1965
DOI: 10.1172/jci105143
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The Response of Extracellular Hydrogen Ion Concentration to Graded Degrees of Chronic Hypercapnia: The Physiologic Limits of the Defense of pH*

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Cited by 162 publications
(55 citation statements)
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“…The ranges of arterial Pacom, hydrogen ion, and plasma bicarbonate concentrations obtained before the acute titrations in animals studied at the six levels of arterial carbon dioxide tension are presented in Table II. A regression line relating hydrogen ion concentration and Paco2 calculated from these data yielded the equation, He = 0.27Pacom + 32.9; this equation is closely similar to that previously reported in dogs adapted to chronic hypercapnia (H' =0.32 Paco2+ 26.9 [7]). …”
Section: Methodssupporting
confidence: 82%
See 1 more Smart Citation
“…The ranges of arterial Pacom, hydrogen ion, and plasma bicarbonate concentrations obtained before the acute titrations in animals studied at the six levels of arterial carbon dioxide tension are presented in Table II. A regression line relating hydrogen ion concentration and Paco2 calculated from these data yielded the equation, He = 0.27Pacom + 32.9; this equation is closely similar to that previously reported in dogs adapted to chronic hypercapnia (H' =0.32 Paco2+ 26.9 [7]). …”
Section: Methodssupporting
confidence: 82%
“…The The Journal of Clinical Investigation Volume 50 1971 was maintained between 20 and 21%go in all studies. The animals were kept at a given level of arterial carbon dioxide tension for 6 days, a period which has been demonstrated to be adequate for the development of a new steady state of acid-base equilibrium (7). All These preliminary studies demonstrated an average net alkali excretion of 15 mEq during the acute C02 titration; net alkali excretion during an identical time interval 2 days earlier (during which the C02 tension was maintained at a constant hypercapnic level) was 6 mEq.…”
Section: Methodsmentioning
confidence: 99%
“…In dogs, a new steady state emerges within 3 to 5 days. 6,7 Whether this temporal pattern applies to humans is unknown. In patients, chronic hypercapnia often reflects gradual deterioration in pulmonary function; consequently, the secondary response might keep pace with the slowly rising PaCO 2 without a perceptible delay.…”
Section: Magnitude and Time Course Of The Secondary Responsesmentioning
confidence: 99%
“…Figure 1 presents the dayto-day changes in acid-base parameters of plasma for a representative study (dog 57). Detailed balance data for this dog are shown in Table I (1).…”
Section: Introductionmentioning
confidence: 99%