The response of thyroid hormones, biochemical and enzymological biomarkers to pyrene exposure in common carp (Cyprinus carpio)

Shirdel, Iman; Kalbassi, Mohammad Reza; Shokri, Milad; Olyaei, Roya; Sharifpour, I

doi:10.1016/j.ecoenv.2016.03.023

Cited by 27 publications

(10 citation statements)

References 66 publications

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“…The significant decrease in plasma glucose in unstressed fish exposed to PAHs after 7 d of exposure is not in agreement with the literature, which reports increases in plasma glucose with exposure to crude oil (Kennedy and Farrell 2005;Wegwu and Omeodu 2010;Shirdel et al 2016). An increase in plasma glucose is consistent with an activation of the endocrine stress response and a stimulation of the glucocorticoid hormones that increase plasma glucose concentrations in many fish (Wendelaar Bonga 1997;Mommsen et al 1999).…”

Section: Discussioncontrasting

confidence: 85%

Exposure and Recovery of the Gulf Toadfish (Opsanus beta) to Weathered Deepwater Horizon Slick Oil: Impacts on Liver and Blood Endpoints

Alloy

Cartolano

Sundaram

et al. 2021

Enviro Toxic and Chemistry

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Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous contaminants that can be responsible for a variety of deleterious effects on organisms. These adverse outcomes are relatively well studied, but at concentrations rarely found in the environment. Among the documented effects of sublethal acute PAH exposure are reductions in osmoregulatory capacity and immune function, and changes in the function of critical metabolic organs such as the liver. Gulf toadfish (Opsanus beta) were exposed to control seawater (0.006 µg tPAH 50 /L) or water accommodated fractions of Deepwater Horizon spill oil diluted to 3 flow-through exposure regimes (0.009, 0.059, and 2.82 µg tPAH 50 /L) for 7 d, with a recovery period of equal duration. We hypothesized that these chronic exposures would induce the aryl hydrocarbon receptor (AhR)-mediated pathways and result in significant impacts on markers of osmoregulatory, immune, and metabolic function. We further hypothesized that measurable reversal of these impacts would be observed during the recovery period. Our results indicate that activation of cytochrome P 450 (CYP)1A1 was achieved during exposure and reversed during the recovery phase. The only significant deviations from controls measured were a reduction in plasma glucose in fish exposed to medium and high levels of PAH after 7 d of exposure and a reduction in plasma osmolality fish exposed to high levels of PAHs after 7 d of recovery, when CYP1A1 messenger (m)RNA levels had returned to control levels. Our study illustrates a disconnect between the activation of CYP1A1 in response to environmentally realistic PAHs concentrations and several physiological endpoints and supports the idea that the AhR might not be associated with mediating osmoregulatory, immune, and metabolic changes in Gulf toadfish.

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Section: Discussioncontrasting

confidence: 85%

Exposure and Recovery of the Gulf Toadfish (Opsanus beta) to Weathered Deepwater Horizon Slick Oil: Impacts on Liver and Blood Endpoints

Alloy

Cartolano

Sundaram

et al. 2021

Enviro Toxic and Chemistry

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“…Furthermore, the levels of urea were not dangerous and the inclusion of DLP in the fish diet, at the level tested in the present study, did not affect the general metabolism of gilthead seabream. This crucial aspect was also confirmed from the trend of ALT and AST, which provide information of liver welfare status, protein metabolism and energy management (Bulfon et al, ; Ismail & Mahboub, ; Shirdel et al, ) and are also indicators of stress (Ismail & Mahboub, ; Shirdel et al, ; Tkachenko & Grudniewska, ). High values of ALT and AST for prolonged time are related with hepatic damage or a disturbance in the Krebs cycle, and may indicate cellular necrosis (Ismail & Mahboub, ).…”

Section: Discussionmentioning

confidence: 79%

“…In stress situations there are changes in the metabolism, and plasma glucose and lactate levels increase (Laiz-Carrión et al, 2002). In these situations, there is a release of glucose through glycogenolysis (Laiz-Carrión et al, 2002;Soengas & Aldegunde, 2002), lipolysis (Shirdel, Kalbassi, Shokri, Olyaei, & Sharifpour, 2016) and the activation of gluconeogenesis (Laiz-Carrión et al, 2002;Shirdel et al, 2016) and fish use less exogenous glucose. Lactate levels also increase due to glucose reset lactate by gluconeogenesis (Tkachenko & Grudniewska, 2016).…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, ALT and AST are also recognized as biomarkers related to the TAS as, a general trend in its modulation and adaptation can be positively related to an improvement in the general antioxidant status, as observed in fish fed a diet supplemented with different doses of the antioxidant astaxantin (Wang et al, ). These are enzymes involved in carbohydrate and protein metabolism and their modulation/turnover in stress situations: if alanine and aspartate mobilization is required for glucose production by gluconeogenesis, their activities increase (Shirdel et al, ). In this study, only fish fed the diet supplemented with 3% DLP showed an increase in the activity of these enzymes at 15 and 30 days, whereas with the diet containing 1.5% DLP an increase, was observed, only, after 15 days.…”

Section: Discussionmentioning

confidence: 99%

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Effects of dietary dehydrated lemon peel on some biochemical markers related to general metabolism, welfare and stress in gilthead seabream (Sparus aurataL.)

et al. 2019

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Dehydrated lemon peel (DLP) at two levels (1.5% and 3%) was included for 30 days in the diet of gilthead seabream (Sparus aurata L.) and after 15 and 30 days the serum and skin mucus of fish were analysed. In serum, both experimental diets led to an initial decrease in glucose and lactate after which the levels became comparable to the control. Dietary DLP modulated the activity of transaminases, alanine aminotransferase and aspartate aminotransferase. The total antioxidant status showed a progressive increase in relation to levels of inclusion of DLP and time of administration (p < .05). In skin mucus, some biomolecular markers related to general stress, oxidative stress and apoptosis exhibited variations that suggest an adaptive response of fish to the new metabolic situation, resulting from the experimental diet. The inclusion of DLP in the diet seems to positively modulate the central metabolism and welfare of gilthead seabream.

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“…A decrease in the plasma protein content in common carp (Cyprinus carpio) exposed to pyrene in the highest concentration for 35 d [19].…”

Section: Discussionmentioning

confidence: 99%

Effect of Phenanthrene on the Tissue Structure of Liver and Aminotransferase Enzymes in Yellowfin Seabream (Acanthopagrus latus)

Shirmohammadi

Salamat

Ronagh

et al. 2017

IJT

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ABSTARCTBackground: Polycyclic aromatic hydrocarbons (PAHs) such as phenanthrene (Phe) represent one of the most abundant forms of organic pollutants. The aim of this study was to assess changes in plasma levels of aminotransferase enzymes, total protein and liver tissue as biomarkers of yellowfin seabream (Acanthopagrus latus) exposed to Phe for 14 d. Methods:The research was carried out in January 2016 at Khorramshahr University of Marine Sciences and Technology, Khorramshahr, Iran. Some 72 fish were injected with 2, 20, 40 and 70 mg/kg of Phe. Then tissue and blood samples were obtained at 1, 4, 7 and 14 d after injection. Results:Exposure of fish to Phe resulted in a significant increase of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and decrease of total protein after 7 d of the experiment (P<0.05). The main histopathological alteration was showed in different sampling days including nucleus margination, hypertrophy, vacuolation, melanomacrophages aggregates, sinusoid dilation, degeneration and picnotic nucleus. Degree of tissue change (DTC) of liver was recorded in the Phe-exposed fish from normal range to moderate changes. Conclusion:The studied biomarkers such as changes in concentrations of ALT, AST and total protein as well as tissue damages in liver may be served as beneficial biomarker to assess Phe toxicity in yellowfin seabream.

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The response of thyroid hormones, biochemical and enzymological biomarkers to pyrene exposure in common carp (Cyprinus carpio)

Cited by 27 publications

References 66 publications

Exposure and Recovery of the Gulf Toadfish (Opsanus beta) to Weathered Deepwater Horizon Slick Oil: Impacts on Liver and Blood Endpoints

Exposure and Recovery of the Gulf Toadfish (Opsanus beta) to Weathered Deepwater Horizon Slick Oil: Impacts on Liver and Blood Endpoints

Effects of dietary dehydrated lemon peel on some biochemical markers related to general metabolism, welfare and stress in gilthead seabream (Sparus aurataL.)

Effect of Phenanthrene on the Tissue Structure of Liver and Aminotransferase Enzymes in Yellowfin Seabream (Acanthopagrus latus)

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