The Response of Endogenously and Reactively Depressed Patients to Electroconvulsive Therapy

Vlissides, D N; Jenner, F. A.

doi:10.1192/bjp.141.3.239

Cited by 19 publications

(7 citation statements)

References 5 publications

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“…Our NEDDI endogenous depressive patients exhibited a higher severity level than neurotic depressives, as shown by a 100% diagnosis of RDC MDD and by the total HRSD score. These results showing a different severity level between the groups are in accordance with some (16,27,29,(40)(41)(42)(43) but not all studies (13,17,21,23,28,30,33,44). Selection procedures could account for these discrepancies.…”

Section: Discussionsupporting

confidence: 89%

“…Moreover, free urinary cortisol (1 7), corticosteroid response to metamphetamine ( 18), platelet monoamine oxidase activity (19), erythrocyte sodium level (20), regional cerebral blood flow (21) and skin conductance (22,23) might also differentiate endogenous from neurotic depressive patients. Second, of the operational definitions proposed to identify endogenous or melancholic depression, the validity of the NEDDI was the most frequently supported (16) when biological (15,24,25), therapeutic (26)(27)(28)(29)(30), familial (31) or psychosocial criteria (32,33) were used.…”

mentioning

confidence: 99%

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Biological correlates of the Newcastle Scale in depressive illness: a multivariate approach

Staner¹,

Maes

Bouillon³

et al. 1992

Acta Psychiatr Scand

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Rapid eye movement latency (RL), delta max thyroid-stimulating hormone (dmTSH) and 1600 (DST16) and 2300 (DST23) post-dexamethasone cortisol values were determined in a group of 93 depressed patients who were assessed with the Newcastle Endogenous Depression Diagnostic Index (NEDDI). After the effects of age, gender and severity of illness were controlled for, stepwise multiple regression showed that depressive psychomotor activity and weight loss were the 2 NEDDI items most contributing to explain DST23 variance, as was depressive psychomotor activity for dmTSH variance. When the depressive sample was dichotomized according to the presence of these 2 items, the 2 groups had significantly different DST16, DST23, dmTSH and RL values. This suggests that weight loss, agitation and retardation could represent a core feature of a biologically mediated depressive subtype.

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Section: Discussionsupporting

confidence: 89%

mentioning

confidence: 99%

Biological correlates of the Newcastle Scale in depressive illness: a multivariate approach

Staner¹,

Maes

Bouillon³

et al. 1992

Acta Psychiatr Scand

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“…We adjusted for the following potential confounders in our final regression models: age, gender, number of sessions in the series, psychiatric comorbidity (anxiety disorders, substance misuse and personality disorder) and psychiatric pharmacotherapies (antidepressants, anti-epileptics, antipsychotics, benzodiazepines and lithium). The choice of covariates in our model was based on a variable being a known confounder, such as age, [24][25][26][27] or a potential confounder based on clinical reasoning.…”

Section: Discussionmentioning

confidence: 99%

The effect of anaesthetic dose on response and remission in electroconvulsive therapy for major depressive disorder: nationwide register-based cohort study

et al. 2021

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Background Electroconvulsive therapy (ECT) is a safe and effective treatment for major depressive disorder (MDD). ECT treatment effect relies on induced generalised seizures. Most anaesthetics raise the seizure threshold and shorten seizure duration. There are no conclusive studies on the effect of anaesthetic dose on response and remission rates with ECT for MDD. Aims We aimed to examine the effect of different dose intervals of anaesthetics on response and remission after ECT for MDD. Method We conducted a nationwide cohort study, using data from Swedish registers. Low-, medium- and high-dose intervals, adjusted for age and gender, were constructed for each anaesthetic drug. Response and remission were measured with the Clinical Global Impression – Severity and Improvement scales (CGI-I and CGI-S), and a self-rated version of the Montgomery–Åsberg Depression Rating Scale (MADRS-S). Logistic regression models were used to calculate adjusted odds ratios for response and remission rates. Results The study included 7917 patients who received ECT for MDD during 2012–2018. Patients were given either thiopental (64.1%) or propofol (35.9%). Low-dose intervals of anaesthetics were associated with increased rates of response (CGI-I: odds ratio 1.22, 95% CI 1.07–1.40, P = 0.004; MADRS-S: odds ratio 1.31, 95% CI 1.09–1.56, P = 0.004) and remission (CGI-S: odds ratio 1.37, 95% CI 1.17–1.60, P ≤ 0.001; MADRS-S: odds ratio 1.31, 95% CI 1.10–1.54, P = 0.002). Conclusions We found improved treatment outcomes with low- compared with high-dose anaesthetic during ECT for MDD. To enhance treatment effect, deep anaesthesia during ECT for MDD should be avoided.

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“…The same authors [6] subsequently carried out a blind assessment 1 month after ECT of 165 depressed patients who had been rated on the Newcastle Scale previous to treatment in the course of several research projects. The predictive value of the Newcastle Scale in depressed patients treated with ECT has also been confirmed by Vlissades and Jenner [76]. There was a striking difference between them in terms of mean results of ECT, those with the Newcastle Score> 6 (endogenous) doing better.…”

Section: Treatmentmentioning

confidence: 59%

Assessment of Depression

Sartorius¹,

Ban²

1986

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The Response of Endogenously and Reactively Depressed Patients to Electroconvulsive Therapy

Cited by 19 publications

References 5 publications

Biological correlates of the Newcastle Scale in depressive illness: a multivariate approach

Biological correlates of the Newcastle Scale in depressive illness: a multivariate approach

The effect of anaesthetic dose on response and remission in electroconvulsive therapy for major depressive disorder: nationwide register-based cohort study

Assessment of Depression

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