The response of the rabbit eye to laser irradiation of the iris

Unger, W.G.; Perkins, E. S.; Bass, M.S.

doi:10.1016/0014-4835(74)90022-0

Cited by 70 publications

(25 citation statements)

References 16 publications

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“…The IO P elevation has been partly attributed to an elevation o f P G levels in the aqueous humor [8,9], to clogging o f the tra becular meshwork by debris and protein [10,11], and to inflammation o f the trabecular meshwork [10]. In animals, acute rises o f the IO P have been reported after laser irradiation o f the iris [8,12,13]. However, little attention has been paid to the hypotony after laser irra diation of the iris.…”

Section: Resultsmentioning

confidence: 99%

Biphasic Intraocular Pressure Response to Laser Irradiation of the Iris in Rabbits

Kim

Lee²

1995

Ophthalmic Res

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The possibility of an acute increase in intraocular pressure (IOP) following laser iridotomy is well known. However, little attention has been paid to the hypotony after laser irradiation of the iris. We performed this study to evaluate the effect of laser irradiation of the iris on the IOP in pigmented rabbits. IOP, aqueous flare values, and aqueous prostaglandin E₂ levels were measured before and 1,4, 12, and 24 h after argon laser treatment. The IOP showed a prolonged reduction for 24 h following an initial transient increase. Flare values and aqueous prostaglandin E₂ levels reached a peak 1 h after laser treatment, followed by a progressive reduction. Argon laser peripheral iridoplasty that can separate the iris from the trabecular meshwork by the mechanical force resulting from a contraction burn is used sometimes in treating angle-closure glaucoma. Our results showed that the laser irradiation of the iris itself can cause ocular hypotony, so that this phenomenon may be another explanation of the IOP response after peripheral iridoplasty.

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Section: Resultsmentioning

confidence: 99%

Biphasic Intraocular Pressure Response to Laser Irradiation of the Iris in Rabbits

Kim

Lee²

1995

Ophthalmic Res

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“…Stimulation of the pigmented rabbit iris with the ruby laser elicits an acute, transient inflammatory response which is partly me diated by E-type prostaglandin (PG) and inhibited by aspirin-like compounds [Unger et al, 1974;Neufeld et al, 1972], Like oth er forms of ocular trauma, chemical or mechanical, the laser-induced reaction is resistant to atropine but most likely involves an excitatory nervous element fDuke-Elder and Duke-Elder, 1931;Davson and Huber, 1950;Ambache et al, 1965;Sears, 1960;Beitch and Eaklns, 1969;Cole and Unger, 1973], Since the ruby laser emits a 0.6-msec pulse train, the ocular response to irradia tion probably results from mechanical dis ruption of tissue due to a sudden absorption of intense laser light [Cleary and Hamrick, 1969;Marshall, 1970;Fraunfelder and Viernstein, 1971], The argon laser, how ever, generates a continuous light wave, so that its biological effect is caused primarily by heat. In the present experiments the re sponse of the rabbit eye to argon laser irra diation of the iris and also the effect of a non-steroidal anti-inflammatory, PG synthe tase inhibitor (indomethacin) and a local anaesthetic (benoxinate) were investigated.…”

Section: Introductionmentioning

confidence: 99%

Prostaglandin and Nerve-Mediated Response of the Rabbit Eye to Argon Laser Irradiation of the Iris

Unger¹,

Bass²

1977

Ophthalmologica

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“…The involvement of PGE2 in various ocu lar diseases is well documented [4,5,[8][9][10][11][12][13]; it has been shown to have a mediatory role in the inflammatory process, causing polymor phonuclear cell chemotaxis, vasodilatation and increased permeability of blood vessels [1,2], Prostacyclin, generated by the vascu lar endothelium, is also involved in the in flammatory process, though to a lesser de gree [3], PGE2 and prostacyclin are the cyclo-oxy genase products of arachidonic acid [1][2][3], and their formation in the eye is initiated by various stimuli such as trauma, ischemia, nervous excitation and laser irradiation [13,[16][17][18][19], PGE2 produced by the retina is not stored but released into the vitreous [19], In disease-free subjects, vitreal PGE2 and pros tacyclin levels do not differ significantly from plasma levels [20,21],…”

Section: Discussionmentioning

confidence: 99%

Prostanoids in the Vitreous of Diabetic and Nondiabetic Human Eyes with Retinal Detachment

Naveh

Belkin²,

Ben-Chaim³

et al. 1990

Ophthalmic Res

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We measured prostaglandin E₂ (PGE₂) and prostacyclin levels in the vitreous bodies of 5 eyes of patients with diabetic retinopathy complicated by rhegmatogenous retinal detachment (RRD) and compared them with the corresponding levels in 9 nondiabetic eyes with the same condition as well as with 10 control eyes of deceased patients with no known ocular pathology. We also studied the effect of surgical retinal reattachment on vitreal PGE₂and prostacyclin levels in 4 eyes. Vitreal samples from both nondiabetic and diabetic eyes with RRD were obtained during vitrectomy, while samples from deceased subjects (controls) were obtained 2–6 h after death. Vitreal PGE₂ and prostacyclin levels in the control eyes approximated plasma levels (79.9 ± 20.5 and 124.5 ± 38.5 pg/ml, means ± SD, respectively), while RRD in the nondiabetic eyes was associated with increased levels of both PGE₂ and prostacyclin (3,170 ± 3,024 and 467 ± 283 pg/ml, respectively). In the diabetic eyes with diabetic retinopathy complicated by RRD, all of which underwent retinal photocoagulation, PGE₂ and prostacyclin levels were 2–4 times lower than those of the nondiabetic eyes with detached retina. Following surgical retinal reattachment, vitreal levels of both components in diabetics and nondiabetics showed a reduction suggesting that the surgical procedure for obtaining vitreal samples was not the cause for elevated prostaglandin levels in the eyes with detached retina. We showed that RRD is associated with an excessive accumulation of PGE₂ and prostacyclin in the vitreous, which is higher in nondiabetic than in diabetic eyes, indicating that diabetic retinopathy in laser-treated eyes might lead to reduced vitreal levels of these metabolites.

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The response of the rabbit eye to laser irradiation of the iris

Cited by 70 publications

References 16 publications

Biphasic Intraocular Pressure Response to Laser Irradiation of the Iris in Rabbits

Biphasic Intraocular Pressure Response to Laser Irradiation of the Iris in Rabbits

Prostaglandin and Nerve-Mediated Response of the Rabbit Eye to Argon Laser Irradiation of the Iris

Prostanoids in the Vitreous of Diabetic and Nondiabetic Human Eyes with Retinal Detachment

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