The response of rabbit patellar tendons after autologous blood injection

Abstract

We found that injecting blood directly into normal tendons appears safe. Further evaluation of this technique would appear indicated.

Use of platelet-rich plasma for the treatment of refractory jumper’s knee

“…Recently, some authors [15,16] have postulated that autologous blood injections might provide the necessary cellular and humoral mediators to induce the healing cascade and promote tendon repair. The rationale was based on the mitomorphogenic activity of blood growth factors and the inflammatory response induced in an otherwise degenerative process, leading to strengthening of the tendon through the formation of granulation tissue and tissue regeneration, in a tendon with an increased healing potential.…”

“…The rationale was based on the mitomorphogenic activity of blood growth factors and the inflammatory response induced in an otherwise degenerative process, leading to strengthening of the tendon through the formation of granulation tissue and tissue regeneration, in a tendon with an increased healing potential. The effect of autologous blood injections into the tendon have been evaluated in vitro and in vivo, whereby an increase in rabbit patellar tendon strength has been assessed [15]. Clinical applications for the treatment of chronic tendinopathies have also showed good results [16][17][18][19].…”

Ultrasound-guided intervention in the ankle and foot

“…18 Some of the initial studies were performed on rabbit tendons showing an increase in collagen Type 1 and increased maturity of repair tissue. 19 The use of autologous blood and dry needling in patellar tendinosis was published in 2007 by James et al 20 Platelet-rich plasma was introduced to reduce the after effect of the autologous blood, which can clot in the syringe and cause a lot of soreness because of the other factors within the blood which are irritants. A new product was therefore developed by centrifuging the blood and producing both protein-rich and protein-poor plasma.…”

Comparitive Study of Local Steroid Injection Versus Autologous Blood Injection Therapy for the Management of Lateral Epicondyliti S

“…5,6 Most current research has proposed degeneration of the origin of the extensor carpi radialis brevis and repeated microtrauma and incomplete healing response (Tendinosis) as the cause of lateral epicondylitis. [7][8][9][10][11] The constellation of findings has been termed angiofibroblastic hyperplasia. 12 Most conservative modalities such as local injection of corticosteroid have focused on suppressing an inflammatory process that does not actually exist.…”

“…13 Recently an injection of autologous blood has been reported to be effective for both intermediate and longterm outcomes for the treatment of lateral epicondylitis, with a significant decrease in pain. 6,11,14 Chemical modifiers of cellular activity carried in the blood and are known to be mitomorphogenic. 12 Injection of autologous blood might provide the necessary cellular and humeral mediators to induce a healing cascade.…”