold measurements and bioimpedance analyses, lipids, insulin resistance as homeostatic model assessment of insulin resistance (HOMA‐IR) and blood pressure were determined at baseline and 1 year later. Furthermore, we measured omentin‐1 concentrations 1 year after the end of the lifestyle intervention. Results The omentin‐1 concentrations were significantly (P = .008) lower in children with obesity compared to normal‐weight children (296 ± 108 ng ml−1 vs. 232 ± 99 ng ml−1). Omentin‐1 concentrations increased significantly (P < .001) in children with obesity and substantial weight loss (35 ± 55 ng ml−1), while omentin‐1 concentrations did not change significantly (P = .750) in children with obesity without weight loss (−5 ± 108 ng ml−1) during the intervention. Substantial weight loss after the end of intervention led to a significant (P < .001) increase of omentin‐1 concentrations (+64 ± 14 ng ml−1). Omentin‐1 was significantly and negatively associated with HOMA‐IR both in cross‐sectional (r = −.27, P = .006) and longitudinal analyses (r = −.33, P = .001). Omentin‐1 concentrations were not related to pubertal stage, sex or thyroid hormones. Conclusions Our data do support the hypothesis that omentin‐1 is reversibly decreased in obesity and is a link between obesity and insulin resistance.

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Section: Discussionmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 98%

mentioning

confidence: 97%

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Link between omentin‐1, obesity and insulin resistance in children: Findings from a longitudinal intervention study

et al. 2019

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“…Negative significant correlations between omentin-1 changes and changes in BMI, waist circumference, body fat percent, fasting serum insulin levels and HOMA2-IR were also found. Based on the results of multiple linear regression analyses, the authors revealed that changes of BMI and insulin levels were independent predictors of the difference observed in serum omentin-1 levels after an exercise program [ 24 ].…”

Section: Omentinmentioning

confidence: 99%

Role of Omentin, Vaspin, Cardiotrophin-1, TWEAK and NOV/CCN3 in Obesity and Diabetes Development

Escoté

Gómez‐Zorita

López-Yoldi

et al. 2017

IJMS

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Adipose tissue releases bioactive mediators called adipokines. This review focuses on the effects of omentin, vaspin, cardiotrophin-1, Tumor necrosis factor-like Weak Inducer of Apoptosis (TWEAK) and nephroblastoma overexpressed (NOV/CCN3) on obesity and diabetes. Omentin is produced by the stromal-vascular fraction of visceral adipose tissue. Obesity reduces omentin serum concentrations and adipose tissue secretion in adults and adolescents. This adipokine regulates insulin sensitivity, but its clinical relevance has to be confirmed. Vaspin is produced by visceral and subcutaneous adipose tissues. Vaspin levels are higher in obese subjects, as well as in subjects showing insulin resistance or type 2 diabetes. Cardiotrophin-1 is an adipokine with a similar structure as cytokines from interleukin-6 family. There is some controversy regarding the regulation of cardiotrophin-1 levels in obese -subjects, but gene expression levels of cardiotrophin-1 are down-regulated in white adipose tissue from diet-induced obese mice. It also shows anti-obesity and hypoglycemic properties. TWEAK is a potential regulator of the low-grade chronic inflammation characteristic of obesity. TWEAK levels seem not to be directly related to adiposity, and metabolic factors play a critical role in its regulation. Finally, a strong correlation has been found between plasma NOV/CCN3 concentration and fat mass. This adipokine improves insulin actions.

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“…A 16-week exercise training programme resulted in a significant increase in serum omentin-1 concentrations in obese children. The authors suggest that exercise-induced changes in omentin-1 may be associated with the beneficial effects of exercise on reduced insulin and weight loss [172]. Numerous research papers show that omentin concentration was inversely correlated with glucose metabolism markers [54,113,150,173].…”

Section: Adipokinesmentioning

confidence: 99%

The roles of vaspin, chemerin, and omentin in the determination of metabolic syndrome

Suliga¹,

Wawszczak²,

Głuszek³

2018

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Metabolic syndrome (MetS) is defined as multiple risk factors including abdominal obesity, dyslipidaemia, abnormal glycaemia, and elevated blood pressure. The incidence of MetS and pathophysiological mechanisms underlying its development are still not fully understood. It is thought that the occurrence of MetS arises from the complex relationship between genetic and environmental factors. The aim of the study was to overview and summarise current knowledge regarding genetic determinants of MetS. Also analysed were the relationship between polymorphisms of the genes encoding selected adipokines (vaspin, chemerin, omentin) and the risk of MetS, as well as other metabolic disorders. The precise determination of MetS genotype is difficult because metabolic syndrome occurrence is a combination of multiple risk factors. A thorough understanding of pathomechanisms of MetS, involving selected adipokines, may in the future allow the use of these adipokines as potential biomarkers of metabolic disorder risk.

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The response of circulating omentin-1 concentration to 16-week exercise training in male children with obesity

Abstract: Exercise training resulted in a significant increase in serum omentin-1 concentrations in children with obesity. The ﬁndings suggest that exercise-induced changes in omentin-1 may be associated with the beneﬁcial effects of exercise on reduced insulin and weight lost.

Cited by 26 publications

References 41 publications

Link between omentin‐1, obesity and insulin resistance in children: Findings from a longitudinal intervention study

Link between omentin‐1, obesity and insulin resistance in children: Findings from a longitudinal intervention study

Role of Omentin, Vaspin, Cardiotrophin-1, TWEAK and NOV/CCN3 in Obesity and Diabetes Development

The roles of vaspin, chemerin, and omentin in the determination of metabolic syndrome

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